PMID- 30234853
OWN - NLM
STAT- MEDLINE
DCOM- 20200911
LR  - 20200911
IS  - 1539-2864 (Electronic)
IS  - 0275-004X (Linking)
VI  - 39
IP  - 12
DP  - 2019 Dec
TI  - FIVE-YEAR FUNCTIONAL OUTCOMES AFTER EPIRETINAL MEMBRANE SURGERY: A Prospective, 
      Controlled Study.
PG  - 2326-2331
LID - 10.1097/IAE.0000000000002323 [doi]
AB  - PURPOSE: To evaluate 5-year functional outcomes involving the inner retina after 
      epiretinal membrane (ERM) surgery. METHODS: The study eye (SE) and fellow eye 
      (FE) of 20 patients undergoing ERM surgery were examined preoperatively and at 3, 
      12, 24, 36, 48, and 60 months postoperatively. Retinal nerve fiber layer and 
      ganglion cell-inner plexiform layer (GC-IPL) thicknesses were analyzed using 
      spectral domain optical coherence tomography. Humphrey visual field mean 
      deviation, pattern SD, and qualitative changes were assessed and compared over 
      time. RESULTS: Mean GC-IPL thickness in SEs was less than that of FEs at all time 
      points with progressive thinning in SEs after ERM surgery. There was significant 
      thinning of the superotemporal GC-IPL in SEs as compared to FEs at 3 months and 
      60 months (P < 0.05). Humphrey visual field mean deviation was greater in SEs as 
      compared to FEs but statistically significant only at 0, 12, and 24 months (P < 
      0.05). Pattern SD increased from baseline in SEs but remained near baseline in 
      FEs. CONCLUSION: Surgical eyes after ERM surgery demonstrated progressive 
      thinning of the GC-IPL and transient worsening trends in Humphrey visual field 
      mean deviation and pattern SD as compared to controls after ERM surgery.
FAU - Jonna, Gowtham
AU  - Jonna G
AD  - Department of Ophthalmology and Visual Sciences, Vanderbilt Eye Institute, 
      Vanderbilt University Medical Center, Nashville, Tennessee.
AD  - Retina Consultants of Austin, Austin, Texas.
FAU - Thompson, Ian A
AU  - Thompson IA
AD  - Department of Ophthalmology and Visual Sciences, Vanderbilt Eye Institute, 
      Vanderbilt University Medical Center, Nashville, Tennessee.
FAU - Mendel, Thomas A
AU  - Mendel TA
AD  - Department of Ophthalmology and Visual Sciences, Vanderbilt Eye Institute, 
      Vanderbilt University Medical Center, Nashville, Tennessee.
FAU - Kim, Stephen J
AU  - Kim SJ
AD  - Department of Ophthalmology and Visual Sciences, Vanderbilt Eye Institute, 
      Vanderbilt University Medical Center, Nashville, Tennessee.
LA  - eng
PT  - Comparative Study
PT  - Controlled Clinical Trial
PT  - Journal Article
PL  - United States
TA  - Retina
JT  - Retina (Philadelphia, Pa.)
JID - 8309919
RN  - 0 (Coloring Agents)
RN  - IX6J1063HV (Indocyanine Green)
SB  - IM
MH  - Aged
MH  - Coloring Agents/administration & dosage
MH  - Epiretinal Membrane/*physiopathology/*surgery
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Indocyanine Green/administration & dosage
MH  - Male
MH  - Middle Aged
MH  - Nerve Fibers/pathology
MH  - Prospective Studies
MH  - Retina/*physiopathology
MH  - Retinal Ganglion Cells/pathology
MH  - Tomography, Optical Coherence
MH  - Treatment Outcome
MH  - Visual Acuity/physiology
MH  - Visual Field Tests
MH  - Visual Fields/physiology
MH  - *Vitrectomy
EDAT- 2018/09/21 06:00
MHDA- 2020/09/12 06:00
CRDT- 2018/09/21 06:00
PHST- 2018/09/21 06:00 [pubmed]
PHST- 2020/09/12 06:00 [medline]
PHST- 2018/09/21 06:00 [entrez]
AID - 10.1097/IAE.0000000000002323 [doi]
PST - ppublish
SO  - Retina. 2019 Dec;39(12):2326-2331. doi: 10.1097/IAE.0000000000002323.