PMID- 30212938
OWN - NLM
STAT- MEDLINE
DCOM- 20180925
LR  - 20221005
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 97
IP  - 37
DP  - 2018 Sep
TI  - Effects of platelet-rich plasma in the treatment of plantar fasciitis: A 
      meta-analysis of randomized controlled trials.
PG  - e12110
LID - 10.1097/MD.0000000000012110 [doi]
LID - e12110
AB  - BACKGROUND: Plantar fasciitis is a common cause of heel pain, which often results 
      in significant morbidity. There have been several treatment options that are used 
      for plantar fasciitis, including nonsteroidal anti-inflammatory drugs, orthoses, 
      physical therapy, and steroid injections. OBJECTIVES: The aim of this 
      meta-analysis was to compare the effects of platelet-rich plasma (PRP) and other 
      treatments in patients with plantar fasciitis. SEARCH METHODS: Medline, Web of 
      Science, and Embase were systematically searched to identify relevant trials. 
      SELECTION CRITERIA: Randomized controlled trials (RCTs) that compared the effects 
      of PRP and other treatments on plantar fasciitis were included. DATA COLLECTION 
      AND ANALYSIS: The main outcomes included changes from baseline in visual analog 
      scale (VAS) score, American Orthopaedic Foot and Ankle Society Score (AOFAS), and 
      Roles-Maudsley score (RMS). Results were expressed as weight mean difference 
      (WMD) with 95% confidence interval (95% CI). The meta-analysis was performed 
      using a fixed-effects or random-effects model according to heterogeneity. MAIN 
      RESULTS: Ten RCTs involving a total of 445 patients with plantar fasciitis were 
      included. Among these studies, 9 compared PRP with steroid, and 1 compared PRP 
      with whole blood.Four studies were categorized as being at low risk of bias, and 
      the remaining 6 as being at unclear risk of bias.Pooled estimates suggested that 
      PRP had greater changes in VAS and AOFAS scores than other treatments. However, 
      it had no benefit effect in the RMS.Subgroup analysis for VAS and AOFAS showed 
      that PRP had superior effect than other treatments at 12 months, but not at the 
      1, 3, 6 months.Subgroup analysis based on treatment regimens demonstrated that 
      PRP was more effective than steroid in the change from baseline in AOFAS, but not 
      in VAS and RMS scores. AUTHORS' CONCLUSION: PRP was as effective as other 
      treatments in reducing pain and improving function in patients with plantar 
      fasciitis. Subgroup analysis indicated that PRP had better effect than steroid in 
      AOFAS Score and its effect was durable in a long term. However, considering the 
      potential limitations in this study, more large-scale RCTs are needed to confirm 
      the current findings.
FAU - Ling, Yan
AU  - Ling Y
AD  - Department of Rehabilitation, Research Center of Sports Rehabilitation of 
      Shandong Department of Rehabilitation, Shandong Sports Hospital, Jinan, China.
FAU - Wang, Shu
AU  - Wang S
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Adrenal Cortex Hormones)
SB  - IM
MH  - Adrenal Cortex Hormones/therapeutic use
MH  - Fasciitis, Plantar/*therapy
MH  - Humans
MH  - Pain Measurement
MH  - *Platelet-Rich Plasma
MH  - Randomized Controlled Trials as Topic
PMC - PMC6156022
COIS- The authors have no conflicts of interest to disclose.
EDAT- 2018/09/15 06:00
MHDA- 2018/09/27 06:00
PMCR- 2018/09/14
CRDT- 2018/09/15 06:00
PHST- 2018/09/15 06:00 [entrez]
PHST- 2018/09/15 06:00 [pubmed]
PHST- 2018/09/27 06:00 [medline]
PHST- 2018/09/14 00:00 [pmc-release]
AID - 00005792-201809140-00015 [pii]
AID - MD-D-18-02036 [pii]
AID - 10.1097/MD.0000000000012110 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2018 Sep;97(37):e12110. doi: 10.1097/MD.0000000000012110.