PMID- 30220125
OWN - NLM
STAT- MEDLINE
DCOM- 20181009
LR  - 20181023
IS  - 0529-5807 (Print)
IS  - 0529-5807 (Linking)
VI  - 47
IP  - 9
DP  - 2018 Sep 8
TI  - [Myxoid variant of angiomatoid fibrous histiocytoma: a clinicopathologic analysis 
      of 3 cases].
PG  - 700-705
LID - 10.3760/cma.j.issn.0529-5807.2018.09.010 [doi]
AB  - Objective: To study clinicopathologic features, diagnosis and differential 
      diagnosis of myxoid variant of angiomatoid fibrous histiocytoma (AFH). Methods: 
      Three cases of myxoid variant of AFHs were collected from First Affiliated 
      Hospital of Nanjing Medical University during 2008 and 2017. EnVision method and 
      fluorescence in situ hybridization(FISH) were used to detect immunophenotype and 
      EWSR1 gene rearrangement, respectively. Results: There were 2 males and l female 
      with age at 13, 31, and 42 years, respectively. The patients presented with a 
      painless mass located superficially (subcutaneous or submucosal) in two cases or 
      deep-seated (retroperitoneum) in one case. Grossly, the diameters of tumors were 
      1, 7, and 2 cm, respectively. The cut surface was solid and firm, tan to gray in 
      colour. Histologically, the circumscribed tumor had fibrous pseudocapsule and 
      peritumoal lymphoplasmacytic infiltrates. The tumor cells arranged in vaguely 
      nodular growth pattern, with prominent myxoid stroma (present in 60% to 100% of 
      the entire tumor). In hypocellular myxoid areas, the spindle to stellate tumor 
      cells arranged in cords or reticular pattern, or in a haphazard manner. However, 
      histiocytoid cells arranged in fascicular, sheet-like, or whorled growth pattern, 
      as in classical AFH, were also identified in hypercelluar areas. Mild to moderate 
      atypia was observed with low mitotic rate of (0-2)/10 HPF. Tumor necrosis was not 
      seen. One case presented with slit-like hemorrhage and sclerosing collagen 
      intermingled with myxoid matrix was identified in 1 case. Immunohistochemically, 
      all cases were positive for CD68 and CD163. Two of three were positive for 
      desmin, EMA, CD99 and one for Calponin, SMA. All cases were negative for S-100 
      protein, CD34, CD31, CD35, CD21 and CKpan. FISH detection was positive for EWSRl 
      gene in all cases. Available clinical follow-up was obtained in 2 cases, 
      revealing no evidence of disease in 6 and 89 months, respectively. Conclusions: 
      Myxoid variant of AFH is a histological subtype of AFH, with clinical features, 
      immunophenotypes, genomic profiles and biological behavior similar to typical 
      AFH. Their unusual morphology is easily confused with a variety of other myxoid 
      mesenchymal neoplasms, including myoepithelioma and nerve sheath tumors.
FAU - Gong, Q X
AU  - Gong QX
AD  - Department of Pathology, First Affiliated Hospital of Nanjing Medical University, 
      Nanjing 210029, China.
FAU - Zhang, Z H
AU  - Zhang ZH
FAU - Fan, Q H
AU  - Fan QH
LA  - chi
GR  - S201519/Suqian Science and Technology Supporting Plan of Jiangsu Province/
PT  - Case Reports
PT  - Journal Article
PL  - China
TA  - Zhonghua Bing Li Xue Za Zhi
JT  - Zhonghua bing li xue za zhi = Chinese journal of pathology
JID - 0005331
RN  - 0 (12E7 Antigen)
RN  - 0 (Antigens, CD)
RN  - 0 (Antigens, Differentiation, Myelomonocytic)
RN  - 0 (CD163 antigen)
RN  - 0 (CD99 protein, human)
RN  - 0 (Calmodulin-Binding Proteins)
RN  - 0 (Desmin)
RN  - 0 (EWSR1 protein, human)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (RNA-Binding Protein EWS)
RN  - 0 (Receptors, Cell Surface)
RN  - Histiocytoma, Angiomatoid Fibrous
SB  - IM
MH  - 12E7 Antigen/analysis
MH  - Adolescent
MH  - Adult
MH  - Antigens, CD/analysis
MH  - Antigens, Differentiation, Myelomonocytic/analysis
MH  - Calmodulin-Binding Proteins
MH  - Desmin/analysis
MH  - Diagnosis, Differential
MH  - Female
MH  - Gene Rearrangement
MH  - Histiocytoma, Malignant Fibrous/chemistry/genetics/*pathology
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Neoplasm Proteins/analysis
MH  - RNA-Binding Protein EWS/genetics
MH  - Receptors, Cell Surface/analysis
OTO - NOTNLM
OT  - Histiocytoma, benign fibrous
OT  - In situ hybridization, fluorescence
OT  - Mucus
OT  - Soft tissue neoplasms
EDAT- 2018/09/18 06:00
MHDA- 2018/10/10 06:00
CRDT- 2018/09/18 06:00
PHST- 2018/09/18 06:00 [entrez]
PHST- 2018/09/18 06:00 [pubmed]
PHST- 2018/10/10 06:00 [medline]
AID - 10.3760/cma.j.issn.0529-5807.2018.09.010 [doi]
PST - ppublish
SO  - Zhonghua Bing Li Xue Za Zhi. 2018 Sep 8;47(9):700-705. doi: 
      10.3760/cma.j.issn.0529-5807.2018.09.010.