PMID- 30228197
OWN - NLM
STAT- MEDLINE
DCOM- 20190212
LR  - 20240213
IS  - 1943-2631 (Electronic)
IS  - 0016-6731 (Print)
IS  - 0016-6731 (Linking)
VI  - 210
IP  - 3
DP  - 2018 Nov
TI  - The mTOR Target S6 Kinase Arrests Development in Caenorhabditis elegans When the 
      Heat-Shock Transcription Factor Is Impaired.
PG  - 999-1009
LID - 10.1534/genetics.118.301533 [doi]
AB  - The widely conserved heat-shock response, regulated by heat-shock transcription 
      factors, is not only essential for cellular stress resistance and adult 
      longevity, but also for proper development. However, the genetic mechanisms by 
      which heat-shock transcription factors regulate development are not well 
      understood. In Caenorhabditis elegans, we conducted an unbiased genetic screen to 
      identify mutations that could ameliorate the developmental-arrest phenotype of a 
      heat-shock factor mutant. Here, we show that loss of the conserved translational 
      activator rsks-1/S6 kinase, a downstream effector of mechanistic Target of 
      Rapamycin (mTOR) kinase, can rescue the developmental-arrest phenotype of hsf-1 
      partial loss-of-function mutants. Unexpectedly, we show that the rescue is not 
      likely caused by reduced translation, nor by activation of any of a variety of 
      stress-protective genes and pathways. Our findings identify an as-yet unexplained 
      regulatory relationship between the heat-shock transcription factor and the mTOR 
      pathway during C. elegans development.
CI  - Copyright (c) 2018 by the Genetics Society of America.
FAU - Chisnell, Peter
AU  - Chisnell P
AUID- ORCID: 0000-0003-4923-6789
AD  - Department of Biochemistry and Biophysics, University of California, San 
      Francisco, California 94158.
AD  - Department of Physiology, University of California, San Francisco, California 
      94158.
FAU - Parenteau, T Richard
AU  - Parenteau TR
AD  - Department of Biochemistry and Biophysics, University of California, San 
      Francisco, California 94158.
FAU - Tank, Elizabeth
AU  - Tank E
AD  - Department of Neurology, University of Michigan, Ann Arbor, Michigan 48109.
FAU - Ashrafi, Kaveh
AU  - Ashrafi K
AD  - Department of Physiology, University of California, San Francisco, California 
      94158.
FAU - Kenyon, Cynthia
AU  - Kenyon C
AD  - Department of Biochemistry and Biophysics, University of California, San 
      Francisco, California 94158 cynthia@calicolabs.com.
LA  - eng
SI  - figshare/10.25386/genetics.7094729
GR  - P40 OD010440/OD/NIH HHS/United States
GR  - R01 AG011816/AG/NIA NIH HHS/United States
GR  - R01 AG046400/AG/NIA NIH HHS/United States
GR  - R37 AG011816/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20180918
PL  - United States
TA  - Genetics
JT  - Genetics
JID - 0374636
RN  - 0 (Caenorhabditis elegans Proteins)
RN  - 0 (Transcription Factors)
RN  - 0 (heat shock factor-1, C elegans)
RN  - EC 2.7.11.1 (Ribosomal Protein S6 Kinases, 70-kDa)
RN  - EC 2.7.11.1 (Rsks-1 protein, C elegans)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Animals
MH  - Caenorhabditis elegans/genetics/*growth & development/*metabolism
MH  - Caenorhabditis elegans Proteins/*genetics/*metabolism
MH  - *Gene Deletion
MH  - Ribosomal Protein S6 Kinases, 70-kDa/deficiency/genetics/*metabolism
MH  - TOR Serine-Threonine Kinases/*metabolism
MH  - Transcription Factors/*genetics/*metabolism
PMC - PMC6218238
OTO - NOTNLM
OT  - C. elegans
OT  - WormBase
OT  - development
OT  - developmental arrest
OT  - heat shock factor
OT  - mTOR
OT  - ribosomal S6 kinase
OT  - translation
EDAT- 2018/09/20 06:00
MHDA- 2019/02/13 06:00
PMCR- 2019/11/01
CRDT- 2018/09/20 06:00
PHST- 2018/04/25 00:00 [received]
PHST- 2018/09/07 00:00 [accepted]
PHST- 2018/09/20 06:00 [pubmed]
PHST- 2019/02/13 06:00 [medline]
PHST- 2018/09/20 06:00 [entrez]
PHST- 2019/11/01 00:00 [pmc-release]
AID - genetics.118.301533 [pii]
AID - 301533 [pii]
AID - 10.1534/genetics.118.301533 [doi]
PST - ppublish
SO  - Genetics. 2018 Nov;210(3):999-1009. doi: 10.1534/genetics.118.301533. Epub 2018 
      Sep 18.