PMID- 30221695
OWN - NLM
STAT- MEDLINE
DCOM- 20190125
LR  - 20190125
IS  - 1791-3004 (Electronic)
IS  - 1791-2997 (Print)
IS  - 1791-2997 (Linking)
VI  - 18
IP  - 5
DP  - 2018 Nov
TI  - CXCL12 induces migration of oligodendrocyte precursor cells through the 
      CXCR4‑activated MEK/ERK and PI3K/AKT pathways.
PG  - 4374-4380
LID - 10.3892/mmr.2018.9444 [doi]
AB  - Demyelination is a nervous system disease in which the myelin sheaths of neurons 
      are damaged due to inflammatory reactions, inherited abnormalities or trauma. 
      This damage impairs the conduction of signals in the affected nerves, which in 
      turn causes deficiencies in sensation, movement and cognition. Oligodendrocyte 
      precursor cells (OPCs) are able to induce remyelination. However, the 
      remyelination is suboptimal due to the limited migration of OPCs. In the present 
      study, neonatal OPCs were isolated from rats for the investigation of the role of 
      C‑X‑C motif chemokine ligand 12 (CXCL12), an important chemokine, in mediating 
      the migration ability of OPCs. The present results demonstrated that CXCL12 
      stimulation markedly promoted the migration of OPCs and activated the dual 
      specificity mitogen‑activated protein kinase kinase 1 (MEK)/extracellular 
      signal‑regulated kinase (ERK) and phosphoinositide 3‑kinase (PI3K)/RAC‑alpha 
      serine/threonine‑protein kinase (AKT) pathways. Knockdown of C‑X‑C motif 
      chemokine receptor 4 (CXCR4; a receptor of CXCL12) reversed the CXCL12‑induced 
      migration of OPCs and blocked the MEK/ERK and PI3K/AKT pathways. In addition, 
      specific inhibitors of the MEK/ERK and PI3K/AKT pathways significantly reduced 
      the migration of OPCs. Based on these findings, it was concluded that CXCL12 may 
      induce the migration of OPCs through the CXCR4‑activated MEK/ERK and PI3K/AKT 
      pathways. The results of the present study support the manipulation of 
      CXCL12‑mediated OPC migration to improve remyelination.
FAU - Tian, Yongyang
AU  - Tian Y
AD  - Department of Orthopedics, Third Military Medical University (Army Medical 
      University), Chongqing 400037, P.R. China.
FAU - Yin, Hong
AU  - Yin H
AD  - Department of Orthopedics, Third Military Medical University (Army Medical 
      University), Chongqing 400037, P.R. China.
FAU - Deng, Xi
AU  - Deng X
AD  - Department of Ultrasound, Xinqiao Hospital, Third Military Medical University 
      (Army Medical University), Chongqing 400037, P.R. China.
FAU - Tang, Beichuan
AU  - Tang B
AD  - Department of Orthopedics, Third Military Medical University (Army Medical 
      University), Chongqing 400037, P.R. China.
FAU - Ren, Xianjun
AU  - Ren X
AD  - Department of Orthopedics, Third Military Medical University (Army Medical 
      University), Chongqing 400037, P.R. China.
FAU - Jiang, Tao
AU  - Jiang T
AD  - Department of Orthopedics, Third Military Medical University (Army Medical 
      University), Chongqing 400037, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20180903
PL  - Greece
TA  - Mol Med Rep
JT  - Molecular medicine reports
JID - 101475259
RN  - 0 (CXCL12 protein, rat)
RN  - 0 (Chemokine CXCL12)
RN  - 0 (Cxcr4 protein, rat)
RN  - 0 (Receptors, CXCR4)
RN  - EC 2.7.1.- (Phosphatidylinositol 3-Kinases)
RN  - EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
RN  - EC 2.7.12.2 (MAP Kinase Kinase 1)
SB  - IM
MH  - Animals
MH  - Cell Movement/genetics
MH  - Chemokine CXCL12/*genetics
MH  - Demyelinating Diseases/genetics/pathology
MH  - Humans
MH  - Inflammation/genetics/pathology
MH  - MAP Kinase Kinase 1/genetics
MH  - Myelin Sheath/genetics/pathology
MH  - Nervous System Diseases/*genetics/metabolism/pathology
MH  - Oligodendrocyte Precursor Cells/metabolism
MH  - Phosphatidylinositol 3-Kinases/genetics
MH  - Proto-Oncogene Proteins c-akt/genetics
MH  - Rats
MH  - Receptors, CXCR4/*genetics
MH  - Remyelination/*genetics
PMC - PMC6172403
EDAT- 2018/09/18 06:00
MHDA- 2019/01/27 06:00
PMCR- 2018/09/03
CRDT- 2018/09/18 06:00
PHST- 2018/02/06 00:00 [received]
PHST- 2018/07/09 00:00 [accepted]
PHST- 2018/09/18 06:00 [pubmed]
PHST- 2019/01/27 06:00 [medline]
PHST- 2018/09/18 06:00 [entrez]
PHST- 2018/09/03 00:00 [pmc-release]
AID - mmr-18-05-4374 [pii]
AID - 10.3892/mmr.2018.9444 [doi]
PST - ppublish
SO  - Mol Med Rep. 2018 Nov;18(5):4374-4380. doi: 10.3892/mmr.2018.9444. Epub 2018 Sep 
      3.