PMID- 3021316
OWN - NLM
STAT- MEDLINE
DCOM- 19861218
LR  - 20190619
IS  - 0008-543X (Print)
IS  - 0008-543X (Linking)
VI  - 58
IP  - 11
DP  - 1986 Dec 1
TI  - Abnormal muscle fructose bisphosphatase activity in malnourished cancer patients.
PG  - 2448-52
AB  - Malnourished patients without cancer have abnormal glucose metabolism, low 
      activities of the key enzymes of glycolysis in muscle, and abnormal muscle 
      fiber-type distribution. Malnutrition in cancer is also associated with altered 
      glucose metabolism, and therefore muscle enzyme activities and fiber types were 
      measured in 17 malnourished patients with gastrointestinal cancer (weight loss, 
      18.1% +/- 7.9 SD). These patients were matched with 17 depleted noncancer 
      patients (weight loss, 22.8% +/- 10.25 SD) and 17 normal controls. Results of in 
      vitro measurement of the maximal activity of phosphofructokinase (PFK), 
      hexokinase (HK), and oxogluterate dehydrogenase (OGD) were similar in both 
      undernourished groups and lower than that of normal controls. Both groups also 
      had reduced Type II fiber size and number. The activity of fructose 
      bisphosphatase (FBP) was significantly higher in cancer patients (0.62 mu ml 
      min-1 g +/- 0.26 SD) than in noncancer patients (0.39 +/- 0.15), but similar to 
      that in controls (0.65 +/- 0.29). As FBP is involved in substrate cycling, 
      inappropriately high activity reflects an inability to adapt to malnutrition that 
      could lead to high rates of cycling and wasteful energy expenditure at times of 
      maximal activation of the cycle.
FAU - Church, J M
AU  - Church JM
FAU - Choong, B Y
AU  - Choong BY
FAU - Hill, G L
AU  - Hill GL
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer
JT  - Cancer
JID - 0374236
RN  - EC 1.2.4.2 (Ketoglutarate Dehydrogenase Complex)
RN  - EC 2.7.1.1 (Hexokinase)
RN  - EC 2.7.1.105 (Phosphofructokinase-2)
RN  - EC 2.7.1.11 (Phosphofructokinase-1)
RN  - EC 3.1.3.2 (Phosphoric Monoester Hydrolases)
SB  - IM
MH  - Aged
MH  - Calorimetry, Indirect
MH  - Female
MH  - Glycolysis
MH  - Hexokinase/metabolism
MH  - Histocytochemistry
MH  - Humans
MH  - Ketoglutarate Dehydrogenase Complex/metabolism
MH  - Male
MH  - Middle Aged
MH  - Muscles/*enzymology/pathology
MH  - Neoplasms/*enzymology/pathology
MH  - Nutrition Disorders/*enzymology/pathology
MH  - Phosphofructokinase-1/metabolism
MH  - Phosphofructokinase-2
MH  - Phosphoric Monoester Hydrolases/*metabolism
EDAT- 1986/12/01 00:00
MHDA- 1986/12/01 00:01
CRDT- 1986/12/01 00:00
PHST- 1986/12/01 00:00 [pubmed]
PHST- 1986/12/01 00:01 [medline]
PHST- 1986/12/01 00:00 [entrez]
AID - 10.1002/1097-0142(19861201)58:11<2448::aid-cncr2820581116>3.0.co;2-7 [doi]
PST - ppublish
SO  - Cancer. 1986 Dec 1;58(11):2448-52. doi: 
      10.1002/1097-0142(19861201)58:11<2448::aid-cncr2820581116>3.0.co;2-7.