PMID- 30213062
OWN - NLM
STAT- MEDLINE
DCOM- 20181217
LR  - 20191210
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 10
IP  - 9
DP  - 2018 Sep 12
TI  - Wholegrain Intake and Risk of Type 2 Diabetes: Evidence from Epidemiological and 
      Intervention Studies.
LID - 10.3390/nu10091288 [doi]
LID - 1288
AB  - Type 2 diabetes mellitus (T2DM) is one of the most common metabolic diseases and 
      represents a leading cause of morbidity and mortality because of its related 
      complications. The alarming rise in T2DM prevalence worldwide poses enormous 
      challenges in relation to its social, economic, and a clinical burden requiring 
      appropriate preventive strategies. Currently, lifestyle modifications-including 
      approaches to promote a moderate body weight reduction and to increase regular 
      physical exercise-are the first crucial intervention for T2DM prevention. In the 
      light of the difficulty in reducing body weight and in long-term maintenance of 
      weight loss, quality changes in dietary patterns-in terms of macro and 
      micronutrient composition-can also strongly affect the development of T2DM. This 
      may provide a more practical and suitable preventative approach than simply 
      implementing caloric restriction. Along this line, there is increasing evidence 
      that wholegrain consumption in substitution of refined grains is associated with 
      a reduction of the incidence of several non-communicable chronic diseases. The 
      aim of the present review is to summarize the current evidence from observational 
      and randomized controlled clinical trials on the benefits of wholegrain on T2DM 
      prevention and treatment. Plausible mechanisms by which wholegrain could act on 
      glucose homeostasis and T2DM prevention are also evaluated. Altogether, the 
      totality of the available evidence supports present dietary recommendations 
      promoting wholegrain foods for the prevention and treatment of T2DM.
FAU - Della Pepa, Giuseppe
AU  - Della Pepa G
AD  - Department of Clinical Medicine and Surgery, "Federico II" University, 80131 
      Naples, Italy. giuseppe.dellapepa@unina.it.
FAU - Vetrani, Claudia
AU  - Vetrani C
AD  - Department of Clinical Medicine and Surgery, "Federico II" University, 80131 
      Naples, Italy. c.vetrani@libero.it.
FAU - Vitale, Marilena
AU  - Vitale M
AUID- ORCID: 0000-0002-3566-4363
AD  - Department of Clinical Medicine and Surgery, "Federico II" University, 80131 
      Naples, Italy. marilena.vitale@yahoo.it.
FAU - Riccardi, Gabriele
AU  - Riccardi G
AD  - Department of Clinical Medicine and Surgery, "Federico II" University, 80131 
      Naples, Italy. gabriele.riccardi@unina.it.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20180912
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
RN  - 0 (Biomarkers)
RN  - 0 (Blood Glucose)
SB  - IM
MH  - Biomarkers/blood
MH  - Blood Glucose/metabolism
MH  - Diabetes Mellitus, Type 2/blood/diagnosis/epidemiology/*prevention & control
MH  - *Diet, Healthy
MH  - Humans
MH  - Incidence
MH  - *Nutritive Value
MH  - Protective Factors
MH  - *Recommended Dietary Allowances
MH  - Risk Assessment
MH  - Risk Factors
MH  - *Risk Reduction Behavior
MH  - *Whole Grains
PMC - PMC6163785
OTO - NOTNLM
OT  - diabetes diet
OT  - diabetes prevention
OT  - plasma glucose
OT  - plasma insulin
OT  - type 2 diabetes mellitus
OT  - wholegrain
COIS- Some of the trials on wholegrain performed by the authors that were reviewed in 
      this paper have been funded, in part, by Barilla.
EDAT- 2018/09/15 06:00
MHDA- 2018/12/18 06:00
PMCR- 2018/09/01
CRDT- 2018/09/15 06:00
PHST- 2018/08/03 00:00 [received]
PHST- 2018/09/03 00:00 [revised]
PHST- 2018/09/10 00:00 [accepted]
PHST- 2018/09/15 06:00 [entrez]
PHST- 2018/09/15 06:00 [pubmed]
PHST- 2018/12/18 06:00 [medline]
PHST- 2018/09/01 00:00 [pmc-release]
AID - nu10091288 [pii]
AID - nutrients-10-01288 [pii]
AID - 10.3390/nu10091288 [doi]
PST - epublish
SO  - Nutrients. 2018 Sep 12;10(9):1288. doi: 10.3390/nu10091288.