PMID- 30223485
OWN - NLM
STAT- MEDLINE
DCOM- 20181224
LR  - 20211204
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 19
IP  - 9
DP  - 2018 Sep 14
TI  - Mackerel-Derived Fermented Fish Oil Promotes Hair Growth by Anagen-Stimulating 
      Pathways.
LID - 10.3390/ijms19092770 [doi]
LID - 2770
AB  - Hair growth is regulated by the interaction between dermal papilla cells (DPC) 
      and other cells inside the hair follicle. Here, we show the effect and action 
      mechanism of mackerel-derived fermented fish oil (FFO) extract and its component 
      docosahexaenoic acid (DHA) in the control of hair growth. The hair growth effect 
      of FFO extract was evaluated by the culture method of vibrissa follicles and in 
      vivo dotmatrix planimetry method. FFO extract increased the length of hair-fibers 
      and enabled stimulated initiation into the anagen phase of the hair cycle. As 
      expected, FFO extract significantly increased DPC proliferation. FFO extract 
      induced the progression of the cell cycle and the activation of extracellular 
      signal-regulated kinase (ERK), p38 and Akt. FFO extract induced nuclear 
      translocation of beta-catenin, a stimulator of anagen phase, through an increase of 
      phospho-glycogen synthase kinase3beta (GSK3beta) level. Since various prostaglandins 
      are known to promote hair growth in humans and mice, we examined the effect of 
      DHA, a main omega-3 fatty acid of FFO, on DPC proliferation. DHA not only 
      increased DPC proliferation but also upregulated levels of cell cycle-associated 
      proteins such as cyclin D1 and cdc2 p34. These results show that FFO extract and 
      DHA promote hair growth through the anagen-activating pathways in DPC.
FAU - Kang, Jung-Il
AU  - Kang JI
AD  - Department of Medicine, School of Medicine, Jeju National University, 102 
      Jejudaehakno, Jeju 63243, Korea. jikang0024@jejunu.ac.kr.
FAU - Yoon, Hoon-Seok
AU  - Yoon HS
AD  - Department of Medicine, School of Medicine, Jeju National University, 102 
      Jejudaehakno, Jeju 63243, Korea. hsyoon717@jejunu.ac.kr.
FAU - Kim, Sung Min
AU  - Kim SM
AD  - Department of Medicine, School of Medicine, Jeju National University, 102 
      Jejudaehakno, Jeju 63243, Korea. seongmin85@naver.com.
FAU - Park, Jeong Eon
AU  - Park JE
AD  - Department of Medicine, School of Medicine, Jeju National University, 102 
      Jejudaehakno, Jeju 63243, Korea. jeongeon7780@hanmail.net.
FAU - Hyun, Yu Jae
AU  - Hyun YJ
AD  - Department of Medicine, School of Medicine, Jeju National University, 102 
      Jejudaehakno, Jeju 63243, Korea. yujae1113@jejunu.ac.kr.
FAU - Ko, Ara
AU  - Ko A
AD  - Department of Medicine, School of Medicine, Jeju National University, 102 
      Jejudaehakno, Jeju 63243, Korea. rhdkfk0123@naver.com.
FAU - Ahn, Yong-Seok
AU  - Ahn YS
AD  - Choung Ryong Fisheries Co. Ltd., 7825 Iljudong-ro, Namwon-epu, Seogwipo, Jeju 
      63612, Korea. ecoil@hanmail.net.
FAU - Koh, Young Sang
AU  - Koh YS
AD  - Department of Medicine, School of Medicine, Jeju National University, 102 
      Jejudaehakno, Jeju 63243, Korea. yskoh7@jejunu.ac.kr.
AD  - Jeju Research Center for Natural Medicine, Jeju National University, 102 
      Jejudaehakno, Jeju 63243, Korea. yskoh7@jejunu.ac.kr.
FAU - Hyun, Jin Won
AU  - Hyun JW
AD  - Department of Medicine, School of Medicine, Jeju National University, 102 
      Jejudaehakno, Jeju 63243, Korea. jinwonh@jejunu.ac.kr.
AD  - Jeju Research Center for Natural Medicine, Jeju National University, 102 
      Jejudaehakno, Jeju 63243, Korea. jinwonh@jejunu.ac.kr.
FAU - Yoo, Eun-Sook
AU  - Yoo ES
AD  - Department of Medicine, School of Medicine, Jeju National University, 102 
      Jejudaehakno, Jeju 63243, Korea. eunsyoo@jejunu.ac.kr.
AD  - Jeju Research Center for Natural Medicine, Jeju National University, 102 
      Jejudaehakno, Jeju 63243, Korea. eunsyoo@jejunu.ac.kr.
FAU - Kang, Hee-Kyoung
AU  - Kang HK
AD  - Department of Medicine, School of Medicine, Jeju National University, 102 
      Jejudaehakno, Jeju 63243, Korea. pharmkhk@jejunu.ac.kr.
AD  - Jeju Research Center for Natural Medicine, Jeju National University, 102 
      Jejudaehakno, Jeju 63243, Korea. pharmkhk@jejunu.ac.kr.
LA  - eng
PT  - Journal Article
DEP - 20180914
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Fish Oils)
RN  - EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
SB  - IM
MH  - Animals
MH  - Cell Cycle/drug effects
MH  - Cell Proliferation/drug effects
MH  - *Fermented Foods/analysis
MH  - Fish Oils/chemistry/*pharmacology
MH  - Hair/*growth & development
MH  - Hair Follicle/*drug effects/*metabolism
MH  - *Perciformes
MH  - Proto-Oncogene Proteins c-akt/metabolism
MH  - Rats
MH  - Wnt Signaling Pathway
PMC - PMC6164340
OTO - NOTNLM
OT  - Akt
OT  - anagen
OT  - cell cycle progression
OT  - dermal papilla cells
OT  - docosahexaenoic acid
OT  - extracellular signal-regulated kinase
OT  - hair growth
OT  - mackerel-derived fermented fish oil
OT  - p38
OT  - beta-catenin
COIS- The authors declare no conflict of interest.
EDAT- 2018/09/19 06:00
MHDA- 2018/12/26 06:00
PMCR- 2018/09/01
CRDT- 2018/09/19 06:00
PHST- 2018/08/24 00:00 [received]
PHST- 2018/09/07 00:00 [revised]
PHST- 2018/09/10 00:00 [accepted]
PHST- 2018/09/19 06:00 [entrez]
PHST- 2018/09/19 06:00 [pubmed]
PHST- 2018/12/26 06:00 [medline]
PHST- 2018/09/01 00:00 [pmc-release]
AID - ijms19092770 [pii]
AID - ijms-19-02770 [pii]
AID - 10.3390/ijms19092770 [doi]
PST - epublish
SO  - Int J Mol Sci. 2018 Sep 14;19(9):2770. doi: 10.3390/ijms19092770.