PMID- 30233424
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1664-0640 (Print)
IS  - 1664-0640 (Electronic)
IS  - 1664-0640 (Linking)
VI  - 9
DP  - 2018
TI  - Hydrogen Sulfide Antagonizes Chronic Restraint Stress-Induced Depressive-Like 
      Behaviors via Upregulation of Adiponectin.
PG  - 399
LID - 10.3389/fpsyt.2018.00399 [doi]
LID - 399
AB  - Backgroud: Chronic restraint stress (CRS) induces depressive-like behaviors in 
      rodents, which involves dysregulation of hippocampal synapse formation and 
      excessive autophagy. Adiponectin has antidepressant activity. Hydrogen sulfide 
      (H(2)S) is a novel gasotransmitter. The present work was to investigate whether 
      H(2)S antagonizes CRS-induced depressive-like behaviors in rats and to explore 
      whether its potential mechanism involves ameliorated synaptic and autophagic 
      dysregulation by upregulation of adiponectin. Methods: Depressive-like behavior 
      was analyzed by the tail suspension test (TST), novelty suppressed feeding test 
      (NSFT), and open field test (OFT). The structure of autophagy was observed under 
      transmission electron microscopy. The expressions of adiponectin, beclin1, and 
      sequestosome 1 (p62/SQSTMI) protein in hippocampus were measured by Western blot. 
      The levels of synapsin1 (SYN1) in the hippocampus were calculated by Western blot 
      and immunofluorescence technique. Results: The behavior experiments, including 
      TST, NSFT, and OFT, showed that NaHS (a donor of H(2)S) reduced CRS-induced 
      depressive-like behaviors. NaHS decreased the loss of hippocampal synapse as 
      evidenced by increased the level of SYN1 in the hippocampus of CRS-exposed rats. 
      NaHS rescued CRS-induced excessive hippocampal autophagy as evidenced by declines 
      in the number of autophagosomes and the expression of beclin1 as well as increase 
      in the expression of P62 in the hippocampus of CRS-exposed rats. NaHS upregulated 
      hippocampal adiponectin expression in the CRS-exposed rats. Furthermore, 
      neutralizing adiponectin by Anti-acrp30 reversed the protective response of NaHS 
      to CRS-produced depressive-like behaviors as well as hippocampal synaptic 
      disruption and excessive autophagy. Conclusion: H(2)S mitigates CRS-induced 
      depressive behavior via upregulation of adiponectin, which in turn results in 
      amelioration in hippocampal synapse formation dysfunction and excessive 
      autophagy.
FAU - Tian, Qing
AU  - Tian Q
AD  - Institute of Neuroscience, Medical College, University of South China, Hengyang, 
      China.
FAU - Chen, Lei
AU  - Chen L
AD  - Institute of Neuroscience, Medical College, University of South China, Hengyang, 
      China.
AD  - Institute of Clinical Research, Affiliated Nanhua Hospital, University of South 
      China, Hengyang, China.
FAU - Luo, Bang
AU  - Luo B
AD  - Institute of Neuroscience, Medical College, University of South China, Hengyang, 
      China.
AD  - Institute of Clinical Research, the First Affiliated Hospital, University of 
      South China, Hengyang, China.
FAU - Wang, Ai-Ping
AU  - Wang AP
AD  - Institute of Clinical Research, Affiliated Nanhua Hospital, University of South 
      China, Hengyang, China.
FAU - Zou, Wei
AU  - Zou W
AD  - Institute of Neuroscience, Medical College, University of South China, Hengyang, 
      China.
AD  - Institute of Clinical Research, Affiliated Nanhua Hospital, University of South 
      China, Hengyang, China.
FAU - You, Yong
AU  - You Y
AD  - Institute of Neuroscience, Medical College, University of South China, Hengyang, 
      China.
AD  - Institute of Clinical Research, the First Affiliated Hospital, University of 
      South China, Hengyang, China.
FAU - Zhang, Ping
AU  - Zhang P
AD  - Institute of Neuroscience, Medical College, University of South China, Hengyang, 
      China.
AD  - Institute of Clinical Research, Affiliated Nanhua Hospital, University of South 
      China, Hengyang, China.
FAU - Tang, Xiao-Qing
AU  - Tang XQ
AD  - Institute of Neuroscience, Medical College, University of South China, Hengyang, 
      China.
AD  - Institute of Clinical Research, the First Affiliated Hospital, University of 
      South China, Hengyang, China.
LA  - eng
PT  - Journal Article
DEP - 20180831
PL  - Switzerland
TA  - Front Psychiatry
JT  - Frontiers in psychiatry
JID - 101545006
PMC - PMC6127318
OTO - NOTNLM
OT  - adiponectin
OT  - autophagy
OT  - chronic restraint stress
OT  - depressive-like behavior
OT  - hydrogen sulfide
OT  - synapse formation
EDAT- 2018/09/21 06:00
MHDA- 2018/09/21 06:01
PMCR- 2018/08/31
CRDT- 2018/09/21 06:00
PHST- 2018/04/15 00:00 [received]
PHST- 2018/08/08 00:00 [accepted]
PHST- 2018/09/21 06:00 [entrez]
PHST- 2018/09/21 06:00 [pubmed]
PHST- 2018/09/21 06:01 [medline]
PHST- 2018/08/31 00:00 [pmc-release]
AID - 10.3389/fpsyt.2018.00399 [doi]
PST - epublish
SO  - Front Psychiatry. 2018 Aug 31;9:399. doi: 10.3389/fpsyt.2018.00399. eCollection 
      2018.