PMID- 30233298 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20201001 IS - 1662-4548 (Print) IS - 1662-453X (Electronic) IS - 1662-453X (Linking) VI - 12 DP - 2018 TI - Prenatal Deltamethrin Exposure-Induced Cognitive Impairment in Offspring Is Ameliorated by Memantine Through NMDAR/BDNF Signaling in Hippocampus. PG - 615 LID - 10.3389/fnins.2018.00615 [doi] LID - 615 AB - Background: Pyrethroids have been widely used in residential and agricultural areas. However, little is known about the effects of prenatal exposure to deltamethrin on cognition in early development of offspring. In this study, the effects of prenatal exposure to deltamethrin on learning and memory abilities, N-methyl-D-aspartate receptor (NMDAR) subunits, brain derived neurotrophic factor (BDNF), Tyrosine kinase B (TrkB) receptor, and phosphorylated cAMP response element binding protein (pCREB) in the hippocampus of offspring rats were investigated. Experimental Approaches: Groups each of six female SD rats, as F0-generation, were administered with deltamethrin (0, 0.54, 1.35, and 2.7, 9 mg/kg), or memantine (10 mg/kg), or co-administered with deltamethrin (9 mg/kg) and memantine (10 mg/kg) daily by gavage during pregnancy. The learning and memory ability was evaluated using Morris water maze (MWM) task on postnatal day 21. The expression of NMDAR (GluN1, GluN2A, and GluN2B), BDNF, pTrkB/TrkB, and pCREB/CREB in hippocampus were assessed with western blotting. Results: Prenatal exposure to a relatively low dose of deltamethrin (2.7, 1.35, and 0.54 mg/kg) had no impact on learning and memory abilities or the expression of NMDAR, BDNF, pTrkB, and pCREB in the hippocampus of the exposed offspring. The group treated with 9 mg/kg deltamethrin showed impaired cognitive abilities and decreased expression levels of GluN1, GluN2A, GluN2B, BDNF, pCREB/CREB, and pTrkB/TrkB in the hippocampus. However, the declined cognitive ability were ameliorated by memantine treatment with increased GluN1, GluN2A, GluN2B, BDNF, pCREB/CREB, and pTrkB/TrkB expression in the hippocampus. Conclusion and Implications: Prenatal exposure to a relatively high does of deltamethrin (9 mg/kg) alters cognition in offsprings and that this cognitive dysfunction can be ameliorated by memantine treatment. Moreover, NMDAR/BDNF signaling may be associated with the effects of prenatal exposure to deltamethrin on cognitive ability in offspring. FAU - Zhang, Chao AU - Zhang C AD - Department of Women and Child Health, School of Public Health, Kunming Medical University, Kunming, China. AD - Department of Pediatrics, Weifang Yidu Central Hospital, Shandong, China. FAU - Xu, Qinghua AU - Xu Q AD - Department of Women and Child Health, School of Public Health, Kunming Medical University, Kunming, China. FAU - Xiao, Xia AU - Xiao X AD - Department of Women and Child Health, School of Public Health, Kunming Medical University, Kunming, China. FAU - Li, Weihao AU - Li W AD - School of Stomatology, Kunming Medical University, Kunming, China. FAU - Kang, Qiang AU - Kang Q AD - Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Kunming Medical University, Kunming, China. FAU - Zhang, Xiong AU - Zhang X AD - Department of Women and Child Health, School of Public Health, Kunming Medical University, Kunming, China. FAU - Wang, Tinghua AU - Wang T AD - Department of Experimental Zoology, Kunming Medical University, Kunming, China. FAU - Li, Yan AU - Li Y AD - Department of Women and Child Health, School of Public Health, Kunming Medical University, Kunming, China. LA - eng PT - Journal Article DEP - 20180904 PL - Switzerland TA - Front Neurosci JT - Frontiers in neuroscience JID - 101478481 EIN - Front Neurosci. 2018 Oct 02;12:720. PMID: 30344474 PMC - PMC6131609 OTO - NOTNLM OT - BDNF OT - CREB OT - N-methyl-D-aspartate receptor OT - TrkB OT - cognitive impairment OT - deltamethrin EDAT- 2018/09/21 06:00 MHDA- 2018/09/21 06:01 PMCR- 2018/01/01 CRDT- 2018/09/21 06:00 PHST- 2018/06/20 00:00 [received] PHST- 2018/08/14 00:00 [accepted] PHST- 2018/09/21 06:00 [entrez] PHST- 2018/09/21 06:00 [pubmed] PHST- 2018/09/21 06:01 [medline] PHST- 2018/01/01 00:00 [pmc-release] AID - 10.3389/fnins.2018.00615 [doi] PST - epublish SO - Front Neurosci. 2018 Sep 4;12:615. doi: 10.3389/fnins.2018.00615. eCollection 2018.