PMID- 30227240
OWN - NLM
STAT- MEDLINE
DCOM- 20190114
LR  - 20220409
IS  - 1873-3476 (Electronic)
IS  - 0378-5173 (Linking)
VI  - 551
IP  - 1-2
DP  - 2018 Nov 15
TI  - Inhalation treatment of idiopathic pulmonary fibrosis with curcumin large porous 
      microparticles.
PG  - 212-222
LID - S0378-5173(18)30682-3 [pii]
LID - 10.1016/j.ijpharm.2018.09.031 [doi]
AB  - Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease 
      with high mortality and poor prognosis. Curcumin shows anti-inflammatory effect 
      by suppressing pro-inflammatory cytokines and inhibiting NF-kappaB mediated 
      inflammation. Here, we developed inhalable curcumin-loaded 
      poly(lactic-co-glycolic)acid (PLGA) large porous microparticles (LPMPs) for the 
      treatment of IPF. Curcumin LPMPs were rough and loose particles with many pores 
      on the surfaces and channels in the inner spaces. The mean geometric diameter of 
      them was larger than 10 microm while the aerodynamic diameter was only 3.12 microm due to 
      their porous structures. They showed a fine particle fraction (FPF) <4.46 mum of 
      13.41%, 71% cumulative release after 9 h, and more importantly, they avoided 
      uptake by alveolar macrophages. Therefore, most of released curcumin had 
      opportunities to enter lung tissues. Rat pulmonary fibrosis models were 
      established via once intratracheal administration of bleomycin. Curcumin powders 
      and curcumin LPMPs were administered on Days 2, 7, 14, and 21. Curcumin LPMPs 
      remarkably attenuated lung injuries, decreased hydroxyproline contents, reduced 
      the synthesis of collagen I, and inhibited the expressions of TNF-alpha, TGF-beta1, 
      NF-kappaB p65 and MMP9. Moreover, curcumin LPMPs showed higher antifibrotic activity 
      than curcumin powders. Curcumin LPMPs are a promising inhalable medication for 
      the treatment of IPF.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - Hu, Yuzhen
AU  - Hu Y
AD  - Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, 
      27 Taiping Road, Beijing 100850, China; Anhui Medical University, Hefei 230001, 
      China.
FAU - Li, Miao
AU  - Li M
AD  - Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, 
      27 Taiping Road, Beijing 100850, China.
FAU - Zhang, Mengmeng
AU  - Zhang M
AD  - Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, 
      27 Taiping Road, Beijing 100850, China; Pharmaceutical College of Henan 
      University, Kaifeng 475004, China.
FAU - Jin, Yiguang
AU  - Jin Y
AD  - Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, 
      27 Taiping Road, Beijing 100850, China; Anhui Medical University, Hefei 230001, 
      China. Electronic address: jinyg@sina.com.
LA  - eng
PT  - Journal Article
DEP - 20180915
PL  - Netherlands
TA  - Int J Pharm
JT  - International journal of pharmaceutics
JID - 7804127
RN  - 0 (Collagen Type I)
RN  - 0 (Drug Carriers)
RN  - 0 (Transcription Factor RelA)
RN  - 0 (Transforming Growth Factor beta1)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 1SIA8062RS (Polylactic Acid-Polyglycolic Acid Copolymer)
RN  - EC 3.4.24.35 (Matrix Metalloproteinase 9)
RN  - EC 3.4.24.35 (Mmp9 protein, rat)
RN  - IT942ZTH98 (Curcumin)
RN  - RMB44WO89X (Hydroxyproline)
SB  - IM
MH  - Administration, Inhalation
MH  - Animals
MH  - Collagen Type I/metabolism
MH  - Curcumin/*administration & dosage/chemistry
MH  - Drug Carriers/*administration & dosage
MH  - Hydroxyproline/metabolism
MH  - Idiopathic Pulmonary Fibrosis/*drug therapy/metabolism
MH  - Lung/drug effects/metabolism
MH  - Macrophages, Alveolar/metabolism
MH  - Male
MH  - Matrix Metalloproteinase 9/metabolism
MH  - Microspheres
MH  - Polylactic Acid-Polyglycolic Acid Copolymer/administration & dosage/chemistry
MH  - Porosity
MH  - Rats, Sprague-Dawley
MH  - Transcription Factor RelA/metabolism
MH  - Transforming Growth Factor beta1/metabolism
MH  - Tumor Necrosis Factor-alpha/metabolism
OTO - NOTNLM
OT  - Curcumin
OT  - Curcumin (PubChem ID: 969516)
OT  - Large porous microparticle
OT  - Poly(lactic-co-glycolic)acid
OT  - Pulmonary delivery
OT  - Pulmonary fibrosis
EDAT- 2018/09/19 06:00
MHDA- 2019/01/15 06:00
CRDT- 2018/09/19 06:00
PHST- 2018/02/07 00:00 [received]
PHST- 2018/09/11 00:00 [revised]
PHST- 2018/09/13 00:00 [accepted]
PHST- 2018/09/19 06:00 [pubmed]
PHST- 2019/01/15 06:00 [medline]
PHST- 2018/09/19 06:00 [entrez]
AID - S0378-5173(18)30682-3 [pii]
AID - 10.1016/j.ijpharm.2018.09.031 [doi]
PST - ppublish
SO  - Int J Pharm. 2018 Nov 15;551(1-2):212-222. doi: 10.1016/j.ijpharm.2018.09.031. 
      Epub 2018 Sep 15.