PMID- 30214565
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 1792-1074 (Print)
IS  - 1792-1082 (Electronic)
IS  - 1792-1074 (Linking)
VI  - 16
IP  - 4
DP  - 2018 Oct
TI  - Changes in blood glucose of elderly patients with gastric cancer combined with 
      type 2 diabetes mellitus after radical operation and the effect of mediation 
      adjustment for blood glucose on the recovery of gastric cancer.
PG  - 4303-4308
LID - 10.3892/ol.2018.9197 [doi]
AB  - This study aimed to investigate the changes in blood glucose of elderly patients 
      with gastric cancer combined with type 2 diabetes mellitus (T2DM) after radical 
      operation. Forty-six patients in DM group and 30 patients in non-DM group 
      underwent radical surgery between January, 2007 and January, 2017 in The First 
      Hospital of Lanzhou University, and the clinical data were retrospectively 
      analyzed. Statistical analysis was conducted to explore the effect of radical 
      operation on blood glucose control of the two groups of patients. In 46 patients 
      with gastric cancer combined with T2DM, 24 patients received postoperative 
      insulin intervention, and the remaining 22 patients did not receive insulin 
      intervention. This latter set of patients comprised the non-insulin treatment 
      group. Blood glucose control conditions, inflammatory markers, tumor markers and 
      their effects on the prognosis were compared between the two groups. Level of 
      postoperative blood glucose of the DM group was significantly higher than that of 
      the non-DM group (P<0.05), while the level of blood glucose in the insulin 
      treatment group was significantly lower than that in the control group (P<0.05). 
      Levels of related tumor markers and inflammatory factors of insulin treatment 
      group were significantly higher than those of the control group (P<0.05). The 
      5-year survival rate of insulin treatment group was significantly higher than 
      that of the control group (P<0.05). Our results showed that the level of blood 
      glucose was significantly increased in elderly patients with gastric cancer 
      combined with T2DM after radical operation, and levels of blood glucose, tumor 
      markers and inflammatory factors in elderly gastric cancer patients with T2DM 
      without insulin were significantly increased after radical operation, and 
      long-term prognosis is poor.
FAU - Zhou, Yun
AU  - Zhou Y
AD  - Department of Gerontology, The First Hospital of Lanzhou University, Lanzhou, 
      Gansu 730000, P.R. China.
FAU - Liu, Shixiong
AU  - Liu S
AD  - Department of Gerontology, The First Hospital of Lanzhou University, Lanzhou, 
      Gansu 730000, P.R. China.
FAU - Wang, Jing
AU  - Wang J
AD  - Department of Gerontology, The First Hospital of Lanzhou University, Lanzhou, 
      Gansu 730000, P.R. China.
FAU - Yan, Xiang
AU  - Yan X
AD  - Department of Gerontology, The First Hospital of Lanzhou University, Lanzhou, 
      Gansu 730000, P.R. China.
FAU - Zhang, Lei
AU  - Zhang L
AD  - Department of General Surgery, The First Hospital of Lanzhou University, Lanzhou, 
      Gansu 730000, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20180723
PL  - Greece
TA  - Oncol Lett
JT  - Oncology letters
JID - 101531236
PMC - PMC6126197
OTO - NOTNLM
OT  - gastric cancer
OT  - postoperative blood glucose
OT  - prognosis
OT  - type 2 diabetes mellitus
EDAT- 2018/09/15 06:00
MHDA- 2018/09/15 06:01
PMCR- 2018/07/23
CRDT- 2018/09/15 06:00
PHST- 2017/09/26 00:00 [received]
PHST- 2018/06/28 00:00 [accepted]
PHST- 2018/09/15 06:00 [entrez]
PHST- 2018/09/15 06:00 [pubmed]
PHST- 2018/09/15 06:01 [medline]
PHST- 2018/07/23 00:00 [pmc-release]
AID - OL-0-0-9197 [pii]
AID - 10.3892/ol.2018.9197 [doi]
PST - ppublish
SO  - Oncol Lett. 2018 Oct;16(4):4303-4308. doi: 10.3892/ol.2018.9197. Epub 2018 Jul 
      23.