PMID- 30231659 OWN - NLM STAT- MEDLINE DCOM- 20200120 LR - 20200120 IS - 1476-4954 (Electronic) IS - 1476-4954 (Linking) VI - 32 IP - 19 DP - 2019 Oct TI - Effects of mode of delivery on pro-oxidant/antioxidant balance in fetal circulation. PG - 3294-3299 LID - 10.1080/14767058.2018.1526911 [doi] AB - Objective: This study was undertaken to assess the influence of mode of delivery on the balance between pro-oxidant/antioxidant systems in fetal circulation. Materials and methods: Both umbilical arterial and venous blood samples were obtained from 37 pregnant women who delivered by spontaneous vaginal delivery (VD group) and from 29 pregnant women who delivered by elective cesarean section (CS group). Oxidative stress and antioxidant activity were evaluated by reactive oxygen metabolites (d-ROMs) and biological antioxidant potential (BAP), respectively. Results: The d-ROMs values of the VD group were higher than that of the CS group in both umbilical arterial and venous blood and these differences were found to be statistically significant (p < .01 and p < .01, respectively). The BAP values of only the umbilical arterial blood were found to be statistically significant (p < .01), with values from the VD group being higher than those of the CS group. In all measurements, the d-ROMs values averaged below 120 CARR U and BAP values averaged above 2200 micromol/L. The ratio of BAP/d-ROMs difference was found to be statistically significant (p < .01) only in the umbilical venous blood, with ratios in the VD group being lower than those in the CS group. Conclusions: Our statistical analyses suggest that vaginal delivery has an effect on increasing oxidative stress as a result of the stress of labor and that an elective cesarean section does not impair the mother's oxidative stress status. Furthermore, the high BAP values in all the measurements suggest that neonates just after birth have the ability to cope with oxidative stress. Rationale In many studies, the diversity of views on the influence of mode of delivery on the redox status of neonates is likely to be caused by the use of different biomarkers to measure either the oxidative stress, the antioxidant activity, or both. Furthermore, incomplete explanation for sampling cord blood in these studies, either arterial, venous blood or both, complicates matters. To solve the above, this study was designed to assess the effects of mode of delivery on both pro-oxidants, via d-ROMs, and antioxidants, via BAP, in both umbilical arterial and venous blood samples obtained just after birth. There are no existing studies of BAP in both umbilical arterial and venous blood to which we can refer. In conclusion, our study suggests that the pro-oxidant/antioxidant balance in neonates just after birth is better than may be expected when compared to the potentials of adults (including pregnant mothers) according to interpretations of BAP/d-ROMs. This can be understood that neonates may have already been endowed with the ability to cope with oxidative stress, as informed by high BAP values in both umbilical arterial and venous blood. Vaginal delivery may have an effect on increasing oxidative stress as a result of the stress of labors (as measured by d-ROMs), and an elective cesarean section, which has better BAP/d-ROMs in umbilical venous blood than that of vaginal delivery, may not impair the mother's oxidative stress status. FAU - Kobayashi, Hisaaki AU - Kobayashi H AUID- ORCID: 0000-0002-3763-9970 AD - a Department of Obstetrics , Nishisaitama Chuo National Hospital , Tokorozawa , Japan. AD - b Department of Gynecology , Nishisaitama Chuo National Hospital , Tokorozawa , Japan. FAU - Iorio, Eugenio Luigi AU - Iorio EL AD - c International Observatory of Oxidative Stress , Salerno , Italy. FAU - Yoshino, Akihiro AU - Yoshino A AD - a Department of Obstetrics , Nishisaitama Chuo National Hospital , Tokorozawa , Japan. AD - b Department of Gynecology , Nishisaitama Chuo National Hospital , Tokorozawa , Japan. LA - eng PT - Comparative Study PT - Journal Article DEP - 20181029 PL - England TA - J Matern Fetal Neonatal Med JT - The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians JID - 101136916 RN - 0 (Antioxidants) RN - 0 (Biomarkers) RN - 0 (Oxidants) SB - IM MH - Adult MH - Antioxidants/*metabolism MH - Biomarkers/blood MH - Cesarean Section/adverse effects MH - Cohort Studies MH - Delivery, Obstetric/adverse effects/*methods MH - Female MH - Fetal Blood/chemistry/*metabolism MH - Humans MH - Infant, Newborn MH - Male MH - Oxidants/*blood MH - Oxidative Stress/physiology MH - Pregnancy OTO - NOTNLM OT - Biological antioxidant potential (BAP) OT - cesarean section OT - oxidative stress status OT - reactive oxygen metabolites (d-ROMs) OT - vaginal delivery EDAT- 2018/09/21 06:00 MHDA- 2020/01/21 06:00 CRDT- 2018/09/21 06:00 PHST- 2018/09/21 06:00 [pubmed] PHST- 2020/01/21 06:00 [medline] PHST- 2018/09/21 06:00 [entrez] AID - 10.1080/14767058.2018.1526911 [doi] PST - ppublish SO - J Matern Fetal Neonatal Med. 2019 Oct;32(19):3294-3299. doi: 10.1080/14767058.2018.1526911. Epub 2018 Oct 29.