PMID- 30230985
OWN - NLM
STAT- MEDLINE
DCOM- 20191025
LR  - 20191025
IS  - 1557-7465 (Electronic)
IS  - 1079-9907 (Linking)
VI  - 38
IP  - 9
DP  - 2018 Sep
TI  - Increased Serum MCP-1 Levels in Systemic Vasculitis Patients with Renal 
      Involvement.
PG  - 406-412
LID - 10.1089/jir.2017.0140 [doi]
AB  - Monocyte chemotactic protein 1 (MCP-1) plays a significant role in inflammation 
      pathways by affecting monocyte/macrophage migration, the number of monocytes and 
      T lymphocytes, and osmosis. Inflammation is closely linked to various types of 
      systematic vasculitis. Here we characterized serum MCP-1 levels in systemic 
      vasculitis patients. This cross-sectional study included serum samples collected 
      from 43 patients with systemic vasculitis and 43 healthy controls (HCs). Serum 
      MCP-1 levels in the samples were measured using commercially available 
      enzyme-linked immunosorbent assay (ELISA) kits. Serum MCP-1 levels were 
      significantly higher in patients with systemic vasculitis relative to HCs 
      (parentheses indicate quartile values) [134.65 (73.74, 262.75) pg/mL versus 59.1 
      (37.41, 90.18) pg/mL, P < 0.001]. Furthermore, systemic vasculitis patients 
      having renal involvement had significantly higher MCP-1 levels relative to 
      patients without renal involvement [196.16 (104.41, 310.35) pg/mL versus 73.74 
      (41.24, 145.95) pg/mL, P = 0.001] and HCs [196.16 (104.41, 310.35) pg/mL versus 
      59.10 (37.41, 90.18) pg/mL, P < 0.001]. Serum MCP-1 levels in systemic vasculitis 
      patients were positively correlated with serum creatinine levels (r = 0.387, 
      P < 0.010) and with 24-h proteinuria (r = 0.404, P < 0.014). Receiver operating 
      characteristic (ROC) analysis showed that the cutoff value for MCP-1 to 
      distinguish systemic vasculitis from HCs was 72.73 pg/mg, and the area under the 
      ROC curve was 0.772. The sensitivity and specificity were 76.7% and 72.1%, 
      respectively. Serum MCP-1 levels were significantly higher in patients with 
      systemic vasculitis than in HCs, especially in patients with renal involvement. 
      Thus, serum MCP-1 has the potential to be a biomarker for systemic vasculitis 
      with renal involvement.
FAU - Liu, Shasha
AU  - Liu S
AD  - The Center for Hypertension of the People's Hospital of Xinjiang Uygur Autonomous 
      Region, Hypertension Institute of Xinjiang China, Xinjiang, China .
FAU - Li, Nanfang
AU  - Li N
AD  - The Center for Hypertension of the People's Hospital of Xinjiang Uygur Autonomous 
      Region, Hypertension Institute of Xinjiang China, Xinjiang, China .
FAU - Zhu, Qing
AU  - Zhu Q
AD  - The Center for Hypertension of the People's Hospital of Xinjiang Uygur Autonomous 
      Region, Hypertension Institute of Xinjiang China, Xinjiang, China .
FAU - Zhu, Bin
AU  - Zhu B
AD  - The Center for Hypertension of the People's Hospital of Xinjiang Uygur Autonomous 
      Region, Hypertension Institute of Xinjiang China, Xinjiang, China .
FAU - Wu, Ting
AU  - Wu T
AD  - The Center for Hypertension of the People's Hospital of Xinjiang Uygur Autonomous 
      Region, Hypertension Institute of Xinjiang China, Xinjiang, China .
FAU - Wang, Guoliang
AU  - Wang G
AD  - The Center for Hypertension of the People's Hospital of Xinjiang Uygur Autonomous 
      Region, Hypertension Institute of Xinjiang China, Xinjiang, China .
FAU - Liu, Shanshan
AU  - Liu S
AD  - The Center for Hypertension of the People's Hospital of Xinjiang Uygur Autonomous 
      Region, Hypertension Institute of Xinjiang China, Xinjiang, China .
FAU - Luo, Qin
AU  - Luo Q
AD  - The Center for Hypertension of the People's Hospital of Xinjiang Uygur Autonomous 
      Region, Hypertension Institute of Xinjiang China, Xinjiang, China .
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Interferon Cytokine Res
JT  - Journal of interferon & cytokine research : the official journal of the 
      International Society for Interferon and Cytokine Research
JID - 9507088
RN  - 0 (Biomarkers)
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Adult
MH  - Biomarkers/blood
MH  - Chemokine CCL2/*blood
MH  - Female
MH  - Humans
MH  - Kidney Diseases/*blood/*complications
MH  - Male
MH  - Systemic Vasculitis/*blood/*complications
OTO - NOTNLM
OT  - MCP-1
OT  - biomarker
OT  - renal involvement
OT  - systemic vasculitis
EDAT- 2018/09/20 06:00
MHDA- 2019/10/28 06:00
CRDT- 2018/09/20 06:00
PHST- 2018/09/20 06:00 [entrez]
PHST- 2018/09/20 06:00 [pubmed]
PHST- 2019/10/28 06:00 [medline]
AID - 10.1089/jir.2017.0140 [doi]
PST - ppublish
SO  - J Interferon Cytokine Res. 2018 Sep;38(9):406-412. doi: 10.1089/jir.2017.0140.