PMID- 30230173
OWN - NLM
STAT- MEDLINE
DCOM- 20190108
LR  - 20190213
IS  - 1463-1326 (Electronic)
IS  - 1462-8902 (Linking)
VI  - 20 Suppl 2
DP  - 2018 Sep
TI  - Pancreatic islet of Langerhans' cytoarchitecture and ultrastructure in normal 
      glucose tolerance and in type 2 diabetes mellitus.
PG  - 137-144
LID - 10.1111/dom.13380 [doi]
AB  - While a number of structural and cellular abnormalities occur in the islet of 
      Langerhans in diabetes, and in particular in type 2 diabetes, the focus has been 
      mostly on the insulin producing beta-cells and only more recently on glucagon 
      producing alpha- and delta-cells. There is ample evidence that in type 2 diabetes 
      mellitus (T2DM), in addition to a progressive decline in beta-cell function and 
      associated insulin resistance in a number of insulin-sensitive tissues, 
      alterations in glucagon secretion are also present and may play an important role 
      in the pathogenesis of hyperglycemia both in the fasting and in the postprandial 
      state. Recently, a number of studies have showed that there are also functional 
      and structural alterations in glucagon-producing alpha-cells and 
      somatostatin-producing delta-cells. Thus, it is becoming increasingly clear that 
      multiple cellular alterations of multiple cell types occur, which adds even more 
      complexity to our understanding of the pathophysiology of this common and severe 
      disease. We believe that persistent efforts to increase the understanding of the 
      pathophysiology of hormone secretion in the islets of Langerhans will also 
      improve our capability to better prevent and treat diabetes mellitus.
CI  - (c) 2018 John Wiley & Sons Ltd.
FAU - Folli, Franco
AU  - Folli F
AUID- ORCID: 0000-0001-9824-5222
AD  - Endocrinology and Metabolism, Department of Health Science, University of Milano, 
      Milan, Italy.
AD  - Department of Medicine, Endocrinology and Metabolism, Azienda Socio-Sanitaria 
      Santi Paolo e Carlo, Milan, Italy.
FAU - La Rosa, Stefano
AU  - La Rosa S
AD  - Institute of Pathology, Lausanne University Hospital, Lausanne, Switzerland.
FAU - Finzi, Giovanna
AU  - Finzi G
AD  - Anatomical Pathology, Ospedale di Circolo Varese, Varese, Italy.
FAU - Davalli, Alberto M
AU  - Davalli AM
AD  - Department of Medicine, Endocrinology and Metabolism, H.S Raffaele, Milan, Italy.
FAU - Galli, Alessandra
AU  - Galli A
AD  - Department of Pharmacological and Biomolecular Sciences, Universita degli Studi 
      di Milano, Milan, Italy.
FAU - Dick, Edward J Jr
AU  - Dick EJ Jr
AD  - Southwest National Primate Research Center, Texas Biomedical Research Institute, 
      San Antonio, Texas.
FAU - Perego, Carla
AU  - Perego C
AD  - Anatomical Pathology, Ospedale di Circolo Varese, Varese, Italy.
FAU - Mendoza, Rodolfo Guardado
AU  - Mendoza RG
AD  - Division of Health Sciences, Department of Medicine and Nutrition, University of 
      Guanajuato, Guanajuato, Mexico.
AD  - Departamento de Investigacion, Hospital Regional de Alta Especialidad del Bajio, 
      Guanajuato, Mexico.
LA  - eng
GR  - P51 OD011133/OD/NIH HHS/United States
PT  - Journal Article
PT  - Review
PL  - England
TA  - Diabetes Obes Metab
JT  - Diabetes, obesity & metabolism
JID - 100883645
RN  - 0 (Amyloid)
RN  - 0 (Blood Glucose)
SB  - IM
EIN - Diabetes Obes Metab. 2018 Dec;20(12):2925. PMID: 30417538
MH  - Amyloid/metabolism
MH  - Animals
MH  - Blood Glucose/*metabolism
MH  - Diabetes Mellitus, Type 2/*pathology
MH  - Glucagon-Secreting Cells/ultrastructure
MH  - Haplorhini
MH  - Humans
MH  - Islets of Langerhans/*cytology/ultrastructure
MH  - Mice
MH  - Models, Animal
MH  - Pancreatic Polypeptide-Secreting Cells/ultrastructure
MH  - Papio
MH  - Rats
MH  - Somatostatin-Secreting Cells/ultrastructure
OTO - NOTNLM
OT  - IAPP
OT  - amyloid deposition
OT  - electron microscopy insulin producing beta-cells
OT  - glucagon producing alpha-cells
OT  - pancreatic islet of Langerhans structure
OT  - somatostatin producing delta-cells
OT  - type 2 diabetes mellitus
OT  - ultrastructure
EDAT- 2018/09/20 06:00
MHDA- 2019/01/09 06:00
CRDT- 2018/09/20 06:00
PHST- 2018/04/23 00:00 [received]
PHST- 2018/05/20 00:00 [revised]
PHST- 2018/05/23 00:00 [accepted]
PHST- 2018/09/20 06:00 [entrez]
PHST- 2018/09/20 06:00 [pubmed]
PHST- 2019/01/09 06:00 [medline]
AID - 10.1111/dom.13380 [doi]
PST - ppublish
SO  - Diabetes Obes Metab. 2018 Sep;20 Suppl 2:137-144. doi: 10.1111/dom.13380.