PMID- 30218674
OWN - NLM
STAT- MEDLINE
DCOM- 20190213
LR  - 20190215
IS  - 1873-7064 (Electronic)
IS  - 0028-3908 (Linking)
VI  - 141
DP  - 2018 Oct
TI  - Andrographolide ameliorates intracerebral hemorrhage induced secondary brain 
      injury by inhibiting neuroinflammation induction.
PG  - 305-315
LID - S0028-3908(18)30650-6 [pii]
LID - 10.1016/j.neuropharm.2018.09.015 [doi]
AB  - Microglia activation and neuroinflammation play important roles in intracerebral 
      hemorrhage (ICH)-induced secondary brain injury (SBI). In this study, we 
      attempted to investigate the potential effects of Andrographolide (Andro) on 
      ICH-induced SBI and the possible mechanisms behind these effects. Andro treatment 
      effectively reduced neuronal cell death and degeneration and alleviated 
      neurobehavioral disorders and brain edema in vivo. In an in vitro study, 
      microglia activation-induced neuronal cell death was ameliorated by Andro 
      treatment. In addition, microglia activation and neuroinflammation were induced 
      by ICH, exhibiting elevated cytokine levels, which could be reversed with Andro 
      treatment. The levels of TNF-alpha and IL-6 were significantly decreased after 
      treatment with Andro, both in vivo and in vitro, due to the inhibition of nuclear 
      transcription factor-kappaB (NF-kappaB) signaling pathway activation. Meanwhile, Andro 
      decreased the levels of IL-1beta and LDH, as well as microglia pyroptosis induced by 
      ICH by suppressing the assembly of the nucleotide-binding oligomerization domain 
      like receptor protein 3 (NLRP3) inflammasome. In summary, this study reveals an 
      anti-inflammatory effect of Andro and its potential mechanisms, and it shows that 
      Andro is a potential candidate for improving ICH-induced SBI.
CI  - Copyright (c) 2018 Elsevier Ltd. All rights reserved.
FAU - Li, Xiang
AU  - Li X
AD  - Department of Neurosurgery & Brain and Nerve Research Laboratory, The First 
      Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou, 215006, 
      China.
FAU - Wang, Tianyi
AU  - Wang T
AD  - Department of Neurosurgery & Brain and Nerve Research Laboratory, The First 
      Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou, 215006, 
      China.
FAU - Zhang, Dongping
AU  - Zhang D
AD  - Department of Neurosurgery & Brain and Nerve Research Laboratory, The First 
      Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou, 215006, 
      China.
FAU - Li, Haiying
AU  - Li H
AD  - Department of Neurosurgery & Brain and Nerve Research Laboratory, The First 
      Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou, 215006, 
      China.
FAU - Shen, Haitao
AU  - Shen H
AD  - Department of Neurosurgery & Brain and Nerve Research Laboratory, The First 
      Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou, 215006, 
      China.
FAU - Ding, Xin
AU  - Ding X
AD  - Division of Neonatology, Children's Hospital of Soochow University, 92 Zhongnan 
      Street, Suzhou, 215003, China. Electronic address: dingxin@suda.edu.cn.
FAU - Chen, Gang
AU  - Chen G
AD  - Department of Neurosurgery & Brain and Nerve Research Laboratory, The First 
      Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou, 215006, 
      China. Electronic address: nju_neurosurgery@163.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180912
PL  - England
TA  - Neuropharmacology
JT  - Neuropharmacology
JID - 0236217
RN  - 0 (Cytokines)
RN  - 0 (Diterpenes)
RN  - 0 (Interleukin-1beta)
RN  - 0 (Interleukin-6)
RN  - 0 (NF-kappa B)
RN  - 0 (NLR Family, Pyrin Domain-Containing 3 Protein)
RN  - 0 (Neuroprotective Agents)
RN  - 0 (Nlrp3 protein, rat)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 410105JHGR (andrographolide)
RN  - EC 1.1.1.27 (L-Lactate Dehydrogenase)
SB  - IM
MH  - Animals
MH  - Brain Edema/prevention & control
MH  - Brain Injuries/*complications/*drug therapy/metabolism
MH  - Cell Death/drug effects
MH  - Cerebral Hemorrhage/*complications/*drug therapy/metabolism
MH  - Cytokines/metabolism
MH  - Diterpenes/*pharmacology
MH  - Inflammation/*complications/metabolism/*prevention & control
MH  - Interleukin-1beta/metabolism
MH  - Interleukin-6/metabolism
MH  - L-Lactate Dehydrogenase/metabolism
MH  - Male
MH  - Microglia/metabolism
MH  - NF-kappa B/metabolism
MH  - NLR Family, Pyrin Domain-Containing 3 Protein/metabolism
MH  - Nerve Degeneration/prevention & control
MH  - Neurons/drug effects
MH  - Neuroprotective Agents/pharmacology
MH  - Pyroptosis/drug effects
MH  - Rats
MH  - Signal Transduction/drug effects
MH  - Tumor Necrosis Factor-alpha/metabolism
OTO - NOTNLM
OT  - Andrographolide
OT  - Intracerebral hemorrhage
OT  - NF-kappaB
OT  - Neuroinflammation
OT  - Pyroptosis
OT  - Secondary brain injury
EDAT- 2018/09/16 06:00
MHDA- 2019/02/14 06:00
CRDT- 2018/09/16 06:00
PHST- 2018/04/14 00:00 [received]
PHST- 2018/09/07 00:00 [revised]
PHST- 2018/09/11 00:00 [accepted]
PHST- 2018/09/16 06:00 [pubmed]
PHST- 2019/02/14 06:00 [medline]
PHST- 2018/09/16 06:00 [entrez]
AID - S0028-3908(18)30650-6 [pii]
AID - 10.1016/j.neuropharm.2018.09.015 [doi]
PST - ppublish
SO  - Neuropharmacology. 2018 Oct;141:305-315. doi: 10.1016/j.neuropharm.2018.09.015. 
      Epub 2018 Sep 12.