PMID- 30232763
OWN - NLM
STAT- MEDLINE
DCOM- 20190723
LR  - 20190723
IS  - 0065-2598 (Print)
IS  - 0065-2598 (Linking)
VI  - 1086
DP  - 2018
TI  - Pharmaceutical Intervention of Aging.
PG  - 235-254
LID - 10.1007/978-981-13-1117-8_15 [doi]
AB  - The aging population represents a significant worldwide socioeconomic challenge. 
      Aging is an inevitable and multifactorial biological process and primary risk 
      factor for most age-related diseases, such as cardiovascular diseases, cancers, 
      type 2 diabetes mellitus (T2DM), and neurodegenerative diseases. Pharmacological 
      interventions targeting aging appear to be a more effective approach in 
      preventing age-related disorders compared with the treatments targeted to 
      specific disease. In this chapter, we focus on the latest findings on molecular 
      compounds that mimic caloric restriction (CR), supplement nicotinamide adenine 
      dinucleotide (NAD(+)) levels, and eliminate senescent cells, including metformin, 
      resveratrol, spermidine, rapamycin, NAD(+) boosters, as well as senolytics. All 
      these interventions modulate the determinants and pathways responsible for 
      aging/longevity, such as the kinase target of rapamycin (TOR), AMP-activated 
      protein kinase (AMPK), sirtuins, and insulin-like growth factor (IGF-1) signaling 
      (Fig. 15.1).
FAU - Qian, Minxian
AU  - Qian M
AD  - Guangdong Key Laboratory of Genome Stability and Human Disease Prevention, 
      Medical Research Center, Department of Biochemistry and Molecular Biology, 
      Shenzhen University Health Science Center, Shenzhen, China.
FAU - Liu, Baohua
AU  - Liu B
AD  - Guangdong Key Laboratory of Genome Stability and Human Disease Prevention, 
      Medical Research Center, Department of Biochemistry and Molecular Biology, 
      Shenzhen University Health Science Center, Shenzhen, China. ppliew@szu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Adv Exp Med Biol
JT  - Advances in experimental medicine and biology
JID - 0121103
RN  - 0 (Pharmaceutical Preparations)
RN  - 0U46U6E8UK (NAD)
MH  - *Aging
MH  - Caloric Restriction
MH  - Cardiovascular Diseases/prevention & control
MH  - Cellular Senescence
MH  - Diabetes Mellitus, Type 2/prevention & control
MH  - Humans
MH  - Longevity
MH  - NAD
MH  - Neoplasms/prevention & control
MH  - Neurodegenerative Diseases/prevention & control
MH  - *Pharmaceutical Preparations
MH  - Risk Factors
MH  - Signal Transduction/drug effects
OTO - NOTNLM
OT  - Age-related diseases
OT  - Aging
OT  - Pharmaceutical intervention
EDAT- 2018/09/21 06:00
MHDA- 2019/07/25 06:00
CRDT- 2018/09/21 06:00
PHST- 2018/09/21 06:00 [entrez]
PHST- 2018/09/21 06:00 [pubmed]
PHST- 2019/07/25 06:00 [medline]
AID - 10.1007/978-981-13-1117-8_15 [doi]
PST - ppublish
SO  - Adv Exp Med Biol. 2018;1086:235-254. doi: 10.1007/978-981-13-1117-8_15.