PMID- 30229927
OWN - NLM
STAT- MEDLINE
DCOM- 20190211
LR  - 20190215
IS  - 1097-0096 (Electronic)
IS  - 0091-2751 (Linking)
VI  - 46
IP  - 8
DP  - 2018 Oct
TI  - Short-term effects of levosimendan on strain/strain rate markers in patients with 
      nonischemic dilated cardiomyopathy.
PG  - 527-532
LID - 10.1002/jcu.22627 [doi]
AB  - OBJECTIVE: To investigate whether repetitive measurements of speckle tracking 
      echocardiography (STE)-derived strain (S) and strain rate (SR) could reveal 
      changes in left ventricular function in patients with nonischemic dilated 
      cardiomyopathy treated with levosimendan. METHODS: We included 22 consecutive 
      patients (age 53 +/-12 years) with an ejection fraction (EF) below 35% and New York 
      Heart Association (NYHA) class III-IV symptoms that required intravenous 
      inotropic support despite optimal medical therapy. The absence of any occlusive 
      coronary artery disease was identified via previous coronary angiography in all 
      patients. Echocardiographic variables, including strain/strain rate, and NYHA 
      functional class, were evaluated before and after levosimendan infusion at the 
      72nd hour and one month. RESULTS: The strain and strain rate values for both left 
      and right ventricles were observed to be increased NYHA functional class and left 
      ventricular EF (P <.05). CONCLUSION: STE can successfully completed conventional 
      echocardiography in the evaluation of patients with decompensated heart failure 
      who were treated with levosimendan.
CI  - (c) 2018 Wiley Periodicals, Inc.
FAU - Kiris, Tuncay
AU  - Kiris T
AUID- ORCID: 0000-0001-9793-718X
AD  - Department of Cardiology, Izmir Katip Celebi University Ataturk Training and 
      Research Hospital, Izmir, Turkey.
FAU - Avci, Eyup
AU  - Avci E
AD  - Cardiology Department, Balikesir University Faculty of Medicine, Balikesir, 
      Turkey.
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
DEP - 20180919
PL  - United States
TA  - J Clin Ultrasound
JT  - Journal of clinical ultrasound : JCU
JID - 0401663
RN  - 0 (Cardiotonic Agents)
RN  - 349552KRHK (Simendan)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Cardiomyopathy, Dilated/diagnostic imaging/*drug therapy/physiopathology
MH  - Cardiotonic Agents/pharmacology/*therapeutic use
MH  - Echocardiography/*methods
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Simendan/pharmacology/*therapeutic use
MH  - Treatment Outcome
MH  - Ventricular Function, Left/*drug effects
OTO - NOTNLM
OT  - levosimendan
OT  - nonischemic cardiomyopathy
OT  - strain/strain rate
EDAT- 2018/09/20 06:00
MHDA- 2019/02/12 06:00
CRDT- 2018/09/20 06:00
PHST- 2017/12/13 00:00 [received]
PHST- 2018/05/05 00:00 [revised]
PHST- 2018/06/21 00:00 [accepted]
PHST- 2018/09/20 06:00 [pubmed]
PHST- 2019/02/12 06:00 [medline]
PHST- 2018/09/20 06:00 [entrez]
AID - 10.1002/jcu.22627 [doi]
PST - ppublish
SO  - J Clin Ultrasound. 2018 Oct;46(8):527-532. doi: 10.1002/jcu.22627. Epub 2018 Sep 
      19.