PMID- 30228048 OWN - NLM STAT- MEDLINE DCOM- 20200625 LR - 20221207 IS - 1094-6950 (Print) IS - 1094-6950 (Linking) VI - 22 IP - 2 DP - 2019 Apr-Jun TI - Fibroblast Growth Factor 21 Is Associated With Bone Mineral Density, but not With Bone Turnover Markers and Fractures in Chinese Postmenopausal Women. PG - 179-184 LID - S1094-6950(18)30169-0 [pii] LID - 10.1016/j.jocd.2018.08.005 [doi] AB - Fibroblast growth factor 21 (FGF21) is a member of the endocrine FGF subfamily and an important metabolic regulator that has multiple beneficial effects on glucose homeostasis and lipid metabolism. However, it was unclear whether FGF21 would induce bone defects in humans. This study evaluated the associations of FGF21 levels, bone mineral density (BMD), osteoporotic fracture, and bone turnover marks (BTMs) in postmenopausal women. A total of 1342 postmenopausal Chinese Han women (511 cases of fragility fracture in the case group and 831 cases in nonfragility fracture group) were enrolled. Serum FGF21 concentration was measured by ELISA (Quantikine), serum calcium (Ca), phosphate (P), alkaline phosphatase, 25-hydroxyvitamin D, parathyroid hormone, beta-crosslinked C-telopeptide of type l collagen, were measured using an automated Roche electro-chemiluminescence system. BMD was measured using dual-energy X-ray absorptiometry. The association with age, BMD, 25-hydroxyvitamin D, parathyroid hormone, beta-crosslinked C-telopeptide of type l collagen, and FGF21 levels were also evaluated in postmenopausal women. In nonfracture group and fragility fracture group, postmenopausal women's FGF21 level was 226.57pg/mL (149.11-354.43 pg/mL) and 219.43pg/mL (147.21-323.74 pg/mL), respectively. There is no significant difference in serum FGF21 levels between the fragility fracture group and the nonfracture group (p = 0.160). There was a significant statistical difference in BMD between the fragility fracture group and the nonfracture group (p = 0.000). In multiple linear regression analysis, FGF21 levels were significantly positive associated with lumbar BMD in postmenopausal women (L1-4, p = 0.007), independent of other factors, especially in fragility fracture group (L1-4, p = 0.001). In addition, a significant positive association was also observed between serum FGF21 levels and age in postmenopausal women (p < 0.05). We reveal a positive correlation between serum FGF21 concentrations with lumbar BMD in Chinese Han postmenopausal women. No significant correlations are present between serum FGF21 and bone turnover marks or serum FGF21 and fragility fracture in our study. CI - Copyright (c) 2018 The International Society for Clinical Densitometry. Published by Elsevier Inc. All rights reserved. FAU - Hu, WeiWei AU - Hu W AD - Metabolic Bone Disease and Genetic Research Unit, Department of Osteoporosis and Bone Diseases, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China. FAU - He, Jinwei AU - He J AD - Metabolic Bone Disease and Genetic Research Unit, Department of Osteoporosis and Bone Diseases, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China. FAU - Fu, Wenzhen AU - Fu W AD - Metabolic Bone Disease and Genetic Research Unit, Department of Osteoporosis and Bone Diseases, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China. FAU - Wang, Chun AU - Wang C AD - Metabolic Bone Disease and Genetic Research Unit, Department of Osteoporosis and Bone Diseases, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China. FAU - Yue, Hue AU - Yue H AD - Metabolic Bone Disease and Genetic Research Unit, Department of Osteoporosis and Bone Diseases, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China. FAU - Gu, Jiemei AU - Gu J AD - Metabolic Bone Disease and Genetic Research Unit, Department of Osteoporosis and Bone Diseases, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China. FAU - Zhang, Hao AU - Zhang H AD - Metabolic Bone Disease and Genetic Research Unit, Department of Osteoporosis and Bone Diseases, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China. FAU - Zhang, Zhenlin AU - Zhang Z AD - Metabolic Bone Disease and Genetic Research Unit, Department of Osteoporosis and Bone Diseases, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China. Electronic address: zhangzl@sjtu.edu.cn. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20180822 PL - United States TA - J Clin Densitom JT - Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry JID - 9808212 RN - 0 (Collagen Type I) RN - 0 (FGF21 protein, human) RN - 0 (Parathyroid Hormone) RN - 0 (Peptides) RN - 0 (Phosphates) RN - 0 (collagen type I trimeric cross-linked peptide) RN - 1406-16-2 (Vitamin D) RN - 62031-54-3 (Fibroblast Growth Factors) RN - A288AR3C9H (25-hydroxyvitamin D) RN - EC 3.1.3.1 (Alkaline Phosphatase) RN - SY7Q814VUP (Calcium) SB - IM MH - Absorptiometry, Photon MH - Aged MH - Alkaline Phosphatase/blood MH - *Asian People MH - *Bone Density MH - *Bone Remodeling MH - Calcium/blood MH - Case-Control Studies MH - China MH - Collagen Type I/*blood MH - Female MH - Fibroblast Growth Factors/*blood MH - Humans MH - Linear Models MH - Middle Aged MH - Osteoporosis, Postmenopausal/*blood/diagnostic imaging MH - Osteoporotic Fractures/*blood MH - Parathyroid Hormone/blood MH - Peptides/*blood MH - Phosphates/blood MH - Postmenopause MH - Vitamin D/analogs & derivatives/blood OTO - NOTNLM OT - Fibroblast growth factor 21 OT - bone mineral density OT - fracture OT - osteoporosis OT - postmenopausal women EDAT- 2018/09/20 06:00 MHDA- 2020/06/26 06:00 CRDT- 2018/09/20 06:00 PHST- 2018/07/16 00:00 [received] PHST- 2018/08/13 00:00 [revised] PHST- 2018/08/13 00:00 [accepted] PHST- 2018/09/20 06:00 [pubmed] PHST- 2020/06/26 06:00 [medline] PHST- 2018/09/20 06:00 [entrez] AID - S1094-6950(18)30169-0 [pii] AID - 10.1016/j.jocd.2018.08.005 [doi] PST - ppublish SO - J Clin Densitom. 2019 Apr-Jun;22(2):179-184. doi: 10.1016/j.jocd.2018.08.005. Epub 2018 Aug 22.