PMID- 30221072
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220321
IS  - 2164-2591 (Print)
IS  - 2164-2591 (Electronic)
IS  - 2164-2591 (Linking)
VI  - 7
IP  - 5
DP  - 2018 Sep
TI  - Pattern Electroretinogram Detects Localized Glaucoma Defects.
PG  - 6
LID - 10.1167/tvst.7.5.6 [doi]
LID - 6
AB  - PURPOSE: We evaluated the clinical ability of pattern electroretinogram (PERG) to 
      detect functional losses in the affected hemifield of open-angle glaucoma 
      patients with localized perimetric defects. METHODS: Hemifield 
      (horizontally-defined) steady-state PERGs (h-PERGs) were recorded in response to 
      1.7 c/deg alternating gratings from 32 eyes of 29 glaucomatous patients with a 
      perimetric, focal one-hemifield defect, 10 eyes of 10 glaucomatous patients with 
      a diffuse perimetric defect, and 18 eyes of 18 age-matched normal subjects. 
      Standard automated perimetry (SAP) and spectral-domain optical coherence 
      tomography (SD-OCT) for retinal nerve fiber layer (RNFL) thickness also were 
      performed. h-PERG amplitudes and ratios, calculated corresponding hemifield 
      perimetric deviations, as well as hemiretina RNFL thicknesses were analyzed. 
      RESULTS: h-PERG amplitudes, perimetric deviations, and RNFL thicknesses showed 
      losses (P < 0.001) when comparing affected with unaffected hemifields of 
      localized glaucomatous eyes. No differences were found in h-PERG amplitudes 
      between hemifields of normal or diffuse glaucomatous eyes. h-PERG amplitude 
      ratios (affected/unaffected hemifield) in localized glaucoma were lower (P < 
      0.001) than the ratios from normal or diffuse glaucomatous eyes. The areas under 
      the receiver operating characteristic curves for h-PERG amplitude ratios, 
      comparing localized-defect glaucomatous eyes with normal or diffuse glaucomatous 
      eyes, were 0.93 and 0.91, respectively. CONCLUSIONS: h-PERG assessment showed 
      good diagnostic accuracy to confirm localized glaucomatous defects detected 
      perimetrically. This test may be particularly useful in cognitively impaired 
      patients or young/nonverbal patients unable to provide reliable visual fields. 
      TRANSLATIONAL RELEVANCE: h-PERG provides a sensitive objective measure to confirm 
      focal losses detected with SAP and/or RNFL thickness analysis.
FAU - Salgarello, Tommaso
AU  - Salgarello T
AD  - 1Institute of Ophthalmology, Fondazione Policlinico Universitario A. Gemelli 
      IRCCS, Roma, Italia.
FAU - Giudiceandrea, Andrea
AU  - Giudiceandrea A
AD  - 1Institute of Ophthalmology, Fondazione Policlinico Universitario A. Gemelli 
      IRCCS, Roma, Italia.
AD  - 2Institute of Ophthalmology, Universita Cattolica del Sacro Cuore, Roma, Italia.
FAU - Calandriello, Luigi
AU  - Calandriello L
AD  - 1Institute of Ophthalmology, Fondazione Policlinico Universitario A. Gemelli 
      IRCCS, Roma, Italia.
AD  - 2Institute of Ophthalmology, Universita Cattolica del Sacro Cuore, Roma, Italia.
FAU - Marangoni, Dario
AU  - Marangoni D
AD  - 1Institute of Ophthalmology, Fondazione Policlinico Universitario A. Gemelli 
      IRCCS, Roma, Italia.
AD  - 2Institute of Ophthalmology, Universita Cattolica del Sacro Cuore, Roma, Italia.
FAU - Colotto, Alberto
AU  - Colotto A
AD  - 2Institute of Ophthalmology, Universita Cattolica del Sacro Cuore, Roma, Italia.
FAU - Caporossi, Aldo
AU  - Caporossi A
AD  - 1Institute of Ophthalmology, Fondazione Policlinico Universitario A. Gemelli 
      IRCCS, Roma, Italia.
AD  - 2Institute of Ophthalmology, Universita Cattolica del Sacro Cuore, Roma, Italia.
FAU - Falsini, Benedetto
AU  - Falsini B
AD  - 1Institute of Ophthalmology, Fondazione Policlinico Universitario A. Gemelli 
      IRCCS, Roma, Italia.
AD  - 2Institute of Ophthalmology, Universita Cattolica del Sacro Cuore, Roma, Italia.
LA  - eng
PT  - Journal Article
DEP - 20180913
PL  - United States
TA  - Transl Vis Sci Technol
JT  - Translational vision science & technology
JID - 101595919
PMC - PMC6136848
OTO - NOTNLM
OT  - electroretinogram
OT  - glaucoma
OT  - hemifield
OT  - hemiretina
OT  - localized defect
EDAT- 2018/09/18 06:00
MHDA- 2018/09/18 06:01
PMCR- 2018/09/13
CRDT- 2018/09/18 06:00
PHST- 2017/12/15 00:00 [received]
PHST- 2018/06/19 00:00 [accepted]
PHST- 2018/09/18 06:00 [entrez]
PHST- 2018/09/18 06:00 [pubmed]
PHST- 2018/09/18 06:01 [medline]
PHST- 2018/09/13 00:00 [pmc-release]
AID - TVST-17-0676 [pii]
AID - 10.1167/tvst.7.5.6 [doi]
PST - epublish
SO  - Transl Vis Sci Technol. 2018 Sep 13;7(5):6. doi: 10.1167/tvst.7.5.6. eCollection 
      2018 Sep.