PMID- 30215548
OWN - NLM
STAT- MEDLINE
DCOM- 20190904
LR  - 20190904
IS  - 1563-5279 (Electronic)
IS  - 0020-7454 (Linking)
VI  - 129
IP  - 7
DP  - 2019 Jul
TI  - Homocysteine might increase the risk of recurrence in patients presenting with 
      primary cerebral infarction.
PG  - 654-659
LID - 10.1080/00207454.2018.1517762 [doi]
AB  - PURPOSE: Although hyperhomocysteinemia (Hhcy) is a risk factor for cerebral 
      infarction, its effect on recurrent cerebral infarction is less-defined. We aimed 
      to investigate the association of Hhcy and increased risk of recurrent cerebral 
      infarct. MATERIALS AND METHODS: From 2011 to 2013, we recruited 231 primary 
      cerebral infarct patients that were divided to a Hhcy group (n = 105) and a 
      control group (n = 126) according to plasma homocysteinemia (Hcy) levels 
      exceeding 15 mumol/L. In this prospective study, risk factors such as gender, age, 
      blood lipid and glucose levels, history of diabetes, high blood pressure, smoking 
      habits and plasma Hhcy levels were determined. A three-year follow-up compared 
      differences in cerebral infarction recurrence rates. Statistical analyses 
      identified whether plasma Hhcy levels were an independent risk factor for 
      recurrent cerebral infarction. RESULTS: Triglyceride and low-density lipoprotein 
      (LDL) levels in the Hhcy group were significantly higher than controls, and 
      cerebral infarct recurrence rates in the Hhcy group exceeded control subject 
      rates through the three-year follow-up (p = .021, p = .036 and p = .025). Cox 
      proportional hazards modeling showed that elevated Hhcy levels (hazard ratio 
      [HR] = 3.062, p < .001), increased age (HR = 1.069, p < .01), circulating 
      triglyceride levels (HR = 1.686, p = .048), and relative National Institutes of 
      Health Stroke (NIHSS) score (HR = 1.068, p = .016) were risk factors for 
      recurrent cerebral infarction. CONCLUSIONS: Level of Hhcy was a risk factor for 
      recurrent cerebral infarction. Further, particular demographic and clinical 
      outcomes including age, relative NIHSS scores, and circulating triglyceride 
      levels were markedly associated with the occurrence of cerebral infarction.
FAU - Anniwaer, Jianati
AU  - Anniwaer J
AD  - a Department of Critical Medicine , The People's Hospital of Xinjiang Uygur 
      Autonomous Region , Urumqi , China.
FAU - Liu, Meng-Zhuang
AU  - Liu MZ
AD  - b Department of General Medicine , The People's Hospital of Xinjiang Uygur 
      Autonomous Region , Urumqi , China.
FAU - Xue, Ke-Dong
AU  - Xue KD
AD  - a Department of Critical Medicine , The People's Hospital of Xinjiang Uygur 
      Autonomous Region , Urumqi , China.
FAU - Maimaiti, Abuduzhayier
AU  - Maimaiti A
AD  - b Department of General Medicine , The People's Hospital of Xinjiang Uygur 
      Autonomous Region , Urumqi , China.
FAU - Xiamixiding, Aersilan
AU  - Xiamixiding A
AD  - a Department of Critical Medicine , The People's Hospital of Xinjiang Uygur 
      Autonomous Region , Urumqi , China.
LA  - eng
PT  - Journal Article
DEP - 20190308
PL  - England
TA  - Int J Neurosci
JT  - The International journal of neuroscience
JID - 0270707
RN  - 0 (Biomarkers)
RN  - 0LVT1QZ0BA (Homocysteine)
RN  - Homocysteinemia
SB  - IM
MH  - Aged
MH  - Biomarkers/blood
MH  - Cerebral Infarction/*blood/epidemiology/etiology
MH  - Female
MH  - Homocysteine/*blood
MH  - Humans
MH  - Hyperhomocysteinemia/*complications/epidemiology
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Recurrence
MH  - Risk Factors
OTO - NOTNLM
OT  - Chinese
OT  - Homocysteine
OT  - cerebral infarction
OT  - prospective follow-up study
OT  - recurrent
EDAT- 2018/09/15 06:00
MHDA- 2019/09/05 06:00
CRDT- 2018/09/15 06:00
PHST- 2018/09/15 06:00 [pubmed]
PHST- 2019/09/05 06:00 [medline]
PHST- 2018/09/15 06:00 [entrez]
AID - 10.1080/00207454.2018.1517762 [doi]
PST - ppublish
SO  - Int J Neurosci. 2019 Jul;129(7):654-659. doi: 10.1080/00207454.2018.1517762. Epub 
      2019 Mar 8.