PMID- 30235809
OWN - NLM
STAT- MEDLINE
DCOM- 20181218
LR  - 20230928
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 19
IP  - 9
DP  - 2018 Sep 19
TI  - Ocular Drug Delivery: Role of Degradable Polymeric Nanocarriers for Ophthalmic 
      Application.
LID - 10.3390/ijms19092830 [doi]
LID - 2830
AB  - Ocular drug delivery has been a major challenge for clinical pharmacologists and 
      biomaterial scientists due to intricate and unique anatomical and physiological 
      barriers in the eye. The critical requirement varies from anterior and posterior 
      ocular segments from a drug delivery perspective. Recently, many new drugs with 
      special formulations have been introduced for targeted delivery with modified 
      methods and routes of drug administration to improve drug delivery efficacy. 
      Current developments in nanoformulations of drug carrier systems have become a 
      promising attribute to enhance drug retention/permeation and prolong drug release 
      in ocular tissue. Biodegradable polymers have been explored as the base polymers 
      to prepare nanocarriers for encasing existing drugs to enhance the therapeutic 
      effect with better tissue adherence, prolonged drug action, improved 
      bioavailability, decreased toxicity, and targeted delivery in eye. In this 
      review, we summarized recent studies on sustained ocular drug/gene delivery and 
      emphasized on the nanocarriers made by biodegradable polymers such as liposome, 
      poly lactic-co-glycolic acid (PLGA), chitosan, and gelatin. Moreover, we 
      discussed the bio-distribution of these nanocarriers in the ocular tissue and 
      their therapeutic applications in various ocular diseases.
FAU - Tsai, Cheng-Han
AU  - Tsai CH
AUID- ORCID: 0000-0003-4058-834X
AD  - Graduate Institute of Biomedical Materials & Tissue Engineering, College of 
      Biomedical Engineering, Taipei Medical University, Taipei 11031, Taiwan. 
      m825105004@tmu.edu.tw.
FAU - Wang, Peng-Yuan
AU  - Wang PY
AD  - Center for Human Tissues and Organs Degeneration, Institute of Biomedicine and 
      Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of 
      Sciences, Shenzhen 518055, China. py.wang@siat.ac.cn.
AD  - Department of Chemistry and Biotechnology, Swinburne University of Technology, 
      Hawthorn, VIC 3122, Australia. py.wang@siat.ac.cn.
FAU - Lin, I-Chan
AU  - Lin IC
AD  - Department of Ophthalmology, Shuang Ho Hospital, Taipei Medical University, New 
      Taipei City 23561, Taiwan. ichanlin@gmail.com.
AD  - Department of Ophthalmology, School of Medicine, College of Medicine, Taipei 
      Medical University, Taipei 11031, Taiwan. ichanlin@gmail.com.
FAU - Huang, Hu
AU  - Huang H
AD  - Aier Eye Institute; Aier School of Ophthalmology, Central South University, 
      Changsha 410008, China. huanghu@aierchina.com.
FAU - Liu, Guei-Sheung
AU  - Liu GS
AUID- ORCID: 0000-0003-3379-724X
AD  - Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS 7000, 
      Australia. rickliu0817@gmail.com.
AD  - Ophthalmology, Department of Surgery, University of Melbourne, East Melbourne, 
      VIC 3002, Australia. rickliu0817@gmail.com.
AD  - Department of Ophthalmology, Jinan University, Guangzhou 510632, China. 
      rickliu0817@gmail.com.
FAU - Tseng, Ching-Li
AU  - Tseng CL
AUID- ORCID: 0000-0001-9446-4030
AD  - Graduate Institute of Biomedical Materials & Tissue Engineering, College of 
      Biomedical Engineering, Taipei Medical University, Taipei 11031, Taiwan. 
      chingli@tmu.edu.tw.
AD  - Institute of International PhD Program in Biomedical Engineering, College of 
      Biomedical Engineering, Taipei Medical University, Taipei 11031, Taiwan. 
      chingli@tmu.edu.tw.
AD  - International PhD Program in Cell Therapy and Regenerative Medicine, College of 
      Medicine, Taipei Medical University, Taipei 11031, Taiwan. chingli@tmu.edu.tw.
LA  - eng
GR  - MOST 106-2628-E-038 -001 -MY3/Ministry of Science and Technology, Taiwan/
GR  - MOST 107-2628-E-038 -001 -MY3/Ministry of Science and Technology, Taiwan/
GR  - 1061912/National Health and Medical Research Council/
GR  - n/a/The Ophthalmic Research Institute of Australia/
GR  - n/a/Rebecca L. Cooper Medical Research Foundation/
PT  - Journal Article
PT  - Review
DEP - 20180919
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Biodegradable Plastics)
RN  - 0 (Drug Carriers)
SB  - IM
MH  - *Administration, Ophthalmic
MH  - Animals
MH  - Biodegradable Plastics/chemistry/pharmacokinetics
MH  - Drug Carriers/*chemistry/pharmacokinetics
MH  - Humans
MH  - Injections, Intraocular/methods
MH  - Nanoparticles/*chemistry/metabolism
MH  - *Ocular Absorption
PMC - PMC6164366
OTO - NOTNLM
OT  - anterior
OT  - biodegradable
OT  - drug/gene delivery
OT  - nanoparticles
OT  - ocular
OT  - polymeric
OT  - posterior
COIS- The authors declare no conflicts of interest.
EDAT- 2018/09/22 06:00
MHDA- 2018/12/19 06:00
PMCR- 2018/09/01
CRDT- 2018/09/22 06:00
PHST- 2018/08/02 00:00 [received]
PHST- 2018/09/11 00:00 [revised]
PHST- 2018/09/14 00:00 [accepted]
PHST- 2018/09/22 06:00 [entrez]
PHST- 2018/09/22 06:00 [pubmed]
PHST- 2018/12/19 06:00 [medline]
PHST- 2018/09/01 00:00 [pmc-release]
AID - ijms19092830 [pii]
AID - ijms-19-02830 [pii]
AID - 10.3390/ijms19092830 [doi]
PST - epublish
SO  - Int J Mol Sci. 2018 Sep 19;19(9):2830. doi: 10.3390/ijms19092830.