PMID- 30219569
OWN - NLM
STAT- MEDLINE
DCOM- 20190401
LR  - 20190401
IS  - 1873-1708 (Electronic)
IS  - 0890-6238 (Linking)
VI  - 82
DP  - 2018 Dec
TI  - Effect of endocrine disruptors on the ratio of X and Y chromosome-bearing live 
      spermatozoa.
PG  - 10-17
LID - S0890-6238(18)30155-2 [pii]
LID - 10.1016/j.reprotox.2018.09.002 [doi]
AB  - Although equal numbers of X and Y spermatozoa are produced during 
      spermatogenesis, the sex chromosome ratio in ejaculated spermatozoa can be 
      altered by exposure to endocrine-disrupting chemicals (EDCs), which can be 
      reflected by altered sex ratios at birth. Here, we hypothesized EDCs affect sperm 
      functions and viability of X and Y chromosome-bearing human spermatozoa. After 
      exposure to genistein (Gen), bisphenol A (BPA), 
      2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), dibromochloropropane (DBCP), and 
      diazinon (Diaz), we evaluated motility, viability, capacitation, and differential 
      viability of X and Y spermatozoa. All EDCs tested altered sperm viability, 
      motility, and capacitation. Interestingly, the Y/X ratio of live spermatozoa was 
      significantly lower in sperm treated with TCDD, DBCP, and Diaz than control 
      spermatozoa. Our results suggest that some of EDCs have larger effects on the 
      viability of Y spermatozoa than X spermatozoa, implicating that a reduction in Y 
      sperm viability may result in a female-biased sex ratio of offspring at birth.
CI  - Copyright (c) 2018 Elsevier Inc. All rights reserved.
FAU - Song, Won-Hee
AU  - Song WH
AD  - Department of Animal Science and Technology, Chung-Ang University, Anseong, 
      Gyeonggi-Do 17546, Republic of Korea.
FAU - Mohamed, Elsayed A
AU  - Mohamed EA
AD  - Department of Animal Science and Technology, Chung-Ang University, Anseong, 
      Gyeonggi-Do 17546, Republic of Korea.
FAU - Pang, Won-Ki
AU  - Pang WK
AD  - Department of Animal Science and Technology, Chung-Ang University, Anseong, 
      Gyeonggi-Do 17546, Republic of Korea.
FAU - Kang, Kyu-Ho
AU  - Kang KH
AD  - Department of Animal Science and Technology, Chung-Ang University, Anseong, 
      Gyeonggi-Do 17546, Republic of Korea.
FAU - Ryu, Do-Yeal
AU  - Ryu DY
AD  - Department of Animal Science and Technology, Chung-Ang University, Anseong, 
      Gyeonggi-Do 17546, Republic of Korea.
FAU - Rahman, Md Saidur
AU  - Rahman MS
AD  - Department of Animal Science and Technology, Chung-Ang University, Anseong, 
      Gyeonggi-Do 17546, Republic of Korea.
FAU - Pang, Myung-Geol
AU  - Pang MG
AD  - Department of Animal Science and Technology, Chung-Ang University, Anseong, 
      Gyeonggi-Do 17546, Republic of Korea. Electronic address: mgpang@cau.ac.kr.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180913
PL  - United States
TA  - Reprod Toxicol
JT  - Reproductive toxicology (Elmsford, N.Y.)
JID - 8803591
RN  - 0 (Benzhydryl Compounds)
RN  - 0 (Endocrine Disruptors)
RN  - 0 (Phenols)
RN  - 0 (Polychlorinated Dibenzodioxins)
RN  - 96K0FD4803 (1,2-dibromo-3-chloropropane)
RN  - DH2M523P0H (Genistein)
RN  - MLT3645I99 (bisphenol A)
RN  - T75W9911L6 (Propane)
RN  - YUS1M1Q929 (Diazinon)
SB  - IM
MH  - Benzhydryl Compounds/toxicity
MH  - *Chromosomes, Human, X
MH  - *Chromosomes, Human, Y
MH  - Diazinon/toxicity
MH  - Endocrine Disruptors/*toxicity
MH  - Genistein/toxicity
MH  - Humans
MH  - Male
MH  - Phenols/toxicity
MH  - Polychlorinated Dibenzodioxins/toxicity
MH  - Propane/analogs & derivatives/toxicity
MH  - Sex Ratio
MH  - Sperm Motility/drug effects
MH  - Spermatozoa/*drug effects
OTO - NOTNLM
OT  - Endocrine-disrupting chemical
OT  - Sex chromosome
OT  - Sex ratio
OT  - Sperm functions
OT  - Spermatozoa
EDAT- 2018/09/17 06:00
MHDA- 2019/04/02 06:00
CRDT- 2018/09/17 06:00
PHST- 2018/04/20 00:00 [received]
PHST- 2018/06/07 00:00 [revised]
PHST- 2018/09/06 00:00 [accepted]
PHST- 2018/09/17 06:00 [pubmed]
PHST- 2019/04/02 06:00 [medline]
PHST- 2018/09/17 06:00 [entrez]
AID - S0890-6238(18)30155-2 [pii]
AID - 10.1016/j.reprotox.2018.09.002 [doi]
PST - ppublish
SO  - Reprod Toxicol. 2018 Dec;82:10-17. doi: 10.1016/j.reprotox.2018.09.002. Epub 2018 
      Sep 13.