PMID- 3021319
OWN - NLM
STAT- MEDLINE
DCOM- 19861218
LR  - 20190619
IS  - 0008-543X (Print)
IS  - 0008-543X (Linking)
VI  - 58
IP  - 11
DP  - 1986 Dec 1
TI  - Clinicopathologic features and prognosis for Wilms' tumor patients with 
      metastases at diagnosis.
PG  - 2501-11
AB  - Comparisons were made between 236 Wilms' tumor patients with metastasis to the 
      lungs and/or liver at initial diagnosis who were registered on the National 
      Wilms' Tumor Study (NWTS) during 1969 to 1983, and 1755 patients who did not have 
      overt metastases at diagnosis. Patients with evidence of regional spread of 
      disease beyond the kidney, especially if to the renal vein or lymph nodes, were 
      much more likely to have overt metastases present at diagnosis than those with 
      apparently localized disease. The presence of metastases was also correlated with 
      age at diagnosis, ranging from 1% among infants younger than 1 year of age to 24% 
      for those aged 6 years or older. The percentage of tumor deaths for patients with 
      metastases at diagnosis (Stage IV) and a primary tumor of favorable histology 
      (FH) declined from 29% at 2 years postdiagnosis on the first therapeutic trial 
      (NWTS-1) to 9% for the most recent one (NWTS-3), and is now comparable to that 
      for patients without metastases but with nonresectable local invasion at 
      diagnosis (Stage III). The local extent of disease also influenced the survival 
      outcome for Stage IV/FH patients. Survival was poor for those with anaplastic or 
      sarcomatous (unfavorable) histology, regardless of local staging or trial. There 
      was no difference in survival according to metastatic site (liver +/- lung vs. 
      lung only) if present prior to treatment. By contrast, patients who developed 
      liver metastases during or after treatment had an especially poor chance for 
      survival as compared with those who developed lung deposits at those times.
FAU - Breslow, N E
AU  - Breslow NE
FAU - Churchill, G
AU  - Churchill G
FAU - Nesmith, B
AU  - Nesmith B
FAU - Thomas, P R
AU  - Thomas PR
FAU - Beckwith, J B
AU  - Beckwith JB
FAU - Othersen, H B
AU  - Othersen HB
FAU - D'Angio, G J
AU  - D'Angio GJ
LA  - eng
GR  - CA-11722/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Cancer
JT  - Cancer
JID - 0374236
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Humans
MH  - Liver Neoplasms/*secondary
MH  - Lung Neoplasms/*secondary
MH  - Male
MH  - Neoplasm Staging
MH  - Nephrectomy
MH  - Prognosis
MH  - Random Allocation
MH  - Registries
MH  - Statistics as Topic
MH  - United States
MH  - Wilms Tumor/mortality/*pathology/therapy
EDAT- 1986/12/01 00:00
MHDA- 1986/12/01 00:01
CRDT- 1986/12/01 00:00
PHST- 1986/12/01 00:00 [pubmed]
PHST- 1986/12/01 00:01 [medline]
PHST- 1986/12/01 00:00 [entrez]
AID - 10.1002/1097-0142(19861201)58:11<2501::aid-cncr2820581125>3.0.co;2-v [doi]
PST - ppublish
SO  - Cancer. 1986 Dec 1;58(11):2501-11. doi: 
      10.1002/1097-0142(19861201)58:11<2501::aid-cncr2820581125>3.0.co;2-v.