PMID- 30225831
OWN - NLM
STAT- MEDLINE
DCOM- 20181120
LR  - 20181120
IS  - 1573-904X (Electronic)
IS  - 0724-8741 (Linking)
VI  - 35
IP  - 11
DP  - 2018 Sep 17
TI  - Genetic Basis of Delayed Hypersensitivity Reactions to Drugs in Jewish and Arab 
      Populations.
PG  - 211
LID - 10.1007/s11095-018-2472-8 [doi]
AB  - Genetic variation can affect drug pharmacokinetics and pharmacodynamics and 
      contribute to variability between individuals in response to medications. 
      Specifically, differences in allele frequencies among individuals and ethnic 
      groups have been associated with variation in their propensity to develop drug 
      hypersensitivity reactions (HSRs). This article reviews the current knowledge on 
      the genetic background of HSRs and its relevance to Jewish and Arab populations. 
      The focus is on human leukocyte antigen (HLA) alleles and haplotypes as 
      predictive markers of HSRs ("immunopharmacogenetics"), but other genes and 
      alleles are described as well. Also discussed is the translation of the 
      pharmacogenetic information to practice recommendations.
FAU - Aboukaoud, Mohammed
AU  - Aboukaoud M
AD  - Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew 
      University of Jerusalem, Room 613, Ein Kerem, 91120, Jerusalem, Israel.
FAU - Israel, Shoshana
AU  - Israel S
AD  - Tissue Typing Unit, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
FAU - Brautbar, Chaim
AU  - Brautbar C
AD  - Tissue Typing Unit, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
FAU - Eyal, Sara
AU  - Eyal S
AUID- ORCID: 0000-0003-1275-6094
AD  - Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew 
      University of Jerusalem, Room 613, Ein Kerem, 91120, Jerusalem, Israel. 
      sarae@ekmd.huji.ac.il.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20180917
PL  - United States
TA  - Pharm Res
JT  - Pharmaceutical research
JID - 8406521
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Alleles
MH  - Arabs/genetics
MH  - Drug Discovery
MH  - Gene Frequency
MH  - Genetic Variation
MH  - HLA Antigens/*genetics
MH  - Haplotypes
MH  - Humans
MH  - Hypersensitivity, Delayed/*genetics
MH  - Jews/genetics
OTO - NOTNLM
OT  - Arab
OT  - Jewish
OT  - human leukocyte antigens
OT  - hypersensitivity reactions
EDAT- 2018/09/19 06:00
MHDA- 2018/11/21 06:00
CRDT- 2018/09/19 06:00
PHST- 2018/06/04 00:00 [received]
PHST- 2018/08/01 00:00 [accepted]
PHST- 2018/09/19 06:00 [entrez]
PHST- 2018/09/19 06:00 [pubmed]
PHST- 2018/11/21 06:00 [medline]
AID - 10.1007/s11095-018-2472-8 [pii]
AID - 10.1007/s11095-018-2472-8 [doi]
PST - epublish
SO  - Pharm Res. 2018 Sep 17;35(11):211. doi: 10.1007/s11095-018-2472-8.