PMID- 30232031
OWN - NLM
STAT- MEDLINE
DCOM- 20181113
LR  - 20181113
IS  - 1873-6351 (Electronic)
IS  - 0278-6915 (Linking)
VI  - 121
DP  - 2018 Nov
TI  - Decabromodiphenyl ether (BDE-209) enhances foam cell formation in human 
      macrophages via augmenting Toll-like receptor 4-dependent lipid uptake.
PG  - 367-373
LID - S0278-6915(18)30668-9 [pii]
LID - 10.1016/j.fct.2018.09.024 [doi]
AB  - Growing epidemiological evidence is substantiating an association between 
      exposure to persistent organic pollutants (POPs) and incidence of 
      atherosclerosis. Decabromodiphenyl ether (BDE-209) is a new POP which presents 
      extensively in human populations; whether this contaminant is potentially 
      arteriosclerotic remains unclear. In this study, we investigated the effects of 
      BDE-209 on macrophage-derived foam cell formation, a hallmark of early 
      atherosclerosis, using THP-1-derived macrophages incubated with oxidized 
      low-density lipoprotein (oxLDL) as a foam cell model. The results showed that 
      6.25, 12.5 and 25.0 muM of BDE-209 significantly enhanced lipid accumulation 
      inside the foam cells, in a dose-dependent manner. Further mechanism assays 
      suggested that BDE-209 significantly increased the expression of Toll-like 
      receptor 4 (TLR4), a signal transducing integral membrane protein mediating lipid 
      uptake in macrophages, at both the mRNA and protein levels. In contrast, there 
      was no significant changes for several key regulators involving in lipid efflux, 
      lipogenesis, and lipid oxidation in macrophages. Furthermore, the augmented lipid 
      accumulation was almost completely abrogated by treatment with an anti-TLR4 
      antibody. Together, these data illustrate that BDE-209 enhances oxLDL-induced 
      macrophage foam cell formation via augmenting TLR4-dependent lipid uptake in the 
      cells.
CI  - Copyright (c) 2018 Elsevier Ltd. All rights reserved.
FAU - Zhi, Hui
AU  - Zhi H
AD  - School of Basic Medical Sciences, Wannan Medical College, Wuhu, 241003, China; 
      Department of Hypertension and Vascular Disease, The First Affiliated Hospital, 
      Sun Yat-sen University, Guangzhou, 510080, China.
FAU - Wu, Jiang-Ping
AU  - Wu JP
AD  - College of Environmental Science and Engineering, Anhui Normal University, Wuhu, 
      241003, China. Electronic address: jpwu@ahnu.edu.cn.
FAU - Lu, Lin-Ming
AU  - Lu LM
AD  - School of Basic Medical Sciences, Wannan Medical College, Wuhu, 241003, China.
FAU - Li, Yan
AU  - Li Y
AD  - Department of Cardiology, The First Affiliated Hospital of Jinan University, 
      Guangzhou, 510630, China.
FAU - Chen, Xiao-Yun
AU  - Chen XY
AD  - College of Environmental Science and Engineering, Anhui Normal University, Wuhu, 
      241003, China.
FAU - Tao, Jun
AU  - Tao J
AD  - Department of Hypertension and Vascular Disease, The First Affiliated Hospital, 
      Sun Yat-sen University, Guangzhou, 510080, China. Electronic address: 
      taojungz@yahoo.com.
FAU - Mai, Bi-Xian
AU  - Mai BX
AD  - State Key Laboratory of Organic Geochemistry, Guangzhou Institute of 
      Geochemistry, Chinese Academy of Sciences, Guangzhou, 510640, China.
LA  - eng
PT  - Journal Article
DEP - 20180916
PL  - England
TA  - Food Chem Toxicol
JT  - Food and chemical toxicology : an international journal published for the British 
      Industrial Biological Research Association
JID - 8207483
RN  - 0 (Halogenated Diphenyl Ethers)
RN  - 0 (TLR4 protein, human)
RN  - 0 (Toll-Like Receptor 4)
RN  - N80BQ29A0H (decabromobiphenyl ether)
SB  - IM
MH  - Cell Line
MH  - Cell Survival
MH  - Dose-Response Relationship, Drug
MH  - Foam Cells/*drug effects
MH  - Gene Expression Regulation/drug effects
MH  - Halogenated Diphenyl Ethers/*pharmacology
MH  - Humans
MH  - Lipid Metabolism/*drug effects
MH  - Macrophages/*drug effects
MH  - THP-1 Cells
MH  - Toll-Like Receptor 4/*metabolism
OTO - NOTNLM
OT  - Atherosclerosis
OT  - BDE-209
OT  - Foam cell formation
OT  - Macrophages
OT  - TLR4
EDAT- 2018/09/21 06:00
MHDA- 2018/11/14 06:00
CRDT- 2018/09/21 06:00
PHST- 2018/08/31 00:00 [received]
PHST- 2018/09/13 00:00 [revised]
PHST- 2018/09/15 00:00 [accepted]
PHST- 2018/09/21 06:00 [pubmed]
PHST- 2018/11/14 06:00 [medline]
PHST- 2018/09/21 06:00 [entrez]
AID - S0278-6915(18)30668-9 [pii]
AID - 10.1016/j.fct.2018.09.024 [doi]
PST - ppublish
SO  - Food Chem Toxicol. 2018 Nov;121:367-373. doi: 10.1016/j.fct.2018.09.024. Epub 
      2018 Sep 16.