PMID- 30228293 OWN - NLM STAT- MEDLINE DCOM- 20191114 LR - 20191114 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 8 IP - 1 DP - 2018 Sep 18 TI - Isolated hallucination is less predictive than thought disorder in psychosis: Insight from a longitudinal study in a clinical population at high risk for psychosis. PG - 13962 LID - 10.1038/s41598-018-32215-6 [doi] LID - 13962 AB - Perceptual abnormalities (PAs) such as auditory hallucinations are one of the most common symptoms of psychotic patients. However, it remains unclear whether symptoms of sub-clinical PAs also play a key role in predicting psychosis. In an ongoing prospective follow-up study of individuals at a clinical high risk (CHR) of psychosis, we evaluated the potential of first-time experience of PAs and/or thought content disorders (TCDs) to predict psychosis. Conversion to psychosis was the major focus of this follow-up study. A total of 511 CHRs were recruited, of whom 443 (86.7%) completed the clinical follow-up of at least 6 months and up to 2 years. CHRs were divided into four groups according to the presence of PAs and/or TCDs. At the follow-up endpoint, 39 (19.9%) CHRs in the "TCDs-only" group, 2 (8.3%) in the "PAs-only" group, 45 (17.0%) in the "TCDs-and-PAs" group, and 1 (3.8%) in the "None" group converted to psychosis. Survival analysis revealed a higher conversion rate in CHRs with TCDs compared with those with PAs only. CHRs with isolated PAs had shown a higher level of dysphoric mood at baseline compared with those with TCDs. About 89% TCDs contents were related with their experienced PAs. Compared with TCDs, the isolated PAs are not strongly associated with increased susceptibility to psychosis. FAU - Zhang, TianHong AU - Zhang T AD - Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Key Laboratory of Psychotic Disorders, Shanghai, 200030, P. R. China. FAU - Xu, LiHua AU - Xu L AD - Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Key Laboratory of Psychotic Disorders, Shanghai, 200030, P. R. China. FAU - Tang, YingYing AU - Tang Y AD - Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Key Laboratory of Psychotic Disorders, Shanghai, 200030, P. R. China. FAU - Cui, HuiRu AU - Cui H AD - Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Key Laboratory of Psychotic Disorders, Shanghai, 200030, P. R. China. FAU - Wei, YanYan AU - Wei Y AD - Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Key Laboratory of Psychotic Disorders, Shanghai, 200030, P. R. China. FAU - Tang, XiaoChen AU - Tang X AD - Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Key Laboratory of Psychotic Disorders, Shanghai, 200030, P. R. China. FAU - Hu, Qiang AU - Hu Q AD - Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Key Laboratory of Psychotic Disorders, Shanghai, 200030, P. R. China. FAU - Wang, Yan AU - Wang Y AD - Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Key Laboratory of Psychotic Disorders, Shanghai, 200030, P. R. China. FAU - Zhu, YiKang AU - Zhu Y AD - Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Key Laboratory of Psychotic Disorders, Shanghai, 200030, P. R. China. FAU - Jiang, LiJuan AU - Jiang L AD - Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Key Laboratory of Psychotic Disorders, Shanghai, 200030, P. R. China. FAU - Hui, Li AU - Hui L AD - Institute of Mental Health, The Affiliated Guangji Hospital of Soochow Unversity, Soochow Unversity, 215137, Suzhou, P. R. China. FAU - Liu, XiaoHua AU - Liu X AD - Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Key Laboratory of Psychotic Disorders, Shanghai, 200030, P. R. China. drliuxiaohua@gmail.com. FAU - Li, ChunBo AU - Li C AD - Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Key Laboratory of Psychotic Disorders, Shanghai, 200030, P. R. China. AD - CAS Center for Excellence in Brain Science and Intelligence Technology (CEBSIT), Chinese Academy of Science, Shanghai, P. R. China. FAU - Wang, JiJun AU - Wang J AD - Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Key Laboratory of Psychotic Disorders, Shanghai, 200030, P. R. China. jijunwang27@163.com. AD - CAS Center for Excellence in Brain Science and Intelligence Technology (CEBSIT), Chinese Academy of Science, Shanghai, P. R. China. jijunwang27@163.com. AD - Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai, China. jijunwang27@163.com. LA - eng GR - 81671329, 81671332/National Natural Science Foundation of China (National Science Foundation of China)/International GR - 2016YFC1306803/Chinese Ministry of Science and Technology | Department of S and T for Social Development (Department of S&T for Social Development)/International PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20180918 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Adult MH - Female MH - Follow-Up Studies MH - Hallucinations/*physiopathology MH - Humans MH - Longitudinal Studies MH - Male MH - Prospective Studies MH - Psychiatric Status Rating Scales MH - Psychotic Disorders/*diagnosis MH - Risk Factors MH - Survival Rate MH - Thinking/*physiology MH - Young Adult PMC - PMC6143535 COIS- The authors declare no competing interests. EDAT- 2018/09/20 06:00 MHDA- 2019/11/15 06:00 PMCR- 2018/09/18 CRDT- 2018/09/20 06:00 PHST- 2018/03/01 00:00 [received] PHST- 2018/09/03 00:00 [accepted] PHST- 2018/09/20 06:00 [entrez] PHST- 2018/09/20 06:00 [pubmed] PHST- 2019/11/15 06:00 [medline] PHST- 2018/09/18 00:00 [pmc-release] AID - 10.1038/s41598-018-32215-6 [pii] AID - 32215 [pii] AID - 10.1038/s41598-018-32215-6 [doi] PST - epublish SO - Sci Rep. 2018 Sep 18;8(1):13962. doi: 10.1038/s41598-018-32215-6.