PMID- 30223673
OWN - NLM
STAT- MEDLINE
DCOM- 20190506
LR  - 20190506
IS  - 1552-4175 (Electronic)
IS  - 1099-8004 (Linking)
VI  - 21
IP  - 1
DP  - 2019 Jan
TI  - A Systematic Review of Genetic Influence on Psychological Resilience.
PG  - 61-71
LID - 10.1177/1099800418800396 [doi]
AB  - When exposed to adversity, some individuals are at an increased risk of 
      posttraumatic stress disorder, experiencing persistent biopsychosocial 
      disturbances, whereas others adapt well, described as resilience. Resilience is a 
      complex biopsychosocial phenomenon conceptualized as adaptation to adversity 
      influenced by an individual's genetic variants, epistasis, epigenetics, and 
      gene-by-environment interactions. Studies on psychological resilience have 
      focused on behavioral and psychosocial variables with far less examination of the 
      genetic contributions. The purpose of this review is to identify specific genetic 
      variants contributing to the biological capacity for psychological resilience. 
      PubMed and PsycINFO were searched using the following key words: psychological 
      resilience AND genotype(s). Additional articles were identified from the Human 
      Genome Epidemiology Navigator using the term resilience, psychological. Ten 
      studies met the criteria. Six genes were empirically associated with 
      psychological resilience: serotonin-transporter-linked polymorphic region ( 
      5-HTTLPR), dopamine receptor D4, brain-derived neurotrophic factor ( BDNF), 
      corticotropin-releasing hormone receptor 1, oxytocin receptor and regulator of 
      G-protein signaling 2 . The findings of this systematic review suggest that the 
      L/L or L'/L' genotype of 5-HTTLPR and rs25531 in children/adolescents and the S/S 
      or S'/S' genotype in adults are most frequently related to resilience. 
      Additionally, the Val/Val genotype of rs6265 in BDNF in Caucasians was also 
      associated with resilience. There are numerous factors contributing to the 
      complexity of determining the genetic influence on resilience including analysis 
      of rs25531, assumptions of the mode of inheritance, operationalization of 
      resilience, demographic and population characteristics, sample size, and other 
      types of genetic influence including epistasis and epigenetics. While current 
      evidence is supportive, further investigation of the genetic influence on 
      resilience is required.
FAU - Niitsu, Kosuke
AU  - Niitsu K
AUID- ORCID: 0000-0001-5383-7523
AD  - 1 College of Nursing, University of Colorado Anschutz Medical Campus, Aurora, CO, 
      USA.
FAU - Rice, Michael J
AU  - Rice MJ
AD  - 1 College of Nursing, University of Colorado Anschutz Medical Campus, Aurora, CO, 
      USA.
FAU - Houfek, Julia F
AU  - Houfek JF
AD  - 2 College of Nursing, University of Nebraska Medical Center, Omaha, NE, USA.
FAU - Stoltenberg, Scott F
AU  - Stoltenberg SF
AD  - 3 Department of Psychology, University of Nebraska-Lincoln, Lincoln, NE, USA.
FAU - Kupzyk, Kevin A
AU  - Kupzyk KA
AD  - 2 College of Nursing, University of Nebraska Medical Center, Omaha, NE, USA.
FAU - Barron, Cecilia R
AU  - Barron CR
AD  - 2 College of Nursing, University of Nebraska Medical Center, Omaha, NE, USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Systematic Review
DEP - 20180917
PL  - United States
TA  - Biol Res Nurs
JT  - Biological research for nursing
JID - 9815758
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Receptors, Corticotropin-Releasing Hormone)
RN  - 0 (Serotonin Plasma Membrane Transport Proteins)
RN  - 137750-34-6 (Receptors, Dopamine D4)
SB  - IM
MH  - *Adaptation, Psychological
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Female
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Genetic
MH  - Receptors, Corticotropin-Releasing Hormone/*genetics
MH  - Receptors, Dopamine D4/*genetics
MH  - *Resilience, Psychological
MH  - Serotonin Plasma Membrane Transport Proteins/*genetics
MH  - Stress, Psychological/*genetics
OTO - NOTNLM
OT  - adversity
OT  - gene-by-environment interaction
OT  - genetics
OT  - genotype
OT  - psychological resilience
OT  - systematic review
EDAT- 2018/09/19 06:00
MHDA- 2019/05/07 06:00
CRDT- 2018/09/19 06:00
PHST- 2018/09/19 06:00 [pubmed]
PHST- 2019/05/07 06:00 [medline]
PHST- 2018/09/19 06:00 [entrez]
AID - 10.1177/1099800418800396 [doi]
PST - ppublish
SO  - Biol Res Nurs. 2019 Jan;21(1):61-71. doi: 10.1177/1099800418800396. Epub 2018 Sep 
      17.