PMID- 30219561
OWN - NLM
STAT- MEDLINE
DCOM- 20190910
LR  - 20190910
IS  - 1879-1379 (Electronic)
IS  - 0022-3956 (Linking)
VI  - 105
DP  - 2018 Oct
TI  - The effect of exercise on resting concentrations of peripheral brain-derived 
      neurotrophic factor (BDNF) in major depressive disorder: A meta-analysis.
PG  - 123-131
LID - S0022-3956(18)30353-4 [pii]
LID - 10.1016/j.jpsychires.2018.08.021 [doi]
AB  - Exercise interventions have been shown to successfully improve depression in 
      patients with major depressive disorder (MDD), but like other forms of 
      antidepressant treatment, exercise is not effective in all patients and its 
      mechanisms of action have not been fully elucidated. Brain-derived neurotrophic 
      factor (BDNF), a key mediator of neurogenesis and neuronal survival, has been 
      shown to be decreased in individuals with MDD. One potential mechanism by which 
      exercise alleviates depression is through an increase in BDNF. In order to 
      evaluate this hypothesis, we conducted a meta-analysis of studies that assessed 
      the effects of a chronic (multi-week) exercise intervention on BDNF 
      concentrations in MDD patients. MEDLINE, Embase, PsycINFO, SPORTDiscus, 
      Rehabilitation & Sports Medicine Source, and CINAHL databases were searched for 
      original, peer-reviewed reports of peripheral blood BDNF concentrations before 
      and after a chronic exercise intervention in MDD patients. Standardized mean 
      differences (SMDs) were generated from random effects models. Potential sources 
      of heterogeneity were explored in meta-regression analyses. In six studies that 
      met inclusion criteria, resting blood concentrations of BDNF were not 
      significantly higher after a chronic exercise intervention (SMD = 0.43, 95% CI: 
      -0.06-0.92, p = 0.09) in MDD patients. This meta-analysis did not find evidence 
      that a chronic aerobic exercise intervention increases resting concentrations of 
      BDNF in the blood of MDD patients; however, there is a lack of studies in this 
      area making it difficult to reach a definitive conclusion. Future studies on this 
      topic with larger sample sizes and longer durations are needed to draw more 
      robust conclusions.
CI  - Copyright (c) 2018 Elsevier Ltd. All rights reserved.
FAU - Dinoff, Adam
AU  - Dinoff A
AD  - Neuropsychopharmacology Research Group, Hurvitz Brain Sciences Program, 
      Sunnybrook Research Institute, 2075 Bayview Avenue, Toronto, Ontario, M4N 3M5, 
      Canada.
FAU - Herrmann, Nathan
AU  - Herrmann N
AD  - Neuropsychopharmacology Research Group, Hurvitz Brain Sciences Program, 
      Sunnybrook Research Institute, 2075 Bayview Avenue, Toronto, Ontario, M4N 3M5, 
      Canada; Department of Psychiatry, Faculty of Medicine, University of Toronto, 250 
      College Street, Toronto, Ontario, M5T 1R8, Canada. Electronic address: 
      Nathan.Herrmann@sunnybrook.ca.
FAU - Swardfager, Walter
AU  - Swardfager W
AD  - Department of Pharmacology and Toxicology, Faculty of Medicine, University of 
      Toronto, 1 King's College Circle, Toronto, Ontario, M5S 1A8, Canada.
FAU - Gallagher, Damien
AU  - Gallagher D
AD  - Neuropsychopharmacology Research Group, Hurvitz Brain Sciences Program, 
      Sunnybrook Research Institute, 2075 Bayview Avenue, Toronto, Ontario, M4N 3M5, 
      Canada; Department of Psychiatry, Faculty of Medicine, University of Toronto, 250 
      College Street, Toronto, Ontario, M5T 1R8, Canada.
FAU - Lanctot, Krista L
AU  - Lanctot KL
AD  - Neuropsychopharmacology Research Group, Hurvitz Brain Sciences Program, 
      Sunnybrook Research Institute, 2075 Bayview Avenue, Toronto, Ontario, M4N 3M5, 
      Canada; Department of Psychiatry, Faculty of Medicine, University of Toronto, 250 
      College Street, Toronto, Ontario, M5T 1R8, Canada; Department of Pharmacology and 
      Toxicology, Faculty of Medicine, University of Toronto, 1 King's College Circle, 
      Toronto, Ontario, M5S 1A8, Canada.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Systematic Review
DEP - 20180906
PL  - England
TA  - J Psychiatr Res
JT  - Journal of psychiatric research
JID - 0376331
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Adult
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Depressive Disorder, Major/*blood/*therapy
MH  - Exercise/*physiology
MH  - Exercise Therapy/*methods
MH  - Female
MH  - Humans
MH  - Male
OTO - NOTNLM
OT  - BDNF
OT  - Brain-derived neurotrophic factor
OT  - Depression
OT  - Exercise
OT  - Major depressive disorder
OT  - Meta-analysis
EDAT- 2018/09/17 06:00
MHDA- 2019/09/11 06:00
CRDT- 2018/09/17 06:00
PHST- 2018/03/14 00:00 [received]
PHST- 2018/08/09 00:00 [revised]
PHST- 2018/08/30 00:00 [accepted]
PHST- 2018/09/17 06:00 [pubmed]
PHST- 2019/09/11 06:00 [medline]
PHST- 2018/09/17 06:00 [entrez]
AID - S0022-3956(18)30353-4 [pii]
AID - 10.1016/j.jpsychires.2018.08.021 [doi]
PST - ppublish
SO  - J Psychiatr Res. 2018 Oct;105:123-131. doi: 10.1016/j.jpsychires.2018.08.021. 
      Epub 2018 Sep 6.