PMID- 30210914
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 2156-6976 (Print)
IS  - 2156-6976 (Electronic)
IS  - 2156-6976 (Linking)
VI  - 8
IP  - 8
DP  - 2018
TI  - The lncKLF6/KLF6 feedback loop regulates the growth of non-small cell lung 
      cancer.
PG  - 1427-1439
AB  - Non-small lung cancer (NSCLC) is one of the most common causes of 
      cancer-associated death worldwide. Long noncoding RNAs (lncRNAs) regulate cancer 
      initiation and progression through different mechanisms. In the present study, we 
      characterized a novel lncRNA named lncKLF6, which was upregulated in NSCLC and 
      associated with poor clinical outcomes. lncKLF6 inhibited Kruppel-like factor 6 
      (KLF6) transcription and then facilitated NSCLC growth. lncKLF6 is associated 
      with the epigenetic repressor BMI1 and regulates its stability via recruiting 
      deubiquitinase USP22. Moreover, it was revealed that lncKLF6 was a 
      KLF6-responsive lncRNA, as KLF6 could occupy the lncKLF6 promoter to facilitate 
      its transcription. The negative feedback loop of lncKLF6 and KLF6 continuously 
      enhanced the oncogenic effects. Thus, our study elucidates the mechanism of 
      lncKLF6-mediated growth via suppression of KLF6, which provides the promising 
      target for developing new therapeutic strategy in NSCLC.
FAU - Li, Fei
AU  - Li F
AD  - Department of Pulmonary and Critical Care Medicine (PCCM) ward II, Hebei Cangzhou 
      Central Hospital Hebei Province, China.
FAU - Zhang, Qianyun
AU  - Zhang Q
AD  - Department of Pulmonary and Critical Care Medicine (PCCM) ward II, Hebei Cangzhou 
      Central Hospital Hebei Province, China.
FAU - Gong, Yange
AU  - Gong Y
AD  - Department of Pulmonary and Critical Care Medicine (PCCM) ward II, Hebei Cangzhou 
      Central Hospital Hebei Province, China.
FAU - Yu, Jinxiang
AU  - Yu J
AD  - Department of Pulmonary and Critical Care Medicine (PCCM) ward II, Hebei Cangzhou 
      Central Hospital Hebei Province, China.
LA  - eng
PT  - Journal Article
DEP - 20180801
PL  - United States
TA  - Am J Cancer Res
JT  - American journal of cancer research
JID - 101549944
PMC - PMC6129497
OTO - NOTNLM
OT  - KLF6
OT  - USP22
OT  - deubiquitin
OT  - feedback
OT  - growth
COIS- None.
EDAT- 2018/09/14 06:00
MHDA- 2018/09/14 06:01
PMCR- 2018/08/01
CRDT- 2018/09/14 06:00
PHST- 2018/07/15 00:00 [received]
PHST- 2018/07/30 00:00 [accepted]
PHST- 2018/09/14 06:00 [entrez]
PHST- 2018/09/14 06:00 [pubmed]
PHST- 2018/09/14 06:01 [medline]
PHST- 2018/08/01 00:00 [pmc-release]
PST - epublish
SO  - Am J Cancer Res. 2018 Aug 1;8(8):1427-1439. eCollection 2018.