PMID- 30232307
OWN - NLM
STAT- MEDLINE
DCOM- 20190503
LR  - 20190503
IS  - 1348-4540 (Electronic)
IS  - 0918-8959 (Linking)
VI  - 65
IP  - 12
DP  - 2018 Dec 28
TI  - Rescue of the fetal damage associated with high intrauterine pressure by 
      17beta-estradiol injection in ovariectomized progesterone-treated pregnant mice.
PG  - 1219-1224
LID - 10.1507/endocrj.EJ18-0302 [doi]
AB  - The present study examined the effects of progesterone (P) and 17beta-estradiol (E2) 
      on fetal damage and intrauterine pressure in ovariectomized pregnant mice. The 
      mice were ovariectomized on gestational day (GD) 9 (copulation plug = GD 0), and 
      daily subcutaneous injection of various doses of P (2, 3 or 4 mg) or 4 mg P plus 
      E2 (0.05 or 0.1 mug) was given thereafter. Although P alone increased percentage 
      of normal fetuses on GD 17 dose-dependently, fetal injury with edematous 
      hematomata on their extremities was frequently observed. In the group treated 
      with 4 mg P, the injured fetus was found at the highest percentage (18%) and 
      intrauterine pressure was significantly higher than that in intact pregnant mice 
      (controls). No injured fetus on GD 17 was found by the treatment with 4 mg P plus 
      0.05 or 0.1 mug E2, and the treatments decreased the intrauterine pressure to the 
      level of controls. Percentage of normal fetuses in the ovariectomized mice 
      treated with 4 mg P plus 0.05 mug E2 was similar to that of controls, while that 
      in the ovariectomized mice treated with 4 mg P plus 0.1 mug E2 markedly decreased. 
      The results suggest that estrogen decreases intrauterine pressure to defend fetal 
      damage in ovariectomized P-treated mice, and a high estrogen level interrupted 
      pregnancy while keeping this estrogen action.
FAU - Tadotsu, Daisuke
AU  - Tadotsu D
AD  - Department of Advanced Pathobiology, Graduate School of Life and Environmental 
      Sciences, Osaka Prefecture University, Osaka 598-8531, Japan.
FAU - Kawate, Noritoshi
AU  - Kawate N
AD  - Department of Advanced Pathobiology, Graduate School of Life and Environmental 
      Sciences, Osaka Prefecture University, Osaka 598-8531, Japan.
FAU - Tamada, Hiromichi
AU  - Tamada H
AD  - Department of Advanced Pathobiology, Graduate School of Life and Environmental 
      Sciences, Osaka Prefecture University, Osaka 598-8531, Japan.
LA  - eng
PT  - Journal Article
DEP - 20180919
PL  - Japan
TA  - Endocr J
JT  - Endocrine journal
JID - 9313485
RN  - 4G7DS2Q64Y (Progesterone)
RN  - 4TI98Z838E (Estradiol)
SB  - IM
MH  - Animals
MH  - Estradiol/*pharmacology/therapeutic use
MH  - Female
MH  - Fetal Diseases/*drug therapy
MH  - Mice
MH  - Ovariectomy
MH  - Pregnancy
MH  - Pressure
MH  - Progesterone/*pharmacology/therapeutic use
MH  - Uterus/*drug effects
OTO - NOTNLM
OT  - Estrogen
OT  - Fetal damage
OT  - Intrauterine pressure
OT  - Mice
OT  - Progesterone
EDAT- 2018/09/21 06:00
MHDA- 2019/05/06 06:00
CRDT- 2018/09/21 06:00
PHST- 2018/09/21 06:00 [pubmed]
PHST- 2019/05/06 06:00 [medline]
PHST- 2018/09/21 06:00 [entrez]
AID - 10.1507/endocrj.EJ18-0302 [doi]
PST - ppublish
SO  - Endocr J. 2018 Dec 28;65(12):1219-1224. doi: 10.1507/endocrj.EJ18-0302. Epub 2018 
      Sep 19.