PMID- 30223113
OWN - NLM
STAT- MEDLINE
DCOM- 20191016
LR  - 20231213
IS  - 1534-4436 (Electronic)
IS  - 1081-1206 (Linking)
VI  - 122
IP  - 1
DP  - 2019 Jan
TI  - Atopic dermatitis in African American patients is T(H)2/T(H)22-skewed with 
      T(H)1/T(H)17 attenuation.
PG  - 99-110.e6
LID - S1081-1206(18)30746-4 [pii]
LID - 10.1016/j.anai.2018.08.024 [doi]
AB  - BACKGROUND: African Americans (AA) are disproportionately impacted by atopic 
      dermatitis (AD), with increased prevalence and therapeutic challenges unique to 
      this population. Molecular profiling data informing development of targeted 
      therapeutics for AD are derived primarily from European American (EA) patients. 
      These studies are absent in AA, hindering development of effective treatments for 
      this population. OBJECTIVE: We sought to characterize the global molecular 
      profile of AD in the skin of AA patients as compared with that of EA AD and 
      healthy controls. METHODS: We performed RNA-Seq with reverse transcription 
      polymerase chain reaction validation and immunohistochemistry studies in lesional 
      and nonlesional skin of AA and EA AD patients vs healthy controls. RESULTS: 
      African American AD lesions were characterized by greater infiltration of 
      dendritic cells (DCs) marked by the high-affinity immunoglobulin E (IgE) receptor 
      (FcepsilonR1+) compared with EA AD (P < .05). Both AD cohorts showed similarly robust 
      up-regulation of Th2-related (CCL17/18/26) and Th22-related markers (interleukin 
      [IL]-22, S100A8/9/12), but AA AD featured decreased expression of innate immune 
      (tumor necrosis factor [TNF], IL-1beta), Th1-related (interferon gamma [IFN-gamma], MX1, 
      IL-12RB1), and Th17-related markers (IL-23p19, IL-36G, CXCL1) vs EA AD (P < .05). 
      The Th2 (IL-13) and Th22-related products (IL-22, S100A8/9/12) and serum IgE were 
      significantly correlated with clinical severity (Scoring of Atopic Dermatitis 
      [SCORAD]) in AA. Fillagrin (FLG) was exclusively down-regulated in EA AD, whereas 
      loricrin (LOR) was down-regulated in both AD cohorts and negatively correlated 
      with SCORAD in AA. CONCLUSION: The molecular phenotype of AA AD skin is 
      characterized by attenuated Th1 and Th17 but similar Th2/Th22-skewing to EA AD. 
      Our data encourages a personalized medicine approach accounting for 
      phenotype-specific characteristics in future development of targeted therapeutics 
      and clinical trial design for AD.
CI  - Copyright (c) 2018 Elsevier Ltd. All rights reserved.
FAU - Sanyal, Riana D
AU  - Sanyal RD
AD  - Laboratory of Inflammatory Skin Diseases, Department of Dermatology, Icahn School 
      of Medicine at Mount Sinai, New York, New York.
FAU - Pavel, Ana B
AU  - Pavel AB
AD  - Laboratory of Inflammatory Skin Diseases, Department of Dermatology, Icahn School 
      of Medicine at Mount Sinai, New York, New York.
FAU - Glickman, Jacob
AU  - Glickman J
AD  - Laboratory of Inflammatory Skin Diseases, Department of Dermatology, Icahn School 
      of Medicine at Mount Sinai, New York, New York.
FAU - Chan, Tom C
AU  - Chan TC
AD  - Laboratory of Inflammatory Skin Diseases, Department of Dermatology, Icahn School 
      of Medicine at Mount Sinai, New York, New York; Department of Dermatology, 
      National Taiwan University Hospital and College of Medicine, Taipei, Taiwan; The 
      Laboratory for Investigative Dermatology, The Rockefeller University, New York, 
      New York.
FAU - Zheng, Xiuzhong
AU  - Zheng X
AD  - The Laboratory for Investigative Dermatology, The Rockefeller University, New 
      York, New York.
FAU - Zhang, Ning
AU  - Zhang N
AD  - Laboratory of Inflammatory Skin Diseases, Department of Dermatology, Icahn School 
      of Medicine at Mount Sinai, New York, New York.
FAU - Cueto, Inna
AU  - Cueto I
AD  - The Laboratory for Investigative Dermatology, The Rockefeller University, New 
      York, New York.
FAU - Peng, Xiangyu
AU  - Peng X
AD  - Laboratory of Inflammatory Skin Diseases, Department of Dermatology, Icahn School 
      of Medicine at Mount Sinai, New York, New York.
FAU - Estrada, Yeriel
AU  - Estrada Y
AD  - Laboratory of Inflammatory Skin Diseases, Department of Dermatology, Icahn School 
      of Medicine at Mount Sinai, New York, New York.
FAU - Fuentes-Duculan, Judilyn
AU  - Fuentes-Duculan J
AD  - The Laboratory for Investigative Dermatology, The Rockefeller University, New 
      York, New York.
FAU - Alexis, Andrew F
AU  - Alexis AF
AD  - Department of Dermatology, Mount Sinai St. Luke's and Mount Sinai West, New York, 
      New York.
FAU - Krueger, James G
AU  - Krueger JG
AD  - The Laboratory for Investigative Dermatology, The Rockefeller University, New 
      York, New York.
FAU - Guttman-Yassky, Emma
AU  - Guttman-Yassky E
AD  - Laboratory of Inflammatory Skin Diseases, Department of Dermatology, Icahn School 
      of Medicine at Mount Sinai, New York, New York. Electronic address: 
      Emma.Guttman@mountsinai.org.
LA  - eng
GR  - TL1 TR001434/TR/NCATS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20180914
PL  - United States
TA  - Ann Allergy Asthma Immunol
JT  - Annals of allergy, asthma & immunology : official publication of the American 
      College of Allergy, Asthma, & Immunology
JID - 9503580
RN  - 0 (CCL17 protein, human)
RN  - 0 (Chemokine CCL17)
RN  - 0 (Cytokines)
RN  - 0 (FLG protein, human)
RN  - 0 (FcepsilonRI alpha-chain, human)
RN  - 0 (Filaggrin Proteins)
RN  - 0 (Interleukins)
RN  - 0 (Receptors, IgE)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adult
MH  - Black or African American/*statistics & numerical data
MH  - Aged
MH  - Base Sequence
MH  - Chemokine CCL17/blood
MH  - Cytokines/*blood
MH  - Dendritic Cells/*immunology
MH  - Dermatitis, Atopic/*immunology
MH  - Female
MH  - Filaggrin Proteins
MH  - Humans
MH  - Immunoglobulin E/*blood/immunology
MH  - Interleukins/immunology
MH  - Male
MH  - Middle Aged
MH  - Receptors, IgE/*immunology
MH  - Sequence Analysis, RNA
MH  - Th1 Cells/immunology
MH  - Th17 Cells/immunology
MH  - Th2 Cells/immunology
MH  - Young Adult
MH  - Interleukin-22
EDAT- 2018/09/18 06:00
MHDA- 2019/10/17 06:00
CRDT- 2018/09/18 06:00
PHST- 2018/08/11 00:00 [received]
PHST- 2018/08/28 00:00 [revised]
PHST- 2018/08/31 00:00 [accepted]
PHST- 2018/09/18 06:00 [pubmed]
PHST- 2019/10/17 06:00 [medline]
PHST- 2018/09/18 06:00 [entrez]
AID - S1081-1206(18)30746-4 [pii]
AID - 10.1016/j.anai.2018.08.024 [doi]
PST - ppublish
SO  - Ann Allergy Asthma Immunol. 2019 Jan;122(1):99-110.e6. doi: 
      10.1016/j.anai.2018.08.024. Epub 2018 Sep 14.