PMID- 30213197
OWN - NLM
STAT- MEDLINE
DCOM- 20200910
LR  - 20200910
IS  - 1940-4034 (Electronic)
IS  - 1074-2484 (Linking)
VI  - 24
IP  - 2
DP  - 2019 Mar
TI  - Comparison of Efficacy between Ramipril and Carvedilol on Limiting the Expansion 
      of Abdominal Aortic Aneurysm in Mouse Model.
PG  - 172-181
LID - 10.1177/1074248418798631 [doi]
AB  - OBJECTIVE: Abdominal aortic aneurysm (AAA) is a common condition that may be 
      life-threatening when it is unrecognized. The aim of this study is to evaluate 
      and compare the efficacy of ramipril and carvedilol on limiting AAA expansion in 
      mouse model. METHODS AND RESULTS: A total of 36 experimental AAA mouse model was 
      induced with the continuous infusion of angiotensin II (Ang II) in 20-week-old 
      male apolipoprotein E-deficient mice. They were randomly divided into 3 treatment 
      groups and fed orally for 8 weeks; saline alone, ramipril (2.5 mg/30g/d), or 
      carvedilol (3.125 mg/30g/d), respectively. Aortic diameter (AD) was measured by 
      micro-computed tomography, and the level of biomarkers of aortic tissue such as 
      monocyte chemoattractant protein-1 (MCP-1) and tissue inhibitor matrix 
      metalloproteinase-1 (TIMP-1) was evaluated. After treatment, AD of both ramipril 
      and carvedilol group was smaller than in the saline group. The percentage change 
      of AD in both ramipril and carvedilol groups was significantly smaller than that 
      of the saline group. Pathologic examination revealed relatively well-preserved 
      aortic walls in the ramipril group compared to the carvedilol and saline groups. 
      The level of MCP-1 was markedly decreased in both the ramipril and carvedilol 
      groups compared to the saline group. The level of TIMP-1 was higher in the 
      carvedilol group when compared to either the saline or ramipril groups. 
      CONCLUSIONS: Ramipril and carvedilol treatment shows similar efficacy in limiting 
      AAA expansion in mouse model. Future clinical research would be warranted to 
      validate these results.
FAU - Park, Sang Min
AU  - Park SM
AUID- ORCID: 0000-0001-6521-303X
AD  - Division of Cardiology, Cardiovascular Center, Hallym University, Chuncheon, 
      South Korea.
AD  - Department of Medicine, The Graduate School of Yonsei University, Seoul, South 
      Korea.
FAU - Hong, Myeong-Ki
AU  - Hong MK
AD  - Department of Medicine, The Graduate School of Yonsei University, Seoul, South 
      Korea.
AD  - Division of Cardiology, Yonsei Cardiovascular Center, Yonsei University, Seoul, 
      South Korea.
FAU - Kim, Se Hoon
AU  - Kim SH
AD  - Department of Pathology, Yonsei University, Seoul, South Korea.
FAU - Jung, Subin
AU  - Jung S
AD  - Severance Integrative Research Institute for Cerebral & Cardiovascular Diseases, 
      Yonsei University Health System, Seoul, South Korea.
FAU - Kim, Bo Kyoung
AU  - Kim BK
AD  - Severance Integrative Research Institute for Cerebral & Cardiovascular Diseases, 
      Yonsei University Health System, Seoul, South Korea.
FAU - Choi, Donghoon
AU  - Choi D
AD  - Division of Cardiology, Yonsei Cardiovascular Center, Yonsei University, Seoul, 
      South Korea.
AD  - Severance Integrative Research Institute for Cerebral & Cardiovascular Diseases, 
      Yonsei University Health System, Seoul, South Korea.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180913
PL  - United States
TA  - J Cardiovasc Pharmacol Ther
JT  - Journal of cardiovascular pharmacology and therapeutics
JID - 9602617
RN  - 0 (Adrenergic beta-Antagonists)
RN  - 0 (Angiotensin-Converting Enzyme Inhibitors)
RN  - 0K47UL67F2 (Carvedilol)
RN  - L35JN3I7SJ (Ramipril)
SB  - IM
MH  - Adrenergic beta-Antagonists/*therapeutic use
MH  - Angiotensin-Converting Enzyme Inhibitors/*therapeutic use
MH  - Animals
MH  - Aortic Aneurysm, Abdominal/*drug therapy/*physiopathology
MH  - Carvedilol/*therapeutic use
MH  - Disease Models, Animal
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Ramipril/*therapeutic use
MH  - Random Allocation
OTO - NOTNLM
OT  - abdominal aortic aneurysm
OT  - carvedilol
OT  - mouse model
OT  - ramipril
EDAT- 2018/09/15 06:00
MHDA- 2020/09/12 06:00
CRDT- 2018/09/15 06:00
PHST- 2018/09/15 06:00 [pubmed]
PHST- 2020/09/12 06:00 [medline]
PHST- 2018/09/15 06:00 [entrez]
AID - 10.1177/1074248418798631 [doi]
PST - ppublish
SO  - J Cardiovasc Pharmacol Ther. 2019 Mar;24(2):172-181. doi: 
      10.1177/1074248418798631. Epub 2018 Sep 13.