PMID- 30223656
OWN - NLM
STAT- MEDLINE
DCOM- 20190520
LR  - 20190520
IS  - 0042-773X (Print)
IS  - 0042-773X (Linking)
VI  - 64
IP  - 6
DP  - 2018 Summer
TI  - Therapy for peptic ulcer disease.
PG  - 595-599
AB  - The modern therapy for peptic ulcer disease and other acid peptic diseases is 
      based on administration of proton pump inhibitors (PPI) which have fully replaced 
      anacids, parasympatholytics and histamine H2 receptor antagonists. The most 
      effective way is to administer proton pump inhibitors in the morning on an empty 
      stomach in a single daily dose. It is a very safe therapy, despite the fact that 
      a potential adverse effect of long-term PPI treatment on the efficacy of other 
      medications (clopidogrel), on bone metabolism and development of respiratory 
      infections have been discussed recently. PPI also play an essential role in the 
      eradication treatment of Helicobacter pylori infection, the prevention and 
      treatment of gastropathy induced by nonsteroidal anti-inflammatory drugs and in 
      relation to some rare hypersecretory conditions. The role of proton pump 
      inhibitors in the therapy for functional dyspepsia is contradictory. Massive 
      bleeding from the peptic ulcer is a relatively frequent complication of NSAID 
      gastropathy. Endoscopic hemostasis and parenteral administration of PPI for at 
      least 72 hours are used in therapy. Key words: acid peptic diseases - gastric 
      secretion - peptic ulcer - proton pump inhibitors.
FAU - Lukas, Milan
AU  - Lukas M
LA  - eng
PT  - Journal Article
TT  - Terapie peptickeho vredu.
PL  - Czech Republic
TA  - Vnitr Lek
JT  - Vnitrni lekarstvi
JID - 0413602
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 0 (Histamine H2 Antagonists)
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Anti-Inflammatory Agents, Non-Steroidal/therapeutic use
MH  - *Helicobacter Infections/complications/drug therapy
MH  - *Helicobacter pylori
MH  - Histamine H2 Antagonists/therapeutic use
MH  - Humans
MH  - *Peptic Ulcer/drug therapy/microbiology
MH  - Proton Pump Inhibitors/therapeutic use
EDAT- 2018/09/19 06:00
MHDA- 2019/05/21 06:00
CRDT- 2018/09/19 06:00
PHST- 2018/09/19 06:00 [entrez]
PHST- 2018/09/19 06:00 [pubmed]
PHST- 2019/05/21 06:00 [medline]
AID - 105520 [pii]
PST - ppublish
SO  - Vnitr Lek. 2018 Summer;64(6):595-599.