PMID- 30233591
OWN - NLM
STAT- MEDLINE
DCOM- 20190930
LR  - 20190930
IS  - 1664-3224 (Electronic)
IS  - 1664-3224 (Linking)
VI  - 9
DP  - 2018
TI  - Eicosanoid Control Over Antigen Presenting Cells in Asthma.
PG  - 2006
LID - 10.3389/fimmu.2018.02006 [doi]
LID - 2006
AB  - Asthma is a common lung disease affecting 300 million people worldwide. Allergic 
      asthma is recognized as a prototypical Th2 disorder, orchestrated by an aberrant 
      adaptive CD4+ T helper (Th2/Th17) cell immune response against airborne 
      allergens, that leads to eosinophilic inflammation, reversible 
      bronchoconstriction, and mucus overproduction. Other forms of asthma are 
      controlled by an eosinophil-rich innate ILC2 response driven by epithelial 
      damage, whereas in some patients with more neutrophilia, the disease is driven by 
      Th17 cells. Dendritic cells (DCs) and macrophages are crucial regulators of type 
      2 immunity in asthma. Numerous lipid mediators including the eicosanoids 
      prostaglandins and leukotrienes influence key functions of these cells, leading 
      to either pro- or anti-inflammatory effects on disease outcome. In this review, 
      we will discuss how eicosanoids affect the functions of DCs and macrophages in 
      the asthmatic lung and how this leads to aberrant T cell differentiation that 
      causes disease.
FAU - Debeuf, Nincy
AU  - Debeuf N
AD  - Laboratory of Immunoregulation, VIB-UGent Center for Inflammation Research, 
      Ghent, Belgium.
AD  - Department of Internal Medicine, Ghent University, Ghent, Belgium.
FAU - Lambrecht, Bart N
AU  - Lambrecht BN
AD  - Laboratory of Immunoregulation, VIB-UGent Center for Inflammation Research, 
      Ghent, Belgium.
AD  - Department of Internal Medicine, Ghent University, Ghent, Belgium.
AD  - Department of Pulmonary Medicine, Erasmus Medical Center, Rotterdam, Netherlands.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20180904
PL  - Switzerland
TA  - Front Immunol
JT  - Frontiers in immunology
JID - 101560960
RN  - 0 (Cytokines)
RN  - 0 (Eicosanoids)
SB  - IM
MH  - Animals
MH  - Antigen Presentation
MH  - Antigen-Presenting Cells/*immunology
MH  - Asthma/*immunology
MH  - Cell Degranulation
MH  - Cytokines/metabolism
MH  - Eicosanoids/immunology/*metabolism
MH  - Eosinophils/*immunology
MH  - Humans
MH  - Immunity, Innate
MH  - Inflammation/*immunology
MH  - Lymphocyte Activation
MH  - Th17 Cells/*immunology
MH  - Th2 Cells/*immunology
PMC - PMC6131302
OTO - NOTNLM
OT  - asthma
OT  - dendritic cells
OT  - eicosanoids
OT  - leukotrienes
OT  - macrophages
OT  - prostaglandins
EDAT- 2018/09/21 06:00
MHDA- 2019/10/01 06:00
PMCR- 2018/01/01
CRDT- 2018/09/21 06:00
PHST- 2018/07/02 00:00 [received]
PHST- 2018/08/14 00:00 [accepted]
PHST- 2018/09/21 06:00 [entrez]
PHST- 2018/09/21 06:00 [pubmed]
PHST- 2019/10/01 06:00 [medline]
PHST- 2018/01/01 00:00 [pmc-release]
AID - 10.3389/fimmu.2018.02006 [doi]
PST - epublish
SO  - Front Immunol. 2018 Sep 4;9:2006. doi: 10.3389/fimmu.2018.02006. eCollection 
      2018.