PMID- 30211294
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220321
IS  - 2352-9067 (Print)
IS  - 2352-9067 (Electronic)
IS  - 2352-9067 (Linking)
VI  - 21
DP  - 2018 Dec
TI  - A study of association between platelet volume indices and ST elevation 
      myocardial infarction.
PG  - 7-10
LID - 10.1016/j.ijcha.2018.09.001 [doi]
AB  - INTRODUCTION AND OBJECTIVE: ST elevation myocardial infarction (STEMI) is caused 
      by formation of a thrombus at a ruptured atheromatous plaque. Larger platelets 
      are enzymatically and metabolically more active and play a crucial role in 
      thrombus formation. Our objective was to study the association between platelet 
      volume indices (mean platelet volume (MPV) and platelet distribution width (PDW)) 
      and STEMI. METHODS: A hospital-based case control study to compare the platelet 
      indices of 52 STEMI patients before commencing antiplatelet therapy and age and 
      gender matched 52 controls who had no history of ischemic heart disease or 
      antiplatelet therapy. Blood samples were collected to EDTA bottles and analyzed 
      using Mindray BC 6800 automated analyzer. RESULTS: STEMI patients had 
      significantly increased mean MPV and PDW compared to the control group 
      ((8.22 +/- 0.99 fL vs 7.74 +/- 0.69 fL, p = 0.005) and (15.81 +/- 0.41 fL vs 
      15.62 +/- 0.33 fL, p = 0.007) respectively). Significant positive correlation 
      existed between MPV and PDW (R = 0.556, p = 0.000) and weak negative correlation 
      in platelet count with MPV (R = -0.323, p = 0.019) and PDW (R = -0.309, 
      p = 0.026) of STEMI patients. Receiver Operating Characteristic (ROC) curves 
      showed that MPV and PDW with cutoff values of 7.55 fL, 15.55 fL and with Area 
      under the curve (AUC) of 0.640, 0.620 respectively. The sensitivities and 
      specificities were found to be 73.1%, 69.2% and 61.5%, 55.8% for MPV and PDW 
      respectively. CONCLUSION: Increased MPV and PDW were found to have a significant 
      association with STEMI and this test has the potential to be used as a 
      preliminary test to identify high-risk patient for myocardial infarction.
FAU - Alvitigala, Bhawani Yasassri
AU  - Alvitigala BY
AD  - Department of Medical Laboratory Sciences, Faculty of Allied Health Sciences, 
      General Sir John Kotelawala Defence University, Sri Lanka.
FAU - Azra, Mohammedu Aroos Fathima
AU  - Azra MAF
AD  - Department of Medical Laboratory Sciences, Faculty of Allied Health Sciences, 
      General Sir John Kotelawala Defence University, Sri Lanka.
FAU - Kottahachchi, Darshana Udakara
AU  - Kottahachchi DU
AD  - Department of Medical Laboratory Sciences, Faculty of Allied Health Sciences, 
      General Sir John Kotelawala Defence University, Sri Lanka.
FAU - Jayasekera, Madduma Mudiyanselage Priyamali Thusharika
AU  - Jayasekera MMPT
AD  - Department of Clinical Sciences, Faculty of Medicine, General Sir John Kotelawala 
      Defence University, Sri Lanka.
FAU - Wijesinghe, Rajapaksha Arachchige Namal Kumarasiri
AU  - Wijesinghe RANK
AD  - Department of Clinical Sciences, Faculty of Medicine, General Sir John Kotelawala 
      Defence University, Ratmalana, Sri Lanka.
LA  - eng
PT  - Journal Article
DEP - 20180911
PL  - Ireland
TA  - Int J Cardiol Heart Vasc
JT  - International journal of cardiology. Heart & vasculature
JID - 101649525
PMC - PMC6134176
OTO - NOTNLM
OT  - Coronary artery disease
OT  - Mean platelet volume
OT  - Platelet distribution width
EDAT- 2018/09/14 06:00
MHDA- 2018/09/14 06:01
PMCR- 2018/09/11
CRDT- 2018/09/14 06:00
PHST- 2018/08/08 00:00 [received]
PHST- 2018/09/01 00:00 [revised]
PHST- 2018/09/04 00:00 [accepted]
PHST- 2018/09/14 06:00 [entrez]
PHST- 2018/09/14 06:00 [pubmed]
PHST- 2018/09/14 06:01 [medline]
PHST- 2018/09/11 00:00 [pmc-release]
AID - S2352-9067(18)30103-9 [pii]
AID - 10.1016/j.ijcha.2018.09.001 [doi]
PST - epublish
SO  - Int J Cardiol Heart Vasc. 2018 Sep 11;21:7-10. doi: 10.1016/j.ijcha.2018.09.001. 
      eCollection 2018 Dec.