PMID- 30221977
OWN - NLM
STAT- MEDLINE
DCOM- 20210805
LR  - 20231112
IS  - 1947-6043 (Electronic)
IS  - 1947-6035 (Print)
IS  - 1947-6035 (Linking)
VI  - 11
IP  - 4
DP  - 2020 Oct
TI  - Minimal Clinically Important Differences and Substantial Clinical Benefit in 
      Patient-Reported Outcome Measures after Autologous Chondrocyte Implantation.
PG  - 412-422
LID - 10.1177/1947603518799839 [doi]
AB  - OBJECTIVE: We sought to determine the minimal clinically important difference 
      (MCID) and substantial clinical benefit (SCB) associated with the Knee Injury and 
      Osteoarthritis Outcome Score (KOOS), International Knee Documentation Committee 
      (IKDC) Subjective Knee Evaluation Form, Lysholm, and Short Form-12 (SF-12) after 
      autologous chondrocyte implantation (ACI). DESIGN: Ninety-two patients with 
      satisfaction surveys at a minimum of 2 years postoperatively and at least 1 
      repeated patient-reported outcome measure (PROM) were analysed. The MCID was 
      determined using 4 anchor-based methods: average change, mean change, minimally 
      detectable change, and the optimal cutoff point for receiver operating 
      characteristic (ROC) curves. If an anchor-based method was not applicable, 
      standard deviation-based and effect size-based estimates were used. SCB was 
      determined using ROC curve analysis. RESULTS: The 4 anchor-based methods provided 
      a range of MCID values for each PROM (11-18.8 for the KOOS pain, 9.2-17.3 for the 
      KOOS activities of daily living, 12.5-18.6 for the KOOS sport/recreation, 
      12.8-19.6 for the KOOS quality of life, 10.8-16.4 for the IKDC, and 6.2-8.2 for 
      the SF-12 physical component summary). Using the 2 distribution-based methods, 
      the following MCID value ranges were obtained: KOOS symptom, 3.6 to 8.4; the 
      Lysholm, 4.2 to 10.5; and the SF-12 mental component summary, 1.9 to 4.6. SCB was 
      30 for the KOOS sport/recreation and 34.4 for the IKDC, which most accurately 
      predict substantial improvement. No significant association was noted between SCB 
      achievement and the baseline PROMs. CONCLUSION: The MCID and SCB determined in 
      our study will allow interpretation of the effects of treatment in clinical 
      practice and trials. Given the varied MCID values in this study, standardisation 
      of the most appropriate calculation methods is warranted.
FAU - Ogura, Takahiro
AU  - Ogura T
AD  - Sports Medicine Center Funabashi Orthopaedic Hospital, Funabashi, Chiba, Japan.
AD  - Cartilage Repair Center, Brigham and Women's Hospital, Harvard Medical School, 
      Boston, MA, USA.
FAU - Ackermann, Jakob
AU  - Ackermann J
AUID- ORCID: 0000-0002-4063-5815
AD  - Department of Orthopedic Surgery, Massachusetts General Hospital, Harvard Medical 
      School, Boston, MA, USA.
FAU - Barbieri Mestriner, Alexandre
AU  - Barbieri Mestriner A
AD  - Cartilage Repair Center, Brigham and Women's Hospital, Harvard Medical School, 
      Boston, MA, USA.
AD  - Universidade Federal de Sao Paulo, Sao Paulo, Brazil.
FAU - Merkely, Gergo
AU  - Merkely G
AD  - Cartilage Repair Center, Brigham and Women's Hospital, Harvard Medical School, 
      Boston, MA, USA.
AD  - Department of Traumatology, Semmelweis University, Budapest, Hungary.
FAU - Gomoll, Andreas H
AU  - Gomoll AH
AD  - Hospital for Special Surgery, New York, NY, USA.
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
DEP - 20180915
PL  - United States
TA  - Cartilage
JT  - Cartilage
JID - 101518378
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Cartilage Diseases/*surgery
MH  - Chondrocytes/*transplantation
MH  - Female
MH  - Humans
MH  - Knee/*surgery
MH  - Male
MH  - Middle Aged
MH  - *Minimal Clinically Important Difference
MH  - *Patient Reported Outcome Measures
MH  - ROC Curve
MH  - Registries
MH  - Transplantation, Autologous
MH  - Treatment Outcome
MH  - Young Adult
PMC - PMC7488950
OTO - NOTNLM
OT  - International Knee Documentation Committee Subjective Knee Evaluation Form
OT  - Knee Injury and Osteoarthritis Outcome Score
OT  - Lysholm scale
OT  - Short Form-12
OT  - autologous chondrocyte implantation
OT  - cartilage repair
OT  - minimal clinically important difference
OT  - substantial clinical benefit
COIS- Declaration of Conflicting Interests: The author(s) declared no potential 
      conflicts of interest with respect to the research, authorship, and/or 
      publication of this article.
EDAT- 2018/09/18 06:00
MHDA- 2021/08/06 06:00
PMCR- 2021/04/01
CRDT- 2018/09/18 06:00
PHST- 2018/09/18 06:00 [pubmed]
PHST- 2021/08/06 06:00 [medline]
PHST- 2018/09/18 06:00 [entrez]
PHST- 2021/04/01 00:00 [pmc-release]
AID - 10.1177_1947603518799839 [pii]
AID - 10.1177/1947603518799839 [doi]
PST - ppublish
SO  - Cartilage. 2020 Oct;11(4):412-422. doi: 10.1177/1947603518799839. Epub 2018 Sep 
      15.