PMID- 30224622
OWN - NLM
STAT- MEDLINE
DCOM- 20190318
LR  - 20190318
IS  - 0387-821X (Print)
IS  - 0387-821X (Linking)
VI  - 40
IP  - 3
DP  - 2018
TI  - [Evaluation of Clinical Features and Growth Hormone Deficiency in Short Children 
      Born Small For Gestational Age].
PG  - 253-257
LID - 10.7888/juoeh.40.253 [doi]
AB  - Growth hormone (GH) therapy for short children born small for gestational age 
      (SGA) has been approved in Japan. It is important to evaluate GH secretion 
      ability before the initiation of GH therapy because there are some differences in 
      dose and medical expenses between short children born SGA and GH deficiency 
      (GHD). This study was designed to elucidate the incidence of GHD and to find a 
      useful marker for detecting it in short SGA children. We retrospectively reviewed 
      medical records to analyze the clinical features of short children born SGA and 
      with GHD who had started GH therapy before the age of 6 in the University 
      Hospital of Occupational and Environmental Health and Kyushu Rousai Hospital. 
      Nine of 22 SGA subjects (41%) had GHD. There were no significant differences 
      between two groups of short SGA children (GHD, non-GHD) in the median of height 
      and serum insulin-like growth factors (IGF)-1 levels at birth or at the start of 
      GH therapy. The probability of GHD was higher if the height standard deviation 
      scores (SD) of the SGA children were lower than -3.2 (odds ratio, 11.6; 95% 
      confidence interval, 1.52 - 89.1, P = 0.013). This study showed that there is an 
      approximately 40% incidence of GHD in short SGA children needing GH treatment. We 
      should do GH stimulation tests for short SGA children whose height SD is lower 
      than -3 to determine the appropriate GH therapy.
FAU - Ikegami, Tomomi
AU  - Ikegami T
AD  - Department of Pediatrics, School of Medicine, University of Occupational and 
      Environmental Health, Japan.
FAU - Araki, Shunsuke
AU  - Araki S
AD  - Department of Pediatrics, School of Medicine, University of Occupational and 
      Environmental Health, Japan.
FAU - Kuwamura, Mami
AU  - Kuwamura M
AD  - Department of Pediatrics, School of Medicine, University of Occupational and 
      Environmental Health, Japan.
FAU - Taku, Aoi
AU  - Taku A
AD  - Department of Pediatrics, School of Medicine, University of Occupational and 
      Environmental Health, Japan.
FAU - Saito, Reiko
AU  - Saito R
AD  - Department of Pediatrics, School of Medicine, University of Occupational and 
      Environmental Health, Japan.
FAU - Goto, Motohide
AU  - Goto M
AD  - Department of Pediatrics, School of Medicine, University of Occupational and 
      Environmental Health, Japan.
FAU - Kubo, Kazuyasu
AU  - Kubo K
AD  - Department of Pediatrics, School of Medicine, University of Occupational and 
      Environmental Health, Japan.
FAU - Kawagoe, Rinko
AU  - Kawagoe R
AD  - Department of Pediatrics, Tobata General Hospital , Japan.
FAU - Yamamoto, Yukiyo
AU  - Yamamoto Y
AD  - Department of Pediatrics, School of Medicine, University of Occupational and 
      Environmental Health, Japan.
FAU - Kawada, Yasusada
AU  - Kawada Y
AD  - Department of Pediatrics, Kyushu Rosai Hospital , Japan.
FAU - Kusuhara, Koichi
AU  - Kusuhara K
AD  - Department of Pediatrics, School of Medicine, University of Occupational and 
      Environmental Health, Japan.
LA  - jpn
PT  - Journal Article
PL  - Japan
TA  - J UOEH
JT  - Journal of UOEH
JID - 7909645
RN  - 12629-01-5 (Human Growth Hormone)
SB  - IM
MH  - Birth Weight
MH  - Body Height
MH  - Child
MH  - Human Growth Hormone/*deficiency
MH  - Humans
MH  - Infant, Newborn
MH  - Infant, Small for Gestational Age
OTO - NOTNLM
OT  - growth hormone
OT  - insulin-like growth factors
OT  - short stature
EDAT- 2018/09/19 06:00
MHDA- 2019/03/19 06:00
CRDT- 2018/09/19 06:00
PHST- 2018/09/19 06:00 [entrez]
PHST- 2018/09/19 06:00 [pubmed]
PHST- 2019/03/19 06:00 [medline]
AID - 10.7888/juoeh.40.253 [doi]
PST - ppublish
SO  - J UOEH. 2018;40(3):253-257. doi: 10.7888/juoeh.40.253.