PMID- 30212819
OWN - NLM
STAT- MEDLINE
DCOM- 20190128
LR  - 20190128
IS  - 1663-2826 (Electronic)
IS  - 1663-2818 (Print)
IS  - 1663-2818 (Linking)
VI  - 90
IP  - 2
DP  - 2018
TI  - Prenatal Exposure to Persistent Organic Pollutants and Anogenital Distance in 
      Children at 18 Months.
PG  - 116-122
LID - 10.1159/000492236 [doi]
AB  - BACKGROUND: Anogenital distance (AGD) is a measure of in utero exposure to 
      hormonally active agents. The aim of the present study was to evaluate the 
      association between prenatal exposure to persistent organic pollutants (POPs) and 
      AGD. METHODS: POP levels were measured in pregnant women, and the AGD was 
      recorded in 43 offspring at 18 months. We used linear regression models to 
      analyze the association between maternal POP exposure and offspring AGD. We 
      defined the anogenital index (AGI) as AGD divided by weight at 18 months (AGI = 
      AGD / weight at 18 months [mm/kg]) and included this variable in the regression 
      models. RESULTS: AGI measure was 2.35 (0.61) and 1.38 (0.45) in males and 
      females, respectively. AGI was inversely associated with lipid-adjusted 
      concentrations of PBDE-99 (beta = -0.28, 95% confidence interval [CI]: -0.51, -0.04) 
      and PBDE-153 (beta = -0.61, 95% CI: -1.11, -0.11) in males. We did not find any 
      statistically significant relationship between any POPs and AGI in females. 
      CONCLUSIONS: Environmental exposure to POPs may affect genital development and 
      result in reproductive tract alterations with potentially relevant health 
      consequences in maturity.
CI  - The Author(s). Published by S. Karger AG, Basel.
FAU - Garcia-Villarino, Miguel
AU  - Garcia-Villarino M
AD  - Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), 
      Madrid, Spain.
AD  - Unit of Molecular Cancer Epidemiology, University Institute of Oncology of the 
      Principality of Asturias (IUOPA), Department of Medicine, University of Oviedo, 
      Oviedo, Spain.
FAU - Riano-Galan, Isolina
AU  - Riano-Galan I
AD  - Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), 
      Madrid, Spain.
AD  - Pediatric Endocrinology, HUCA, Oviedo, Spain.
FAU - Rodriguez-Dehli, Ana Cristina
AU  - Rodriguez-Dehli AC
AD  - Pediatric Endocrinology, San Agustin Hospital, Aviles, Spain.
FAU - Vizcaino, Esther
AU  - Vizcaino E
AD  - Department of Environmental Chemistry, Institute of Environmental Assessment and 
      Water Research (IDAEA-CSIC), Barcelona, Spain.
FAU - Grimalt, Joan O
AU  - Grimalt JO
AD  - Department of Environmental Chemistry, Institute of Environmental Assessment and 
      Water Research (IDAEA-CSIC), Barcelona, Spain.
FAU - Tardon, Adonina
AU  - Tardon A
AD  - Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), 
      Madrid, Spain.
AD  - Unit of Molecular Cancer Epidemiology, University Institute of Oncology of the 
      Principality of Asturias (IUOPA), Department of Medicine, University of Oviedo, 
      Oviedo, Spain.
FAU - Fernandez-Somoano, Ana
AU  - Fernandez-Somoano A
AD  - Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), 
      Madrid, Spain.
AD  - Unit of Molecular Cancer Epidemiology, University Institute of Oncology of the 
      Principality of Asturias (IUOPA), Department of Medicine, University of Oviedo, 
      Oviedo, Spain.
LA  - eng
PT  - Journal Article
DEP - 20180913
PL  - Switzerland
TA  - Horm Res Paediatr
JT  - Hormone research in paediatrics
JID - 101525157
RN  - 0 (Endocrine Disruptors)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Halogenated Diphenyl Ethers)
RN  - 0 (Organic Chemicals)
RN  - 7REL09ZX35 (pentabromodiphenyl ether)
RN  - CIW5S16655 (DDT)
SB  - IM
MH  - Anal Canal/drug effects/*pathology
MH  - *Body Weights and Measures
MH  - Cohort Studies
MH  - DDT/toxicity
MH  - Endocrine Disruptors/*toxicity
MH  - Environmental Pollutants/*toxicity
MH  - Female
MH  - Genitalia/drug effects/*pathology
MH  - Halogenated Diphenyl Ethers/toxicity
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Male
MH  - *Maternal Exposure/adverse effects
MH  - Organic Chemicals/*toxicity
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects/chemically induced/*pathology
PMC - PMC6214604
OTO - NOTNLM
OT  - Anogenital distance
OT  - Children
OT  - Endocrine disruption
OT  - Environmental contaminants
OT  - Persistent organic pollutants
EDAT- 2018/09/14 06:00
MHDA- 2019/01/29 06:00
PMCR- 2018/09/13
CRDT- 2018/09/14 06:00
PHST- 2018/02/19 00:00 [received]
PHST- 2018/07/18 00:00 [accepted]
PHST- 2018/09/14 06:00 [pubmed]
PHST- 2019/01/29 06:00 [medline]
PHST- 2018/09/14 06:00 [entrez]
PHST- 2018/09/13 00:00 [pmc-release]
AID - 000492236 [pii]
AID - hrp-0090-0116 [pii]
AID - 10.1159/000492236 [doi]
PST - ppublish
SO  - Horm Res Paediatr. 2018;90(2):116-122. doi: 10.1159/000492236. Epub 2018 Sep 13.