PMID- 30212992
OWN - NLM
STAT- MEDLINE
DCOM- 20180920
LR  - 20221005
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 97
IP  - 37
DP  - 2018 Sep
TI  - Risk factors associated with nonalcohol fatty liver disease and fibrosis among 
      patients with type 2 diabetes mellitus.
PG  - e12356
LID - 10.1097/MD.0000000000012356 [doi]
LID - e12356
AB  - Type 2 diabetes mellitus (T2DM) is closely related to hepatic steatosis and 
      fibrosis. The aim of this study was to analyze the occurrence of hepatic 
      steatosis and fibrosis in patients with T2DM and to explore the risk factors.A 
      total of 629 patients with T2DM were enrolled. Liver stiffness value (LSV) and 
      controlled attenuation parameters (CAP) were measured using Fibroscan. Liver 
      fibrosis was diagnosed when LSV was greater than 7.4 kPa, and advanced liver 
      fibrosis was diagnosed when LSV was greater than 10.6 kPa. Hepatic steatosis 
      diagnosis was made when CAP value was greater than 238 dB/m. Demographic 
      information, physical examination data, and laboratory tests results were 
      collected. The 629 patients were classified into 2 groups by the liver fibrosis 
      and liver steatosis, and then the difference was analyzed.Among patients 
      enrolled, 231 patients were diagnosed as liver fibrosis. The age of the patients 
      in the fibrosis group was significantly greater than that in the non-fibrosis 
      group, and similar trends were observed in the waist-hip ratio (WHR), systolic 
      blood pressure, and diastolic blood pressure. The proportion of smoking and 
      alcoholic consumption was significantly lower in patients with non-fibrosis 
      group. A total of 426 patients were diagnosed with liver steatosis. Body mass 
      index (BMI), WHR, systolic blood pressure, and diastolic blood pressure in 
      patients with steatosis were significantly higher than those in non-steatosis 
      group. We observed that the LSV (P = .042) and CAP value (P < .001) are 
      positively correlated with metabolic syndrome components in T2DM patients. Older 
      age (OR = 1.099, P = .001), high BMI (OR = 1.088, P = .003), low platelet level 
      (OR = 0.996, P = .014), and smoking (OR = 1.653, P = .013) were independent risk 
      factors of liver fibrosis among T2DM patients. High BMI (OR = 1.369, P < .001), 
      high diastolic blood pressure (OR = 1.048, P < .001), and high gamma glutamyl 
      transpeptidase (OR = 1.018, P = .009) were independent risk factors for liver 
      steatosis among T2DM patients.This study suggested risk factors screening of 
      liver fibrosis and steatosis. Timely intervention should be taken into 
      consideration among high risk patients to prevent progress liver diseases.
FAU - Zhao, Hongli
AU  - Zhao H
AD  - Department of Endocrinology, People's Hospital of Xinjiang Uygur Autonomous 
      Region, Urumqi Department of Medicine, Xinjiang Altay Region People's Hospital, 
      Altay, Xinjiang, P.R. China.
FAU - Song, Xiangxin
AU  - Song X
FAU - Li, Zhang
AU  - Li Z
FAU - Wang, Xinling
AU  - Wang X
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
SB  - IM
MH  - Adult
MH  - Alcohol Drinking/adverse effects
MH  - Blood Pressure
MH  - Body Mass Index
MH  - Diabetes Mellitus, Type 2/*complications/physiopathology
MH  - Elasticity Imaging Techniques/methods
MH  - Female
MH  - Humans
MH  - Liver/diagnostic imaging
MH  - Liver Cirrhosis/*etiology
MH  - Male
MH  - Middle Aged
MH  - Non-alcoholic Fatty Liver Disease/*etiology
MH  - Risk Factors
PMC - PMC6156034
COIS- The authors have no funding and conflicts of interest to disclose.
EDAT- 2018/09/15 06:00
MHDA- 2018/09/21 06:00
PMCR- 2018/09/14
CRDT- 2018/09/15 06:00
PHST- 2018/09/15 06:00 [entrez]
PHST- 2018/09/15 06:00 [pubmed]
PHST- 2018/09/21 06:00 [medline]
PHST- 2018/09/14 00:00 [pmc-release]
AID - 00005792-201809140-00069 [pii]
AID - MD-D-18-03573 [pii]
AID - 10.1097/MD.0000000000012356 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2018 Sep;97(37):e12356. doi: 10.1097/MD.0000000000012356.