PMID- 30220011
OWN - NLM
STAT- MEDLINE
DCOM- 20190624
LR  - 20231213
IS  - 1559-0755 (Electronic)
IS  - 0257-277X (Linking)
VI  - 66
IP  - 5
DP  - 2018 Oct
TI  - Biological predictors shared by dementia and bullous pemphigoid patients point 
      out a cross-antigenicity between BP180/BP230 brain and skin isoforms.
PG  - 567-576
LID - 10.1007/s12026-018-9028-1 [doi]
AB  - Bullous pemphigoid (BP) following dementia diagnosis has been reported in the 
      elderly. Skin and brain tissues express BP180 and BP230 isoforms. Dementia has 
      been associated with rs6265 (Val66Met) polymorphism of the brain-derived 
      neurotrophic factor (BDNF) gene and low serum BDNF. Here we investigated a 
      possible cross-antigenicity between BP180/BP230 brain and skin isoforms. We 
      assessed antibodies against BP180/BP230 and BDNF levels by ELISA and BDNF 
      Val66Met SNP by PCR in three groups: 50 BP patients, 50 patients with dementia, 
      and 50 elderly controls. Heatmap hierarchical clustering and data mining decision 
      tree were used to analyze the patients' demographic and laboratorial data as 
      predictors of dementia-BP association. Sixteen percent of BP patients with the 
      lowest serological BDNF presented dementia-BP clinical association. 
      Anti-BP180/230 positivity was unexpected observed among dementia patients (10%, 
      10%) and controls (14%, 1%). Indirect immunofluorescence using healthy human skin 
      showed a BP pattern in two of 10 samples containing antibodies against 
      BP180/BP230 obtained from dementia group but not in the control samples. Neither 
      allelic nor genotypic BDNF Val66Met SNP was associated with dementia or with BP 
      (associated or not with clinical manifestation of dementia). Heatmap analysis was 
      able to differentiate the three studied groups and confirmed the ELISA results. 
      The comprehensive data mining analysis revealed that BP patients and dementia 
      patients shared biological predictors that justified the dementia-BP association. 
      Autoantibodies against the BP180/BP230 brain isoforms produced by dementia 
      patients could cross-react with the BP180/BP230 skin isoforms, which could 
      justify cases of dementia preceding the BP disease.
FAU - Julio, Tamiris A
AU  - Julio TA
AUID- ORCID: 0000-0002-0536-9726
AD  - Division of Dermatology, Department of Medical Clinics, Ribeirao Preto Medical 
      School, University of Sao Paulo, Av. Bandeirantes, 3900, Ribeirao Preto, Sao 
      Paulo, 14049-900, Brazil.
FAU - Vernal, Sebastian
AU  - Vernal S
AD  - Division of Dermatology, Department of Medical Clinics, Ribeirao Preto Medical 
      School, University of Sao Paulo, Av. Bandeirantes, 3900, Ribeirao Preto, Sao 
      Paulo, 14049-900, Brazil.
FAU - Massaro, Juliana D
AU  - Massaro JD
AD  - Division of Clinical Immunology, Department of Medical Clinics, Ribeirao Preto 
      Medical School, University of Sao Paulo, Ribeirao Preto, Brazil.
FAU - Silva, Matheus C
AU  - Silva MC
AD  - Division of Clinical Immunology, Department of Medical Clinics, Ribeirao Preto 
      Medical School, University of Sao Paulo, Ribeirao Preto, Brazil.
FAU - Donadi, Eduardo A
AU  - Donadi EA
AD  - Division of Clinical Immunology, Department of Medical Clinics, Ribeirao Preto 
      Medical School, University of Sao Paulo, Ribeirao Preto, Brazil.
FAU - Moriguti, Julio C
AU  - Moriguti JC
AD  - Division of Gerontology, Department of Medical Clinics, Ribeirao Preto Medical 
      School, University of Sao Paulo, Ribeirao Preto, Brazil.
FAU - Roselino, Ana M
AU  - Roselino AM
AD  - Division of Dermatology, Department of Medical Clinics, Ribeirao Preto Medical 
      School, University of Sao Paulo, Av. Bandeirantes, 3900, Ribeirao Preto, Sao 
      Paulo, 14049-900, Brazil. amfrosel@fmrp.usp.br.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Immunol Res
JT  - Immunologic research
JID - 8611087
RN  - 0 (Autoantibodies)
RN  - 0 (Autoantigens)
RN  - 0 (Biomarkers)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (DST protein, human)
RN  - 0 (Dystonin)
RN  - 0 (Non-Fibrillar Collagens)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Aged
MH  - Autoantibodies/blood
MH  - Autoantigens/immunology/*metabolism
MH  - Biomarkers/blood
MH  - Brain/*metabolism
MH  - Brain-Derived Neurotrophic Factor/blood/genetics
MH  - Cross Reactions
MH  - Dementia/complications/*diagnosis/immunology
MH  - Dystonin/immunology/*metabolism
MH  - Female
MH  - Humans
MH  - Male
MH  - Non-Fibrillar Collagens/immunology/*metabolism
MH  - Pemphigoid, Bullous/complications/*diagnosis/immunology
MH  - Polymorphism, Single Nucleotide/genetics
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Skin/*metabolism
MH  - Collagen Type XVII
OTO - NOTNLM
OT  - BDNF
OT  - BP180/BP230
OT  - Bullous pemphigoid
OT  - Data mining decision tree
OT  - Dementia
OT  - Heatmap hierarchical clustering
EDAT- 2018/09/17 06:00
MHDA- 2019/06/25 06:00
CRDT- 2018/09/17 06:00
PHST- 2018/09/17 06:00 [pubmed]
PHST- 2019/06/25 06:00 [medline]
PHST- 2018/09/17 06:00 [entrez]
AID - 10.1007/s12026-018-9028-1 [pii]
AID - 10.1007/s12026-018-9028-1 [doi]
PST - ppublish
SO  - Immunol Res. 2018 Oct;66(5):567-576. doi: 10.1007/s12026-018-9028-1.