PMID- 3023042
OWN - NLM
STAT- MEDLINE
DCOM- 19870116
LR  - 20191210
IS  - 0013-9351 (Print)
IS  - 0013-9351 (Linking)
VI  - 41
IP  - 2
DP  - 1986 Dec
TI  - Effect of fluoride on uptake of D-glucose by isolated epithelial cells of rat 
      intestine.
PG  - 388-99
AB  - Inhibition on uptake of D-glucose by isolated intestinal epithelial cells (IIEC) 
      was observed when the fluoride concentration ranged between 0.25 and 5 mM. Active 
      transport was almost completely inhibited at 5 mM. When CaCl2 was added to 
      fluoride, the inhibitory effect on glucose uptake was abolished. Preincubation of 
      IIEC with different concentrations of fluoride (2.5-5.0 mM) for different 
      intervals of time (2-20 min) at different pH levels (6.2-7.8) and temperatures 
      (0-37 degrees C) revealed that the conditions which led to higher uptake of 
      fluoride by IIEC produced maximum inhibition. The degree of inhibition was not 
      appreciably altered by a change in glucose concentrations. A 
      concentration-dependent effect of fluoride on lactic acid and carbon dioxide 
      production by IIEC was also observed.
FAU - Shayiq, R M
AU  - Shayiq RM
FAU - Kidwai, A M
AU  - Kidwai AM
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Environ Res
JT  - Environmental research
JID - 0147621
RN  - EC 7.2.2.13 (Sodium-Potassium-Exchanging ATPase)
RN  - IY9XDZ35W2 (Glucose)
RN  - Q80VPU408O (Fluorides)
SB  - IM
MH  - Animals
MH  - Dose-Response Relationship, Drug
MH  - Epithelium/metabolism
MH  - Fluorides/*pharmacology
MH  - Glucose/*metabolism
MH  - Glycolysis/drug effects
MH  - Hydrogen-Ion Concentration
MH  - In Vitro Techniques
MH  - Intestinal Mucosa/*metabolism
MH  - Male
MH  - Rats
MH  - Sodium-Potassium-Exchanging ATPase/analysis
MH  - Temperature
MH  - Time Factors
EDAT- 1986/12/01 00:00
MHDA- 1986/12/01 00:01
CRDT- 1986/12/01 00:00
PHST- 1986/12/01 00:00 [pubmed]
PHST- 1986/12/01 00:01 [medline]
PHST- 1986/12/01 00:00 [entrez]
AID - S0013-9351(86)80134-7 [pii]
AID - 10.1016/s0013-9351(86)80134-7 [doi]
PST - ppublish
SO  - Environ Res. 1986 Dec;41(2):388-99. doi: 10.1016/s0013-9351(86)80134-7.