PMID- 30215889
OWN - NLM
STAT- MEDLINE
DCOM- 20190306
LR  - 20190306
IS  - 1934-8258 (Electronic)
IS  - 1934-8258 (Linking)
VI  - 99
IP  - 1
DP  - 2018 Oct
TI  - Multicolor Fluorescence In Situ Hybridization (FISH) Approaches for Simultaneous 
      Analysis of the Entire Human Genome.
PG  - e70
LID - 10.1002/cphg.70 [doi]
AB  - Analysis of the organization of the human genome is vital for understanding 
      genetic diversity, human evolution, and disease pathogenesis. A number of 
      approaches, such as multicolor fluorescence in situ hybridization (FISH) assays, 
      cytogenomic microarray (CMA), and next-generation sequencing (NGS) technologies, 
      are available for simultaneous analysis of the entire human genome. Multicolor 
      FISH-based spectral karyotyping (SKY), multiplex FISH (M-FISH), and Rx-FISH may 
      provide rapid identification of interchromosomal and intrachromosomal 
      rearrangements as well as the origin of unidentified extrachromosomal elements. 
      Recent advances in molecular cytogenetics have made it possible to efficiently 
      examine the entire human genome in a single experiment at much higher resolution 
      and specificity using CMA and NGS technologies. Here, we present an overview of 
      the approaches available for genome-wide analyses. (c) 2018 by John Wiley & Sons, 
      Inc.
CI  - (c) 2018 John Wiley & Sons, Inc.
FAU - Zhang, Chengsheng
AU  - Zhang C
AD  - Jackson Laboratory for Genomic Medicine, Farmington, Connecticut.
FAU - Cerveira, Eliza
AU  - Cerveira E
AD  - Jackson Laboratory for Genomic Medicine, Farmington, Connecticut.
FAU - Rens, Willem
AU  - Rens W
AD  - University of Cambridge, Cambridge, United Kingdom.
FAU - Yang, Fengtang
AU  - Yang F
AD  - University of Cambridge, Cambridge, United Kingdom.
FAU - Lee, Charles
AU  - Lee C
AD  - Jackson Laboratory for Genomic Medicine, Farmington, Connecticut.
LA  - eng
PT  - Journal Article
DEP - 20180914
PL  - United States
TA  - Curr Protoc Hum Genet
JT  - Current protocols in human genetics
JID - 101287858
SB  - IM
MH  - Chromosome Painting/*methods
MH  - *Genome, Human
MH  - Genomics/*methods
MH  - High-Throughput Nucleotide Sequencing/*methods
MH  - Humans
MH  - In Situ Hybridization, Fluorescence/*methods
MH  - Spectral Karyotyping/*methods
OTO - NOTNLM
OT  - Rx-FISH
OT  - cytogenomic microarray
OT  - genome-wide analysis
OT  - multiplex FISH
OT  - next-generation sequencing
OT  - spectral karyotyping
EDAT- 2018/09/15 06:00
MHDA- 2019/03/07 06:00
CRDT- 2018/09/15 06:00
PHST- 2018/09/15 06:00 [pubmed]
PHST- 2019/03/07 06:00 [medline]
PHST- 2018/09/15 06:00 [entrez]
AID - 10.1002/cphg.70 [doi]
PST - ppublish
SO  - Curr Protoc Hum Genet. 2018 Oct;99(1):e70. doi: 10.1002/cphg.70. Epub 2018 Sep 
      14.