PMID- 30232930
OWN - NLM
STAT- MEDLINE
DCOM- 20190114
LR  - 20240402
IS  - 1744-8069 (Electronic)
IS  - 1744-8069 (Linking)
VI  - 14
DP  - 2018 Jan-Dec
TI  - Surgical incision induces learning impairment in mice partially through 
      inhibition of the brain-derived neurotrophic factor signaling pathway in the 
      hippocampus and amygdala.
PG  - 1744806918805902
LID - 10.1177/1744806918805902 [doi]
LID - 1744806918805902
AB  - Surgical incision-induced nociception contributes to the occurrence of 
      postoperative cognitive dysfunction. However, the exact mechanisms involved 
      remain unclear. Brain-derived neurotrophic factor (BDNF) has been demonstrated to 
      improve fear learning ability. In addition, BDNF expression is influenced by the 
      peripheral nociceptive stimulation. Therefore, we hypothesized that surgical 
      incision-induced nociception may cause learning impairment by inhibiting the 
      BDNF/tropomyosin-related kinase B (TrkB) signaling pathway. The fear conditioning 
      test, enzyme-linked immunosorbent assay, and Western blot analyses were used to 
      confirm our hypothesis and determine the effect of a plantar incision on the fear 
      learning and the BDNF/TrkB signaling pathway in the hippocampus and amygdala. The 
      freezing times in the context test and the tone test were decreased after the 
      plantar incision. A eutectic mixture of local anesthetics attenuated plantar 
      incision-induced postoperative pain and fear learning impairment. ANA-12, a 
      selective TrkB antagonist, abolished the improvement in fear learning and the 
      activation of the BDNF signaling pathway induced by eutectic mixture of local 
      anesthetics. Based on these results, surgical incision-induced postoperative 
      pain, which was attenuated by postoperative analgesia, caused learning impairment 
      in mice partially by inhibiting the BDNF signaling pathway. These findings 
      provide insights into the mechanism underlying surgical incision-induced 
      postoperative cognitive function impairment.
FAU - Liu, Zhen
AU  - Liu Z
AD  - 1 Department of Anesthesiology, Peking Union Medical College Hospital, Beijing, 
      China.
AD  - 2 Department of Anesthesiology, Beijing Hospital, Beijing, China.
FAU - Liu, Fan
AU  - Liu F
AD  - 3 Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, 
      Department of Human Anatomy, Histology and Embryology, Neuroscience Center, 
      School of Basic Medicine, Joint Laboratory of Anesthesia and Pain, Peking Union 
      Medical College, Beijing, China.
FAU - Liu, Xiaowen
AU  - Liu X
AD  - 1 Department of Anesthesiology, Peking Union Medical College Hospital, Beijing, 
      China.
AD  - 4 Department of Anesthesiology, China-Japan Friendship Hospital, Beijing, China.
FAU - Ma, Chao
AU  - Ma C
AD  - 3 Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, 
      Department of Human Anatomy, Histology and Embryology, Neuroscience Center, 
      School of Basic Medicine, Joint Laboratory of Anesthesia and Pain, Peking Union 
      Medical College, Beijing, China.
FAU - Zhao, Jing
AU  - Zhao J
AD  - 4 Department of Anesthesiology, China-Japan Friendship Hospital, Beijing, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180920
PL  - United States
TA  - Mol Pain
JT  - Molecular pain
JID - 101242662
RN  - 0 (ANA 12 compound)
RN  - 0 (Azepines)
RN  - 0 (Benzamides)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Cytokines)
RN  - EC 2.7.10.1 (Receptor, trkB)
SB  - IM
MH  - Amygdala/drug effects/*metabolism
MH  - Animals
MH  - Azepines/therapeutic use
MH  - Benzamides/therapeutic use
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Cytokines/metabolism
MH  - Exploratory Behavior/drug effects
MH  - Fear/drug effects
MH  - Gene Expression Regulation/drug effects
MH  - Hippocampus/drug effects/*metabolism
MH  - Learning Disabilities/drug therapy/*etiology/*pathology
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Plantar Plate/innervation/pathology
MH  - Receptor, trkB/antagonists & inhibitors
MH  - Signal Transduction
MH  - Surgical Wound/*complications
MH  - Time Factors
PMC - PMC6194924
OTO - NOTNLM
OT  - brain-derived neurotrophic factor
OT  - learning impairment
OT  - postoperative cognitive dysfunction
OT  - surgical incision
OT  - tropomyosin-related kinase B
EDAT- 2018/09/21 06:00
MHDA- 2019/01/15 06:00
PMCR- 2018/09/20
CRDT- 2018/09/21 06:00
PHST- 2018/09/21 06:00 [pubmed]
PHST- 2019/01/15 06:00 [medline]
PHST- 2018/09/21 06:00 [entrez]
PHST- 2018/09/20 00:00 [pmc-release]
AID - 10.1177_1744806918805902 [pii]
AID - 10.1177/1744806918805902 [doi]
PST - ppublish
SO  - Mol Pain. 2018 Jan-Dec;14:1744806918805902. doi: 10.1177/1744806918805902. Epub 
      2018 Sep 20.