PMID- 30226912
OWN - NLM
STAT- MEDLINE
DCOM- 20190207
LR  - 20240327
IS  - 1678-4170 (Electronic)
IS  - 0066-782X (Print)
IS  - 0066-782X (Linking)
VI  - 110
IP  - 6
DP  - 2018 Jun
TI  - Is There any Relationship Between Myocardial Repolarization Parameters and the 
      Frequency of Ventricular Premature Contractions?
PG  - 534-541
LID - S0066-782X2018000600534 [pii]
LID - 10.5935/abc.20180079 [doi]
AB  - BACKGROUND: Ventricular premature contractions (VPCs) may trigger lethal 
      ventricular arrhythmias in patients with structural heart disease. However, this 
      role of VPCs in healthy people remains controversial once that not enough 
      clinical trials are available. Recently, some myocardial repolarization markers, 
      such as Tp-e interval, Tp-e/QT, and Tp-e/QTc ratios, have been reported to be 
      useful for predicting lethal ventricular arrhythmias in various clinical 
      disorders without structural heart disease. OBJECTIVE: In this study, we aimed to 
      investigate the relation between VPC frequent and myocardial repolarization 
      markers in individuals without structural heart disease. METHODS: This study 
      included 100 patients who had complaints of dizziness and palpitations. 
      Twelve-lead electrocardiography and 24-hour ambulatory Holter recordings were 
      obtained from all patients. VPC burden was calculated as the total number of VPCs 
      divided by the number of all QRS complexes in the total recording time. P-values 
      < 0.05 were considered significant. RESULTS: Tp-e interval and Tp-e/QTc ratio 
      were significantly higher in patients with higher VPC burden than in patients 
      with lower VPC burden, and a positive correlation was found between these markers 
      and VPC burden. Tp-e (beta = 1.318, p = 0.043) and Tp-e/QTc (beta = -405.136, p = 
      0.024) in the lead V5 were identified as independent predictors of increased VPC 
      burden. CONCLUSIONS: Tp-e interval and Tp-e/QTc ratio increased in patients with 
      high VPC number. Our study showed that VPCs may have a negative effect on 
      myocardial repolarization. This interaction may lead to an increased risk of 
      malignant arrhythmias.
FAU - Karaman, Kayihan
AU  - Karaman K
AD  - Gaziosmanpasa University Faculty of Medicine, Department of Cardiology, Tokat - 
      Turkey.
FAU - Karayakali, Metin
AU  - Karayakali M
AD  - Gaziosmanpasa University Faculty of Medicine, Department of Cardiology, Tokat - 
      Turkey.
FAU - Arisoy, Arif
AU  - Arisoy A
AD  - Gaziosmanpasa University Faculty of Medicine, Department of Cardiology, Tokat - 
      Turkey.
FAU - Akar, Ilker
AU  - Akar I
AD  - Gaziosmanpasa University Faculty of Medicine, Department of Cardiovascular 
      Surgery, Tokat - Turkey.
FAU - Ozturk, Mustafa
AU  - Ozturk M
AD  - Erzurum Territorial Training and Research Hospital, Cardiology Clinic, Erzurum - 
      Turkey.
FAU - Yanik, Ahmet
AU  - Yanik A
AD  - Samsun Training and Research Hospital, Cardiology Clinic, Samsun - Turkey.
FAU - Yilmaz, Samet
AU  - Yilmaz S
AD  - Gaziosmanpasa University Faculty of Medicine, Department of Cardiology, Tokat - 
      Turkey.
FAU - Celik, Atac
AU  - Celik A
AD  - Gaziosmanpasa University Faculty of Medicine, Department of Cardiology, Tokat - 
      Turkey.
LA  - eng
LA  - por
PT  - Journal Article
PL  - Brazil
TA  - Arq Bras Cardiol
JT  - Arquivos brasileiros de cardiologia
JID - 0421031
SB  - IM
MH  - Adult
MH  - Aged
MH  - Analysis of Variance
MH  - Arrhythmias, Cardiac/physiopathology
MH  - Cross-Sectional Studies
MH  - Echocardiography
MH  - *Electrocardiography, Ambulatory
MH  - Heart/*physiopathology
MH  - Heart Ventricles/physiopathology
MH  - Humans
MH  - Middle Aged
MH  - Prospective Studies
MH  - Regression Analysis
MH  - Statistics, Nonparametric
MH  - Ventricular Premature Complexes/*physiopathology
PMC - PMC6023631
COIS- Potential Conflict of Interest No potential conflict of interest relevant to this 
      article was reported.
EDAT- 2018/09/19 06:00
MHDA- 2019/02/08 06:00
PMCR- 2018/07/01
CRDT- 2018/09/19 06:00
PHST- 2017/06/19 00:00 [received]
PHST- 2017/10/18 00:00 [accepted]
PHST- 2018/09/19 06:00 [entrez]
PHST- 2018/09/19 06:00 [pubmed]
PHST- 2019/02/08 06:00 [medline]
PHST- 2018/07/01 00:00 [pmc-release]
AID - S0066-782X2018000600534 [pii]
AID - 10.5935/abc.20180079 [doi]
PST - ppublish
SO  - Arq Bras Cardiol. 2018 Jun;110(6):534-541. doi: 10.5935/abc.20180079.