PMID- 30216639
OWN - NLM
STAT- MEDLINE
DCOM- 20190306
LR  - 20240403
IS  - 1526-9914 (Electronic)
IS  - 1526-9914 (Linking)
VI  - 19
IP  - 6
DP  - 2018 Nov
TI  - Using max standardized uptake value from positron emission tomography to assess 
      tumor responses after lung stereotactic body radiotherapy for different 
      prescriptions.
PG  - 226-233
LID - 10.1002/acm2.12453 [doi]
AB  - PURPOSE: To retrospectively investigate tumor responses of lung SBRT patients for 
      different prescriptions. To analyze the relation between optimal biologically 
      equivalent dose (BED) and tumor responses. METHODS AND MATERIALS: Tumor responses 
      after lung SBRT were compared by examining 48 treatments used four prescriptions. 
      This study used simplified tumor response criteria: (a) Complete Response (CR) - 
      post max SUV (SUV(post) ) after SBRT in the treated tumor region was almost the 
      same as the SUVs in the surrounding regions; (b) Partial Response (PR) - 
      SUV(post) was smaller than previous max SUV (SUV(pre) ), but was greater than the 
      SUVs in the surrounding regions; (c) No Response (NR) - SUV(post) was the same as 
      or greater than SUV(pre) . Some SUV(post) reported as mild or favorable responses 
      were classified as CR/PR. BED calculated using alpha/beta of 10 Gy were analyzed with 
      assessments of tumor responses for SBRT prescriptions. RESULTS: For the 
      prescriptions (9 Gy x 5, 10 Gy x 5, 11 Gy x 5, and 12 Gy x 4) historically 
      recommended by RTOG, we observed that higher BED(10) and lower tumor volume would 
      achieve a higher complete response rate. The highest complete response rate was 
      observed for smallest tumor volume (PTV(ave)  = 6.8 cc) with higher BED(10) 
      (105.6) of 12 Gy x 4 prescription. For 11 Gy x 5 prescription, the BED(10) 
      (115.5) was the highest, but its complete response rate (58%) was lower than 79% 
      of 12 Gy x 4 prescription. We observed the PTV(ave) of 11 Gy x 5 prescription was 
      more than double of the PTV(ave) of 12 Gy x 4 prescription. For the same lung 
      SBRT prescription (BED(10)  > 100) earlier staging tumor had more favorable local 
      control. CONCLUSION: We demonstrated post max SUV read from PET/CT could 
      efficiently and accurately assess tumor response after lung SBRT. Although SBRT 
      with prescriptions resulting in a BED(10)  > 100 experienced favorable tumor 
      responses for early staging cancer, escalation of BED(10) to higher levels would 
      be beneficial for lung cancer patients with later staging and larger volume 
      tumors.
CI  - (c) 2018 The Authors. Journal of Applied Clinical Medical Physics published by 
      Wiley Periodicals, Inc. on behalf of American Association of Physicists in 
      Medicine.
FAU - Ding, Meisong
AU  - Ding M
AD  - Department of Radiation Oncology, Tulane University Medical Center, New Orleans, 
      LA, USA.
FAU - Zollinger, William
AU  - Zollinger W
AD  - Northeast Louisiana Cancer Center, Monroe, LA, USA.
FAU - Ebeling, Robert
AU  - Ebeling R
AD  - Northeast Louisiana Cancer Center, Monroe, LA, USA.
FAU - Heard, David
AU  - Heard D
AD  - Northeast Louisiana Cancer Center, Monroe, LA, USA.
FAU - Posey, Ryan
AU  - Posey R
AD  - Northeast Louisiana Cancer Center, Monroe, LA, USA.
LA  - eng
PT  - Journal Article
DEP - 20180914
PL  - United States
TA  - J Appl Clin Med Phys
JT  - Journal of applied clinical medical physics
JID - 101089176
RN  - 0 (Radiopharmaceuticals)
RN  - 0Z5B2CJX4D (Fluorodeoxyglucose F18)
SB  - IM
MH  - Carcinoma, Non-Small-Cell Lung/diagnostic imaging/*pathology/surgery
MH  - Fluorodeoxyglucose F18
MH  - Follow-Up Studies
MH  - Humans
MH  - Image Processing, Computer-Assisted/*methods
MH  - Lung Neoplasms/diagnostic imaging/*pathology/surgery
MH  - Positron-Emission Tomography/*methods
MH  - Prognosis
MH  - Radiometry/methods
MH  - Radiopharmaceuticals
MH  - Radiosurgery/*methods
MH  - Radiotherapy Dosage
MH  - Radiotherapy Planning, Computer-Assisted/*methods
MH  - Radiotherapy, Intensity-Modulated/methods
MH  - Retrospective Studies
PMC - PMC6236840
OTO - NOTNLM
OT  - computed tomography (CT)
OT  - maximum standardized uptake value (SUV)
OT  - positron emission tomography (PET)
OT  - stereotactic body radiotherapy (SBRT)
OT  - tumor responses
EDAT- 2018/09/15 06:00
MHDA- 2019/03/07 06:00
PMCR- 2018/09/14
CRDT- 2018/09/15 06:00
PHST- 2018/03/27 00:00 [received]
PHST- 2018/06/06 00:00 [revised]
PHST- 2018/08/20 00:00 [accepted]
PHST- 2018/09/15 06:00 [pubmed]
PHST- 2019/03/07 06:00 [medline]
PHST- 2018/09/15 06:00 [entrez]
PHST- 2018/09/14 00:00 [pmc-release]
AID - ACM212453 [pii]
AID - 10.1002/acm2.12453 [doi]
PST - ppublish
SO  - J Appl Clin Med Phys. 2018 Nov;19(6):226-233. doi: 10.1002/acm2.12453. Epub 2018 
      Sep 14.