PMID- 30214652
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230928
IS  - 1918-3003 (Print)
IS  - 1918-3011 (Electronic)
IS  - 1918-3003 (Linking)
VI  - 10
IP  - 10
DP  - 2018 Oct
TI  - Dabigatran-Induced Acute Interstitial Nephritis: An Important Complication of 
      Newer Oral Anticoagulation Agents.
PG  - 791-794
LID - 10.14740/jocmr3569w [doi]
AB  - Acute kidney injury (AKI) due to an acute interstitial nephritis (AIN) is common 
      and can lead to increased morbidity and mortality. Medications such as 
      antibiotics, nonsteroidal anti-inflammatory drugs (NSAIDs), proton pump 
      inhibitors (PPI) and rifampin are common offending agents. 
      Anticoagulant-associated AIN is more frequently reported with the use of 
      warfarin; however, only few case reports have reported an association with the 
      use of novel oral anticoagulants (NOACs). Herein, we report the case of a 
      59-year-old male who developed AKI after initiating dabigatran for the treatment 
      of atrial fibrillation. Laboratory data demonstrated elevated blood urea nitrogen 
      (BUN) of 115 mg/dL (baseline = 35 mg/dL) and serum creatinine (Cr) of 5.06 mg/dL 
      (baseline = 1.3 mg/dL). Urinalysis revealed eosinophiluria. Renal biopsy 
      disclosed diffuse tubulointerstitial nephritis and eosinophils and confirmed the 
      diagnosis of AIN. At 1 week, renal function improved (BUN/Cr = 53/2.73 mg/dL) 
      with steroid therapy and discontinuation of dabigatran. With an increasing use of 
      NOACs, it is important to monitor renal function to diagnose AIN in a timely 
      fashion. Early diagnosis and prompt treatment can mitigate serious renal damage 
      induced by dabigatran.
FAU - Patel, Swapnil
AU  - Patel S
AD  - Department of Medicine, Jersey Shore University Medical Center, Hackensack 
      Meridian Health, Neptune, NJ 07753, USA.
FAU - Hossain, Mohammad A
AU  - Hossain MA
AD  - Department of Medicine, Jersey Shore University Medical Center, Hackensack 
      Meridian Health, Neptune, NJ 07753, USA.
FAU - Ajam, Firas
AU  - Ajam F
AD  - Department of Medicine, Jersey Shore University Medical Center, Hackensack 
      Meridian Health, Neptune, NJ 07753, USA.
FAU - Patel, Mayurkumar
AU  - Patel M
AD  - Department of Medicine, Jersey Shore University Medical Center, Hackensack 
      Meridian Health, Neptune, NJ 07753, USA.
FAU - Nakrani, Mihir
AU  - Nakrani M
AD  - Department of Medicine, Jersey Shore University Medical Center, Hackensack 
      Meridian Health, Neptune, NJ 07753, USA.
FAU - Patel, Jasmine
AU  - Patel J
AD  - Department of Medicine, Jersey Shore University Medical Center, Hackensack 
      Meridian Health, Neptune, NJ 07753, USA.
FAU - Alhillan, Alsadiq
AU  - Alhillan A
AD  - Department of Medicine, Jersey Shore University Medical Center, Hackensack 
      Meridian Health, Neptune, NJ 07753, USA.
FAU - Hammoda, Mohamed
AU  - Hammoda M
AD  - Department of Medicine, Jersey Shore University Medical Center, Hackensack 
      Meridian Health, Neptune, NJ 07753, USA.
FAU - Alrefaee, Anas
AU  - Alrefaee A
AD  - Department of Medicine, Jersey Shore University Medical Center, Hackensack 
      Meridian Health, Neptune, NJ 07753, USA.
FAU - Levitt, Michael
AU  - Levitt M
AD  - Department of Medicine, Jersey Shore University Medical Center, Hackensack 
      Meridian Health, Neptune, NJ 07753, USA.
FAU - Asif, Arif
AU  - Asif A
AD  - Department of Medicine, Jersey Shore University Medical Center, Hackensack 
      Meridian Health, Neptune, NJ 07753, USA.
LA  - eng
PT  - Case Reports
DEP - 20180910
PL  - Canada
TA  - J Clin Med Res
JT  - Journal of clinical medicine research
JID - 101538301
PMC - PMC6134997
OTO - NOTNLM
OT  - Acute interstitial nephritis
OT  - Acute kidney injury
OT  - Anticoagulation
OT  - Dabigatran
OT  - NOAC
COIS- The authors have no conflict of interest to declare.
EDAT- 2018/09/15 06:00
MHDA- 2018/09/15 06:01
PMCR- 2018/09/10
CRDT- 2018/09/15 06:00
PHST- 2018/08/07 00:00 [received]
PHST- 2018/08/21 00:00 [accepted]
PHST- 2018/09/15 06:00 [entrez]
PHST- 2018/09/15 06:00 [pubmed]
PHST- 2018/09/15 06:01 [medline]
PHST- 2018/09/10 00:00 [pmc-release]
AID - 10.14740/jocmr3569w [doi]
PST - ppublish
SO  - J Clin Med Res. 2018 Oct;10(10):791-794. doi: 10.14740/jocmr3569w. Epub 2018 Sep 
      10.