PMID- 30214967
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220321
IS  - 2467-981X (Electronic)
IS  - 2467-981X (Linking)
VI  - 2
DP  - 2017
TI  - Repeatability of long intracortical inhibition in healthy subjects.
PG  - 26-34
LID - 10.1016/j.cnp.2016.12.004 [doi]
AB  - OBJECTIVES: Transcranial magnetic stimulation (TMS) is widely used to assess 
      cortical excitability. To detect changes in excitability with longitudinal 
      studies, it is important to validate the repeatability of excitability measures 
      within a subject between different sessions. Repeatability studies on long 
      intracortical inhibition (LICI) are limited and reported agreement ranges from 
      poor to good. This study aims to evaluate the repeatability of LICI in healthy 
      subjects using paired pulse TMS. In addition, it investigates whether LICI 
      repeatability differs for manual and robot-guided coil positioning. METHODS: 
      Thirty healthy subjects (10 males, mean age 28.4 +/- 8.2 years) were studied twice, 
      approximately one week apart. Both motor cortices were stimulated with 50 paired 
      pulses (intensity 120% of resting motor threshold) at interstimulus intervals 
      (ISIs): 50, 100, 150, 200, 250 and 300 ms. In twenty subjects a figure-of-eight 
      coil was positioned and held in place manually during both sessions, while in ten 
      subjects a robot-navigated arm was used. LICI repeatability was assessed using 
      the intraclass correlation coefficient (ICC). RESULTS: For manual and 
      robot-guided coil positioning we found a large variation in repeatability at the 
      subject level and ISI level, ranging from poor to good agreement. On a group 
      level, we found good repeatability for averaged LICI curves (manual: ICC = 0.91, 
      robot-guided: ICC = 0.95), which decreased when individual curves were correlated 
      between sessions (manual: ICC = 0.76, robot-guided: ICC = 0.84). CONCLUSION: For 
      a correct interpretation of longitudinal study outcomes it is important to know 
      the subject specific LICI repeatability and to analyze each ISI individually. 
      Furthermore, the added value of robot-guided coil positioning for paired pulse 
      TMS seems limited. SIGNIFICANCE: The large variation in LICI repeatability at the 
      subject level and ISI level should be taken into account in longitudinal studies, 
      while robot-guided coil positioning seems unnecessary.
FAU - de Goede, Annika A
AU  - de Goede AA
AD  - Department of Clinical Neurophysiology, MIRA - Institute for Biomedical 
      Technology and Technical Medicine, University of Twente, P.O. Box 217, 7500 AE 
      Enschede, The Netherlands.
FAU - van Putten, Michel J A M
AU  - van Putten MJAM
AD  - Department of Clinical Neurophysiology, MIRA - Institute for Biomedical 
      Technology and Technical Medicine, University of Twente, P.O. Box 217, 7500 AE 
      Enschede, The Netherlands.
AD  - Department of Neurology and Clinical Neurophysiology, Medisch Spectrum Twente, 
      P.O. Box 50000, 7500 KA Enschede, The Netherlands.
LA  - eng
PT  - Journal Article
DEP - 20161221
PL  - Netherlands
TA  - Clin Neurophysiol Pract
JT  - Clinical neurophysiology practice
JID - 101684308
PMC - PMC6123853
OTO - NOTNLM
OT  - Coil positioning
OT  - LICI
OT  - Long intracortical inhibition
OT  - Repeatability
OT  - TMS
OT  - Transcranial magnetic stimulation
EDAT- 2016/12/21 00:00
MHDA- 2016/12/21 00:01
PMCR- 2016/12/21
CRDT- 2018/09/15 06:00
PHST- 2016/10/14 00:00 [received]
PHST- 2016/11/13 00:00 [revised]
PHST- 2016/12/07 00:00 [accepted]
PHST- 2018/09/15 06:00 [entrez]
PHST- 2016/12/21 00:00 [pubmed]
PHST- 2016/12/21 00:01 [medline]
PHST- 2016/12/21 00:00 [pmc-release]
AID - S2467-981X(16)30024-5 [pii]
AID - 10.1016/j.cnp.2016.12.004 [doi]
PST - epublish
SO  - Clin Neurophysiol Pract. 2016 Dec 21;2:26-34. doi: 10.1016/j.cnp.2016.12.004. 
      eCollection 2017.