PMID- 30233362
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230928
IS  - 1663-9812 (Print)
IS  - 1663-9812 (Electronic)
IS  - 1663-9812 (Linking)
VI  - 9
DP  - 2018
TI  - The Bone-Protecting Efficiency of Chinese Medicines Compared With Western 
      Medicines in Rheumatoid Arthritis: A Systematic Review and Meta-Analysis of 
      Comparative Studies.
PG  - 914
LID - 10.3389/fphar.2018.00914 [doi]
LID - 914
AB  - Background: Rheumatoid Arthritis (RA) is a systemic autoimmune disease leading to 
      joint destruction. The prevention of bone and cartilage destruction has received 
      increased attention in recent years. Objective: To evaluate the current evidences 
      regarding the bone-protecting efficacy of Chinese medicine or the combination of 
      Chinese medicine and Western medicine for RA. Methods: We comprehensively 
      searched PubMed, Embase, the Cochrane Library (www.thecochranelibrary.com), the 
      China National Knowledge Infrastructure (CNKI), the Database for Chinese 
      Technical Periodicals (VIP), and SinoMed. We then performed a systematic review 
      and cumulative meta-analysis of all randomized controlled trials (RCTs) assessing 
      the two therapy methods. Results: Sixteen studies including 1,171 patients were 
      included in the final analysis. The results showed that Chinese medicine could 
      significantly improve the bone mineral density (BMD) (mean difference [MD] = 0.05 
      /g.cm(-2), 95% CI [0.03, 0.08], P < 0.00001), and decrease the serum matrix 
      metalloproteinase 3 (MMP-3) ([SMD] = -2.84, 95% CI [-4.22, -1.47], P < 0.0001). 
      Conclusions: Chinese medicine may provide an efficiently alternative choice for 
      the treatment of RA in terms of the bone-protecting efficiency. Given the 
      inherent limitations of the included studies, future well-designed RCTs are 
      required to confirm and update the findings of this analysis.
FAU - Cai, Xiao
AU  - Cai X
AD  - The Second Clinical College, Guangzhou University of Chinese Medicine, Guangdong 
      Provincial Hospital of Chinese Medicine, Guangzhou, China.
FAU - Chen, Xiu-Min
AU  - Chen XM
AD  - The Second Clinical College, Guangzhou University of Chinese Medicine, Guangdong 
      Provincial Hospital of Chinese Medicine, Guangzhou, China.
FAU - Xia, Xuan
AU  - Xia X
AD  - The Second Clinical College, Guangzhou University of Chinese Medicine, Guangdong 
      Provincial Hospital of Chinese Medicine, Guangzhou, China.
FAU - Bao, Kun
AU  - Bao K
AD  - The Second Clinical College, Guangzhou University of Chinese Medicine, Guangdong 
      Provincial Hospital of Chinese Medicine, Guangzhou, China.
FAU - Wang, Rong-Rong
AU  - Wang RR
AD  - The Second Clinical College, Guangzhou University of Chinese Medicine, Guangdong 
      Provincial Hospital of Chinese Medicine, Guangzhou, China.
FAU - Peng, Jian-Hong
AU  - Peng JH
AD  - Department of Rheumatology, Dongguan Hospital of Traditional Chinese Medicine, 
      Dongguan, China.
FAU - Liu, Hai-Jun
AU  - Liu HJ
AD  - Department of Rheumatology, Panyu District Central Hospital, Guangzhou, China.
FAU - Yang, Qiao-Wen
AU  - Yang QW
AD  - The Second Clinical College, Guangzhou University of Chinese Medicine, Guangdong 
      Provincial Hospital of Chinese Medicine, Guangzhou, China.
FAU - Yan, Jing-Yao
AU  - Yan JY
AD  - The Second Clinical College, Guangzhou University of Chinese Medicine, Guangdong 
      Provincial Hospital of Chinese Medicine, Guangzhou, China.
FAU - Wang, Mao-Jie
AU  - Wang MJ
AD  - The Second Clinical College, Guangzhou University of Chinese Medicine, Guangdong 
      Provincial Hospital of Chinese Medicine, Guangzhou, China.
AD  - University Medicial Center Utrecht, Utrecht, Netherlands.
FAU - Yu, Hua
AU  - Yu H
AD  - State Key Laboratory of Quality Research in Chinese Medicine, Institute of 
      Chinese Medical Sciences, University of Macau, Taipa, Macau.
FAU - Lu, Jin-Jian
AU  - Lu JJ
AD  - State Key Laboratory of Quality Research in Chinese Medicine, Institute of 
      Chinese Medical Sciences, University of Macau, Taipa, Macau.
FAU - Hu, Yuan-Jia
AU  - Hu YJ
AD  - State Key Laboratory of Quality Research in Chinese Medicine, Institute of 
      Chinese Medical Sciences, University of Macau, Taipa, Macau.
FAU - Jakobsson, Per-Johan
AU  - Jakobsson PJ
AD  - Rheumatology Unit, Department of Medicine, Karolinska Institutet and Rheumatology 
      Clinic, Karolinska University Hospital Solna, Stockholm, Sweden.
FAU - Wen, Ze-Huai
AU  - Wen ZH
AD  - The Second Clinical College, Guangzhou University of Chinese Medicine, Guangdong 
      Provincial Hospital of Chinese Medicine, Guangzhou, China.
AD  - Key Unit of Methodology in Clinical Research, The Second Affiliated Hospital, 
      Guangzhou University of Chinese Medicine, Guangdong Provincial Hospital of 
      Chinese Medicine, Guangzhou, China.
FAU - Huang, Run-Yue
AU  - Huang RY
AD  - The Second Clinical College, Guangzhou University of Chinese Medicine, Guangdong 
      Provincial Hospital of Chinese Medicine, Guangzhou, China.
AD  - Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese 
      Medicine Syndrome, Guangzhou, China.
FAU - Huang, Qing-Chun
AU  - Huang QC
AD  - The Second Clinical College, Guangzhou University of Chinese Medicine, Guangdong 
      Provincial Hospital of Chinese Medicine, Guangzhou, China.
LA  - eng
PT  - Journal Article
DEP - 20180830
PL  - Switzerland
TA  - Front Pharmacol
JT  - Frontiers in pharmacology
JID - 101548923
PMC - PMC6134841
OTO - NOTNLM
OT  - Chinese medicine
OT  - Rheumatoid Arthritis (RA)
OT  - bone-protecting efficiency
OT  - meta-analysis
OT  - systematic review
EDAT- 2018/09/21 06:00
MHDA- 2018/09/21 06:01
PMCR- 2018/08/30
CRDT- 2018/09/21 06:00
PHST- 2018/05/11 00:00 [received]
PHST- 2018/07/25 00:00 [accepted]
PHST- 2018/09/21 06:00 [entrez]
PHST- 2018/09/21 06:00 [pubmed]
PHST- 2018/09/21 06:01 [medline]
PHST- 2018/08/30 00:00 [pmc-release]
AID - 10.3389/fphar.2018.00914 [doi]
PST - epublish
SO  - Front Pharmacol. 2018 Aug 30;9:914. doi: 10.3389/fphar.2018.00914. eCollection 
      2018.