PMID- 30234712
OWN - NLM
STAT- MEDLINE
DCOM- 20181220
LR  - 20181220
IS  - 1536-3732 (Electronic)
IS  - 1049-2275 (Print)
IS  - 1049-2275 (Linking)
VI  - 29
IP  - 7
DP  - 2018 Oct
TI  - The Promising Effects of Transplanted Umbilical Cord Mesenchymal Stem Cells on 
      the Treatment in Traumatic Brain Injury.
PG  - 1689-1692
LID - 10.1097/SCS.0000000000005042 [doi]
AB  - Many studies have reported the recovery ability of umbilical cord-derived 
      mesenchymal stem cells (UC-MSCs) for neural diseases. In this study, the authors 
      explored the roles of UC-MSCs to treat the traumatic brain injury. Umbilical 
      cord-derived mesenchymal stem cells were isolated from healthy neonatal rat 
      umbilical cord immediately after delivery. The traumatic brain injury (TBI) model 
      was formed by the classical gravity method. The authors detected the behavior 
      changes and measured the levels of inflammatory factors, such as interleukin-lbeta 
      and tumor necrosis factor-alpha by enzyme linked immunosorbent assay (ELISA) at 1, 2, 
      3, 4 weeks after transplantation between TBI treated and untreated with UC-MSCs. 
      Simultaneously, the expression of glial cell line-derived neurotrophic factor 
      (GDNF) and brain derived neurotrophic factor (BDNF) were measured by 
      real-time-polymerase chain reaction and ELISA.The authors found that the group of 
      transplantation UC-MSCs has a significant improvement than other group treated by 
      phosphate buffered saline. In the behavioral test, the Neurological Severity 
      Scores of UC-MSCs + TBI group were lower than TBI group (P < 0.05), but not 
      obviously higher than control group at 2, 3, and 4week, respectively. The 
      inflammatory factors are significantly reduced comparison with TBI group 
      (P < 0.05), but both GDNF and BDNF were higher than TBI group (P < 0.05). The 
      results indicated that UC-MSCs might play an important role in TBI recovery 
      through inhibiting the release of inflammatory factors and increasing the 
      expression of GDNF and BDNF.
FAU - Qi, Lifeng
AU  - Qi L
AD  - Department of Neurology, School of Medicine, Shandong University, Jinan.
AD  - Department of Neurology, Liaocheng People's Hospital and Liaocheng Clinical 
      School of Taishan Medical University, Liaocheng.
FAU - Xue, Xinhong
AU  - Xue X
AD  - Department of Neurology, Liaocheng People's Hospital and Liaocheng Clinical 
      School of Taishan Medical University, Liaocheng.
FAU - Sun, Jijun
AU  - Sun J
AD  - Department of Neurology, Liaocheng People's Hospital and Liaocheng Clinical 
      School of Taishan Medical University, Liaocheng.
FAU - Wu, Qingjian
AU  - Wu Q
AD  - Department of Emergency, Jining NO. 1 People's Hospital, Jining.
FAU - Wang, Hongru
AU  - Wang H
AD  - Department of Neurology, Liaocheng People's Hospital and Liaocheng Clinical 
      School of Taishan Medical University, Liaocheng.
FAU - Guo, Yan
AU  - Guo Y
AD  - Department of Neurology, Liaocheng People's Hospital and Liaocheng Clinical 
      School of Taishan Medical University, Liaocheng.
FAU - Sun, Baoliang
AU  - Sun B
AD  - Department of Neurology, Key Laboratory of Cerebral Microcirculation in 
      Universities of Shandong, Affiliated Hospital of Taishan Medical University, 
      Taian, Shandong, China.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Craniofac Surg
JT  - The Journal of craniofacial surgery
JID - 9010410
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (GDNF protein, human)
RN  - 0 (Glial Cell Line-Derived Neurotrophic Factor)
RN  - 0 (IL1B protein, rat)
RN  - 0 (Interleukin-1beta)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 7171WSG8A2 (BDNF protein, human)
MH  - Animals
MH  - Behavior, Animal
MH  - Brain Injuries, Traumatic/metabolism/*therapy
MH  - Brain-Derived Neurotrophic Factor/genetics/metabolism
MH  - Glial Cell Line-Derived Neurotrophic Factor/genetics/metabolism
MH  - Interleukin-1beta/metabolism
MH  - Male
MH  - *Mesenchymal Stem Cell Transplantation
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Tumor Necrosis Factor-alpha/metabolism
MH  - Umbilical Cord/*cytology
PMC - PMC6200375
COIS- The authors report no conflicts of interest.
EDAT- 2018/09/21 06:00
MHDA- 2018/12/21 06:00
PMCR- 2018/10/24
CRDT- 2018/09/21 06:00
PHST- 2018/09/21 06:00 [pubmed]
PHST- 2018/12/21 06:00 [medline]
PHST- 2018/09/21 06:00 [entrez]
PHST- 2018/10/24 00:00 [pmc-release]
AID - SCS-18-0310 [pii]
AID - 10.1097/SCS.0000000000005042 [doi]
PST - ppublish
SO  - J Craniofac Surg. 2018 Oct;29(7):1689-1692. doi: 10.1097/SCS.0000000000005042.